Objective To explore the diagnostic value of urine retinol binding protein (RBP) ,beta‐N‐acetyl amino glycosidase enzymes(NAG) combined with serum cystatin C (CysC) detection in early kidney damage of type 2 diabetes mellitus (T2DM ) . Methods Totally 58 cases of T2DM complicating in our hospital were selected as the group A ,54 cases of simple T2DM (group B) and 52 individuals undergoing the physical examination(group C) .The urine RBP ,NAG and serum CysC were detected in three groups ,their differences were compared .The positive rates for detecting early diabetic renal damage were compared between the single index detection and combined detection .Results The levels of urine RBP ,NAG and serum CysC level in the group A were significantly higher than those in the group B and C ,the differences were statistically significant (P< 0 .05);the levels of urine RBP ,NAG and serum CysC level in the group B were significantly higher than those in the group C ,the differences were statistical‐ly significant(P<0 .05);The positive rates of single detection of RBP ,NAG and CysC were 87 .93% ,86 .21% and 84 .48% respec‐tively ,the positive rate of 3‐index combined detection was 94 .83% ,which was significantly higher than that of single index detec‐tion ,the difference was statistically significant (P<0 .05) .Conclusion Urine RBP ,NAG and serum CysC are the sensitive indexes in early diabetic renal damage .The 3‐index combined detection has better comprehensive sensitivity and possesses higher clinical ap‐plication value .

Objective To explore the changes of plasma fibrinogen ,plasminogen and D-dimmer before and after thrombolytic therapy in patients with acute myocardial infarction (AMI) ,to provide the evidence for treatment and prognosis AMI .Methods 93 cases of patients with AMI were divided into twe groups ,reperfusion group of 77 cases ,obstract group of 16 cases .At the same pe-riod ,30 cases myocardial infarction of patients with non thrombolytic therapy were selected as control group .The levels of plasma Fib ,Plg and D-dimer in each group were detected at different times .Results The levels of Fib and D-D in AMI patients were higher than those in the control group before thrombolysis therapy (P<0 .05) .Compared with before thrombolysis therapy ,the Fib and Plg levels of AMI patients were decreased significantly after thrombolytic therapy 6 h(P<0 .01) ,and returned to the normal level after 48 h .The D-dimmer level of AMI patients was increased significantly after thrombolytic therapy 6 h(P<0 .01) ,and returned to the normal level after 7 d .After thrombolytic therapy 6 h ,the levels of Fib and Plg of reperfusion group were decreased signifi-cantly(P<0 .05) ,the level of D-dimmer was increased significantly (P<0 .05) .Conclusion The levels of plasma fibrinogen ,plas-minogen and D-dimmer have important reference value for monitor the thrombolytic therapy effect in patients with AMI .