With the development of the ultrasonic molecular imaging,the invention of a variety of new ultrasound contrast agents can not only improve the sensitivity and specificity of the diagnosis,but also provide new ideas and means for early diagnosis and treatment of hepatocellular carcinoma.The development and perspective of the relative researches were described in this article.

Objective:To investigate the effect of Luteolin on the degranulation function of RBL-2H3 mast cells and its mechanism of action.Methods:DNP-BSA-IgE was used to establish the sensitized cell model in RBL-2H3 cells.Cell viability was exa mined by MTT assay at different concentrations (5,15,25 μmol/L) of Luteolin pretreated RBL-2H3 cells.The effect of Luteolin on β-hexosa minidase(β-hex) and TNF-αwas evaluated by ELISA.The change of Ca2+influx was detected by Flou-4AM calcium ion fluorescent probe.The expression of AKT and P-AKT were detected by Western blot.Results:The sensitized cell model was established successfully .Cell viability had not significantly changes stimulated by different concentrations of Luteolin ,and a significantly inhibition role showed the release of β-hex and TNF-αfrom RBL-2H3 cells.The concentration of intracellular Ca 2+ was significantly decreased.However,the Western blot results showed that the level of Phosphorylation AKT was decreased .Conclusion: Luteolin suppress RBL-2H3 cell degranulation in dose dependence ,which may via impacting the Ca2+influx and the activity of AKT.

Obstructive jaundice is a common disease of hepatobihary surgery,including malignant and benign ones whose treatment and prognosis are obviously different.Malignant obstructive jaundice is one of the dieseases with a worse curative effect,the surgical treatment of this disorder has made much progress in recent years.however there are also some points of disagreement.This acticle reviews the advances of the preoperative preparation,radical excision and palliative drainage in the surgical treatment of malignant obstructive jaundice by reviewing the pertiment literature of China and abroad of recent years.

Objective To evaluate the clinical intubation of Bonfils intubation fiberscope in difficult airway of acromegaly patients.Methods Fifteen acromegaly patients who have one of the following criteria of preoperative airway assessment,Mallampati score ≥3,thyromental distance (≤6 cm),mouth opening(≤3.5 cm).After routine anesthetic induction the patients were intubated with Bonfils intubation fiberscope.Haemodynamic changes were observed and handling of the Bonfils intubation fiberscope was evaluated in terms of the ease of insertion into oropharynx,visualization of epiglottis,advancement into glottis aperture and slide down the tracheal tube.Intubating time and success rate were also recorded.Postoperatively,sore throat or hoarseness were followed up for all patients.Results After intubation systolic pressure and heart rate increased as compared with pre-intubation((P

After the practical experiences with embedded subject service for research in nursing science in Library , The First Affiliated Hospital of Chongqing Medical University was described , such as constructing and recommending resources for nursing staff , helping them to search and read related resources , providing training service of how to write and submit papers , the models of embedded subject service for research in nursing science were summarized , such as laying equal stress on construction and recommendation of resources , systematic service in the embedding processes , and tackling problems by groups in coordination .

Balloon tamponade hemostasis has been applicated for 50 years,and its appropriate usage can obtain exact curative effect with less adverse reactions.In recent years,with the continuous improvement in surgical therapy,balloon tamponade technique in treating various types of bleeding has accumulated many successful experiences.This paper intends to review the advances in balloon compression technology for recent years.

Adult ; Female ; Health Status ; Humans ; Male ; Middle Aged ; Occupational Exposure ; prevention & control ; Physical Examination ; Physicians ; Radiation Injuries ; prevention & control

The visual angle of active participation reference model was not scientific and its contents were not sys-tematic in the past EBM information service. A new EBM information service model was thus established by compa-ring the finding process of evidence and the transforming process ofinformation-knowledge-intelligence with the need of evidence-based decision making in clinicians as a logic starting point in order to provide the theory of what to do andhow to scientifically do for clinical librarians and clinicians, to effectively direct clinical librarians to perform EBM information service, and to help clinicians to scientifically make their decision.

Objective: A retrospective study was performed to compare the efficacy and adverse effects between NIP regimen (navelbine + ifosfamide + cisplatin) and EP regimen (etoposide+cisplatin) as the first-line treatment of advanced combined small-cell lung cancer. Methods: A retrospective study was performed in 167 patients with advanced combined small-cell lung cancer (stages III-IV) eligibly enrolled between January 2006 and December 2010. These patients received NIP regimen (n = 76) or EP regimen (n = 91) as the first-line treatment of advanced combined small-cell lung cancer. All the patients received 2-6 cycles of chemotherapy, and the response was evaluated every two cycles. The primary endpoint was overall survival (OS), and the secondary endpoints were progression-free survival (FPS), objective response rate (ORR) and adverse effects. Results: There was no significant difference in ORR between the NIP group (28.9%, 22/76) and the EP group (40.7%, 37/91) (P = 0.115). The median PFS of the EP group was little longer than that of the NIP group (6.5 vs 5.8 months, P = 0.177). The median survival and one-year survival rates of the NIP group and the EP group were 9.8 months and 35.6% (27/76), and 10.8 months and 49.4% (45/91), respectively; the EP regimen exerted a better survival benefit than the NIP regimen, but it failed to reach a statistical difference (P = 0.883; P = 0.090). The adverse effects of the two regimens could both be well tolerated. The rates of grade I/II leucopenia and alopecia for the NIP regimen were both significantly higher than those for the EP regimen (32.9% vs 11.0%, P <0.001; 35.5% vs 13.2%, P <0.001). Conclusion: The ORR, PFS and OS for NIP regimen are little inferior to those of EP regimen as the first-line treatment of advanced combined small-cell lung cancer, but the differences are not significant. The toxicity of NIP regimen is less tolerable as compared with EP. Thus, the role of NIP regimen in the first-line treatment of advanced combined small-cell lung cancer need to be further comfirmed. Copyright© 2012 by TUMOR.