Objective To observe the effect of Auto-CPAP in the treatment of patients with obstructive sleep apnea-hypopnea syndrome,to sum up experience through the treatment.Methods We cured the patients with obstructive sleep apnea-hypopnea syndrome who had been diagnosed by polysomnogram by Auto-CPAP,then observed the improvement in their subjective feelings and objective target aim such as blood pressure and SaO2.Results After treatment by Auto-CPAP.we found their symptom had been improved significantly,for example,the time of sleep apnea decreased or disappeared,the sleep structure had been improved evidently.Conclusion As intelligent CPAP,Auto-CPAP can provide the lowest effective therapy pressure from beginning to end though the inductorium in the face piece,and increase the ease and toleration of the patients,so the curative effects are remarkable.

Short stature is diagnosed according to the person below the normal height of mean -2 standard de-viation or below the third percentile,respectively,of the same race,age,and sex.Diagnosis needs comprehensive assess-ment,including detailed medical history collection,detailed physical examination and appropriate laboratory tests.There are limitations of these factors in diagnosing the reasons of short stature,but the rapid progress on genomics and techno-logy enriched the diagnostic methods.Ongoing research efforts to identify genes influencing growth will provide a better understanding of mechanisms underlying abnormal growth and will eventually lead to novel management approaches.

Eosinophils ; immunology ; Food Hypersensitivity ; etiology ; Gastritis ; etiology ; Humans ; Infant ; Male ; Milk Hypersensitivity ; complications ; immunology ; Milk Proteins ; immunology

Objective To investigate the effects of USP4 on the proliferation of human hypertrophic scar fibroblasts(HSFB).Methods HSFB were cultured in vitro.The fourth generation of HSFB in logarithmic growth phase was selected in the experiment.HSFB were intervened by Vialinin A which was the inhibitor of USP4 for 0,12,24,48 h,then collected cells and the their expression of USP4 and TβRI and Smad7 protein was detected by Western blot.MTT assay was used to detect the effect of Vialinin A on the proliferation of HS fibroblasts and the cells were divided into experimental group and control group(without intervention).Results After treatment with Vialinin A in HSFB,the expression of USP4 and TβRI protein in HSFB decreased gradually,especially in 12 h(P<0.05),and Smad7 protein expression was increased gradually(P<0.05).The proliferative activity of intervened HSFB reduced gradually,the difference between experimental group and control group was statistically significant(P<0.05).Conclusion USP4 might inhibit the proliferation of scar cells and down-regulation of USP4 expression in hyperplastic scar fibroblasts,which can slow proliferative activity of intervened HSFB by regulating TGF-β/Smad signaling pathway.

Objective To explore the curative efficacy,methods and prevention of complications of surgical operations treatment of posted sides chronic subdural hematoma in the adult patients.Methods The clinical data of 11 adult patients suffered from posted sides chronic subdural hematoma were analyzed retrospectively.The patients were all treated by different surgical operations.Results The hematomas about 60mL to 110mL were all cleared away by operation.Postoperative hematoma removal or basic cleared.All patients were cured to discharge.11 patients were followed up for 3 -6 months.According to the activities of daily living (ADL)grading system,all patients were classified as normal.Follow -up examination with CT/MR scans in 11 patients showed 10 cases of normal findings, 1 case with the contralateral limitations mild subdural effusion,by coned cranial indwelling drainage tube turn better. Conclusion Reasonable choice different surgical operations of hematoma is suited to adult patients with posted sides chronic subdural hematoma,providing a satisfactory effect and reduce the complicated syndrome and recurrence rate.

[Summary] Pectus excavatum ( PE ) is a posterior intrusion of the chest wall into the thoracic cavity . Although the physiological and psychological consequences vary , for a large number of patients the lesions are troublesome enough that they need corrective surgery .The minimally invasive repair of pectus excavatum ( Nuss procedure ) has been performed safely , effectively , and extensively .The current situations and progresses associated with the Nuss procedure were reviewed .

