The serum suppressive activity on PHA-induced lymphocyte transformation of healthy individuals was evaluated in 76 serum samples from 55 patients with systemic lupus erythematousus(SLE).The serum suppressive activity seemed well correlated with the activity of SLE. The highest levels of suppressive rate (55.02+29.62％) and positive rate(88.33％)were found in patients with active disease. Once disease improved, both suppressive rate and positive rate were reduced (22.17?51.28％ and 51.85％ respectively), when the patients entered into stationary stage, the serum suppressive activity were not observed. The correlation between suppressive activity and lymphocyte transformation test, E-rosett inhibition factor, the levels of serum CIC, IgG, IgA, IgM. C3 and ANA titers were analysed. Stepwise discriminant analysis indicated that the serum suppressive activity was more closely related to disease activity than other immunological indexes. The nature of suppressive factor was discussed.

Objective To observe the efficacy of comprehensive strategies in treating diabetic foot.Methods Thirty five cases with diabetic foot were treated by comprehensive strategies,including antiinfection,strict blood sugar control,vasodilatation,improvement of microcirculation,never nutrition,debridement and supportive care,etc.Results Among the 35 patients with diabetic foot,24 were recovered satisfactorily,7 cases were recovered with improvement,2 cases underwent amputation and 2 cases gave up further treatment.Conclusion Diabetic foot can be treated by comprehensive measures satisfactorily,with improved cure rate and low amputation rate.

Recent studies about stem cells show that the formation of portal vein tumor thrombus(PVTT)is closely relative to the metastasis of liver cancer stem cells induced by portal vein microenvironment.Liver cancer stem cells first detach from the primary tumor,extravasate to extracellular matrix,stimulate angiogenesis or intravasate and migrate through the systemic circulation,evade host defense mechanisms,migrate to specific blood vessel sites through chemo-taxis and attach to blood vessel wall,then extravasate through blood vessel and home to specific microenvironment and to form PVTT.

Brachytherapy has become an important treatment for soft tissue sarcoma by its unique radio-biology and radiation physics characteristics, the treatment time is divided in accordance with preoperative brachytherapy, intraoperative brachytherapy, postoperative brachytherapy, brachytherapy alone, which in im-proving the rate of limb preservation and local control rate sarcoma has played an important role. However, the timing of treatment, treatment modalities, the choice of implantation dose is still in dispute.

The paper analyzes the status of hospital websites construction in Jiangau province, which would provide useful evidence for further development. Surfing on the hospital wehaites covering both third and second class hospital in Jiangsu province, it reveals that the websites of third-class hospital are much better than the second-class ones. However, both of them have problems on contents, domain names and interactive parts. The paper suggests that we should constantly explore the methods and ways to solve those existing prob-lems, focus on strengthening informafization construction in hospital and play its advantages.

Background and purpose:Concurrent chemoradiotherapy followed by adjuvant chemotherapy have been administrated to locally advance nasopharyngeal carcinoma according to the NCCN guidelines.This study s pecifically evaluated the efficacy,toxicity and compliance of modified concurrent chemoradiotherapy followed by adjuvant chemotherapy in locally advanced nasopharyngeal carcinoma(NPC).Methods:From Nov.2003 to Apr. 2005,67 patients with stageⅢandⅣlocally advanced nasopharyngeal carcinoma(NPC)were enrolled in this study.A total dosage of radiation,70-74 Gy,was given in 35-37 fractions in 5 fractions per week.Two cycles of chemotherapy, consisting of cisplatin 25 mg/m2?d-1 and 5-fluorouracil 300 mg/m2?d-1 were delivered simultaneously with radiotherapy on the day 1-3 during week 1 and 5.Three cycles of adjuvant chemotherapy,consisting of cisplatin 25 mg/m2?d-1 and fluorouracil 450 mg/m2?d-1,were also given,starting on day 1-3 during week 10,13 and 16.Results:The median follow-up was 20 months(ranged from 11 to 27 months).The 2-year overall survival rate and the 2-year diseasefree survival rate were 91.75%and 81.56%respectively.The 2-year overall survival rate was 96%for stageⅢand 87.65%for stageⅣ(P=0.334).The 2-year disease-free survival rate was 92.16%for stageⅢand 69.35%for stageⅣ respectively(P=0.2358).The compliance rates were 100%for radiotherapy,47 cases(70.1%)for all chemotherapy, 56 cases(83.6%)for concurrent chemotherapy and 48 cases(71.6%)for adjuvant chemotherapy.The main grade Ⅲ/Ⅳacute toxicity events during concurrent chemoradiotherapy were neutropenia in 15 patients(21.4%),vomitting and nausea in 2 patients(3%),mucositis in 56 patients(83.6%),and gradeⅢskin reaction in 10(15%),respectively. The main gradeⅢ/Ⅳacute toxicity events during adjuvant chemotherapy were neutropenia in 13 patients(19.4%), grade 3 anemia in 2 patients(1.5%)respectively.Conclusion:The primary result showed a good compliance,lower incidences of toxicity and improved early outcome of treatments for the patients with stageⅢand stageⅣ(M0)NPC. The ultimate therapeutic ratio will be updated according to longer follow-ups.

Fourteen critical patients were treated by total parenteral nutrition(TPN) or en- teral nutrition(EN) and good results were achieved.Among the1 4patients,1 0 cases were suffered from MSOF.The results suggest thatnutritional support is very im- portant for the critical patients,especially for their rehabilitation and prognosis.The use of TPN is not limited by the gastroin- testinal function.TPN should be sellected preferably when a patient is critical and se- rious.EN should be used when gastroin- testinal function have recovered in order to reduce the translocation of bacteria and en- dotoxin in the gut and decrease gastroin- testinal bleeding.

Henoch-Schonlein purpura(HSP) is one of the most common blood capillary allergic disorder in children, and its pathogenesis has not been well explained. The studies show that the main mechanism of HSP is the abnormality of humoral immunity, and the role of IgA is emphaszed. Meanwhile, many agents such as changes in T cell function,participation of cytokine and mediators of intlammation, suscepti-bility gene and other factors also play an important role in the incidence of HSP. The pathogenesis of HSP can be better understood through extensive analysis of the immunology factors,genetic factors,and so on.

Objective To investigate the effects of titanium nitride(TiN) coating on corrosion resistance of dental Co-Cr alloy in the simulated oral environment. Methods The Co-Cr alloy commonly used was casted with specimen sized of 10 mm× 10 mm×3 mm. Then the specimen was coated with a thickness of 2.5 μm TiN coating on the surface by multi-arc physical vapor deposition. The Tafel polarization curves of the specimen before and after coating titanium nitride in artificial saliva were measured by electrochemical station. Results From the Tafel polarization curves, the specimen after coating TiN showed that both anodic polarization curve and cathodal polarization curve were fiat, natural corrosion potential moved to the positive way, and passivation interval got longer. From the annular anodic polarization curves, the specimen after coating TiN had almost no "delay area". Conclusion TiN coating can improve corrosion resistance of Co-Cr alloy.