Objective:To observe the clinical effect of acupuncture combined with copper-tube moxibustion on peripheral facial paralysis. Methods:A total of 39 recurrent Bell’s palsy patients were treated with acupuncture plus self-made copper-tube moxibustion, once a day. Ten days made up a course of treatment. The patients were treated for 4 courses of treatment. There was a 3-day interval between two courses. The therapeutic efficacies were statistically analyzed after 4 courses of treatment. Results:Of the 39 cases, 18 cases obtained recovery, 15 cases got improvement and 6 cases failed. The total effective rate was 84.6%. Conclusion:Acupuncture combined with copper-tube moxibustion is effective for recurrent peripheral facial paralysis.

Budd-Chiari Syndrome ; complications ; Humans ; Seizures ; complications

The medical staff's ability to apply medical statistics is deficient at present.In order to bring up eligible students and improve the teaching quality of medical statistics,the author has advanced his thoughts and opinions on teaching contents,teaching ways and examination ways.

Objective: To investigate the inhibitory effects on m yeloperoxidase (MP O) oxidation activity by affinity-purified anti-MPO antibodies from patients w it h microscopic polyangiitis (MPA) and to further investigate the interaction betw een MPO, ceruloplasmin and anti-MPO antibodies. Methods: Human IgG fractions wer e purified from plasma of 11 patients with anti-MPO antibody positive MPA and s e ra of 12 normal controls. Anti-MPO antibodies were further purified from anti- MP O antibody containing IgG fractions using MPO affinity chromatography. The enzym e activity of MPO was measured, in the presence of anti-MPO antibodies and norm a l IgG preparations, using a classical MPO oxidation assay. Interaction between c eruloplasmin, MPO and anti-MPO antibodies was further investigated using ELISA. Results: Anti-MPO antibodies from 7/11 patients with MPA could inhibit the MPO a ctivity as non-competitive inhibitors in a dose-dependent manner. Ceruloplasmi n could competitively inhibit the oxidation activity of MPO in a dose-dependent an d time-dependent manner. Anti-MPO antibodies could inhibit the binding between M PO and ceruloplasmin to a maximum of (75.4?11.6)%. Conclusion: Anti-MPO antibod ies, from the majority of patients with MPA, could inhibit the oxidation activity of MPO and interfere with the binding between MPO and ceruloplasmin.

Hemifacial Spasm ; etiology ; surgery ; Humans ; Trigeminal Neuralgia ; etiology ; surgery

Objective To evaluate the effectiveness of TCM combined with western medicine for advanced gastric cancer.Methods We retrieved literatures of randomized controlled clinical trials related (from January 1991 to June 2012) to the use of TCM combined with western medicine treatment for advanced gastric cancer and made meta-analysis including:the effectiveness,Kamofsky scores and publication bias.Results 44 papers (including 3088 AGC patients) were included.Meta analysis suggested a difference between the treatment group and the control group in effectiveness (Z＝ 6.12,P＜ 0.01),and K score (Z＝ 3.31,P＜0.01).The effectiveness of the reatment group and the control group are 97.8％ and 73.4％ respectively.Conclusion The combined treatment resulted in an improved quality of effectiveness and Kamofsky scores.

Objective To investigate the effects of COMT G472A genetic polymorphism on postoperative analgesia with fentanyl.Methods One hundred and twenty-nine ASA I or Ⅱ patients aged 19-71 yr undergoing operation on lumbar vertebrae under general anesthesia were enrolled in this study.Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the polymorphism of COMT G472A.The patients were assigned into 2 groups according to their genotypes:wild group and mutation group.Pain was assessed using VAS after the patients regained consciousness.When VAS score ＞ 3,the patients were given fentanyl 20μg iv every 5 win until VAS score was decreased to ≤ 3.PCIA was then started.The PCIA solution contained fentanyl 20 μg/kg + flurbiprofenaxetil 150-250 mg or propacetamol 4-6 g in normal saline 75 ml.The patients received a background infusion of 1 ml/h after a loading dose of 3 ml.The PCIA pump was programmed to allow a 0.5 ml bolus with a 15 min lockout interval.The amount of fentan yl infused in 24 h and 48 h was recorded.The amount of flurbiprofen (1 mg=fentanyl 1 μg) or propacetamol (1 g =fentanyl 37.5 μg) was transformed into fentanyl.Results Significantly less fentanyl was consumed in 48 h in mutation group ( n =49) than in wild group ( n =80).Conclusion COMT G472A is a factor contributing to the individual variation in patient' s response to postoperative analgesia with fentanyl.

For more than 40 years primary hepatocytes culture technique has been utilized extensively for assessing effects of drug on metabolizing enzymes (especially cytochromes P450), drug metabolism, drug-drug interactions, and the mechanisms of cytotoxicity and genotoxicity. Human derived primary hepatocytes reserve the metabolism function and enzyme activity of liver. Therefore, this technique has been widely used as a reliable and efficient tool in the drug and xenobiotics evaluation and screen in vitro. This review focuses on primary culture technique of hepatocytes and its application in drug metabolism and toxicology research and evaluation.

Objective To investigate the impact of thymalfasin on cellular immune function and lung function of patients with chronic obstructive pulmonary disease(COPD).Methods 216 patients with COPD in our hospital from March 2011 to August 2014 were randomly selected.According to the digital table,they were divided into the study group (108 cases) and control group (108 cases).The control group was given conventional treatment,while the study group was given thymalfasin on the basis of conventional treatment.Then,the cellular immune function,lung function of each index of the two groups were statistically analyzed.Results The CD3+,CD4+,CD4+/CD8+ of the study group were significantly higher (all P ＜ 0.05),the CD8+ was significantly lower(P ＜ 0.05),the FEV1,FEV1/FVC were significantly higher than the control group (P ＜ 0.05).Conclusion Thymalfasin can effectively improve the cellular immune function and lung function of patients with COPD.

Objective ·To study changes of morphological characteristics of pituitary glands Objective · To study changes of morphological characteristics of pituitary glandsin normal adults by high-resolution magnetic resonance imaging (MRI). Methods · A total of 245 healthy adults were scanned by 3.0T MRI to measurewidths,lengths,heights and volumes of pituitary glands and observe pituitary gland morphology. Results · The average height of pituitary was (5.47±1.33) mm inmales and (6.06±1.32) mm in females; the average volume of pituitary was (614.07±125.52) mm3 in males and (660.00±117.35) mm3 in females. The difference betweenthe genders was statistically significant (P<0.01). The pituitary height was positively related to the pituitary volume (r=0.829,P<0.01). Except the pituitary lengths, there was statistically significance in the pituitary widths, heights and volumes among different age groups (P<0.05), and all of them were negatively correlated with age (P<0.01). Conclusion · The pituitary heights and volumes peak in the 18-29 age group in adults and tend to decline with increased age. In female subjects, however, there is a tendency of pituitary heights and volumes to increaseagain in the 50-59 age group. The average height and volume of female pituitary glands are significantly greater than those of males.