Objective To explore variance and resource of intracellular free Ca2+ and extracellular arachidonic acid (AA) in different types of passage cells during the invasion of T. gondii. Methods The variance and resource of extracellular AA and intraceUular free Caz+ of Vero and J774A. 1 cells during the invasion of T. gondii were detected by multi-purpose scintillation counter and laser scanning confocal microscope. Data were analyzed using Chi-square test and t test. Results The intracellular free Ca2+ levels in J774A. 1 and Vero cells were both increased after T. gondii infection. The maximal changes of fluorescence intensity were (1 219.7±58.4)% (P＜0.01) and (356.3±23.6)% (P＜0.05), respectively.The increase of intracellular Ca2+ level in Vero cell was mostly from the release of intracellular Ca2+ store.And the Ca2+ increase in J774A. 1 cell was from both the release of intracellular Ca2+ store and extracellular Ca2+ influx. Extracellular AA levels were significantly increased in both Vero and J774A. 1 cells after T.gondii infection 5.02 and 8. 44 times respectively (t= 3. 124, t = 3. 852, P＜0.01). The AA elevations could be significantly inhibited by phospholipase A2 (PLA2) inhibitor pretreating T. gondii. Conclusions The phospholipase C of phagocytic host cell and PLA2 of T. gondii are activated by T. gondii infection,which results in the increase of intracellular free Ca2+ and extraeellular AA level. Combined actions of Ca2+and AA play a major role in the invasion of T. gondii to host cell. While only PLA2 of T. gondii may be activated in nonphagoeytic host cell.

Objective To evaluate the clinical efficacy of atorvastatin combined with salvianolate in treatment of chronic obstructive pulmonary disease (COPD) complicated with pulmonary arterial hypertension (PH) , and its influence on hypoxia inducible factor-1 alpha (HIF-1α), endothelin-1 (ET-1), adrenomedullin (ADM) in serum.Methods 30 cases of COPD patients with PH were randomly divided into 2 groups, each of 15 cases.The two groups were given conventional treatment, including rest, continuous low flow oxygen, anti infection, relieving cough and phlegm, relaxing tracheal, correcting water and electrolyte balance.Control group was received Atorvastatin Calcium Tablets 20 mg orally, once daily.Observation group was received Atorvastatin Calcium Tablets 20 mg once daily, once daily;salvianolic 200 mg+0.9% sodium chloride solution 250 mL, intravenous drip, once daily.The course of treatment was 10 d.Before and after treatment, 6 min walking distance(6 MWD) and hemodynamic parameters were detected, including pulmonary artery systolic blood pressure (PASP), cardiac output (CO), right ventricular end diastolic pressure (RVEDP) , and HIF-1, ET-1 and ADM level in serum.Results After treatment, 6MWD, PASP, CO, RVEDP of the two groups were significantly improved compared with the same group before treatment.But compared with control group, observation group was improved significantly, the difference was statistically significant (P<0.05).After treatment, HIF-1 alpha, ET-1 of the two groups were significantly lower than the same group before treatment, but ADM were significantly increaser( P <0.05 ) .Compared with control group, HIF-1 alpha, ET-1 of observation group were significantly decreased, while the ADM was significantly increased, the difference was statistically significant (P<0.05).Conclusion Atorvastatin combined with salvia miltiorrhiza polyphenols can significantly reduce the pulmonary artery pressure in patients with COPD and PH, increase exercise tolerance, and its mechanism maybe related to the regulation of the expressions of HIF-1, ET-1 and ADM.

Objective To study the effects of single low-dose intravenous injection of milrinone on plasma cardiac troponin I(cTnI) in rabbits with stunned myocardium.Methods Thirty rabbits with stunned myocardium were included in this study and they were randomly divided into three groups(10 rabbits a group).In sham-operated group(group A),the left anterior descending branch(LAD) of rabbits were not occluded.In ischemia and stunned myocardium group(group B),the LAD of rabbits were occluded for 15min and perfused for 60min.In milrinone group(group C),the LAD of rabbits were occluded for 15min,injected with low-dosage(5ug/kg) of milrinone,and perfused for 60min.Results The content of plasma cTnI in group C was decreased significantly than that in group B(P

OBJECTIVE:To prepare the minoxidil gel and to establish a quality control method for the gel.METHODS:Carbopol934was used as the gel base;the content of minoxidil was determined with UV-spectrogram and the stability test was performed.RESULTS:There was a good linearity of calibration curve of minoxidil in range of2～10?g/ml(r=0.9999).The average recovery was99.8%,and RSD was0.67%(n=4).The gel was stable.CONCLUSION:The gel is reasonable in for?mulation,simple and accurate in quality control,as well as satisfactory in stability.