Thyroid cancer accounts for the most common endocrine malignancies in women during childbearing age.Many questions remain to be answered regarding the association between thyroid cancer and pregnancy.This review will discuss both the effects of pregnancy on thyroid cancer and vice versa.Recommendations on how to manage thyroid cancer in pregnancy will also be cited from a Chinese academic guideline as listed at the end of this review.

Objective To evaluate the curative effect of reoperation on postoperative recurrent hepatocellular carcinoma (HCC). Method From Jan.1995 to Dec. 1998, 18 recurrent HCC patients underwent 27 sessions of reoperation in our hospital. Result The mean interval between first and second operation among 18 patients was 39?14 months, and for the 9 cases, in which cancer recurred after second surgery, the mean interval between the second and the third operations was 21?4.5 months (P

Along with the globalization of science and technology, the investment on medical research has been increased gradually in recent years, which brings many challenges to the administration of scientific research. The traditional passive conception and model of research administration can no longer meet the needs of modern research development, and therefore changes are urgently needed. The function of research administration in modern medical research needs to be redefined and new characteristics will subsequently arise. The changes are believed helpful in promoting the efficiency of research funding and implementation of the research projects and further facilitating the transformation and application of research achievements.

With the rapid development of life sciences, translational medical sciences have a new significance recent years. Translational medical science aims to eliminate the barriers between clinical, pharmaceutical drug breakthroughs and basic research, to shorten the distance from bench to bed side, and to facilitate rapid patient benefits from medical sciences. Translational medical science concurrently agrees with modern 21st century research trends, as well as emphasizing upon Chinese goals of health and sanitation (hygiene science), preventing and treating disease to preserve and improve health standards and quality of life. Following a long-term self study model of integrating basic with clinic research since 1921, Peking Union Medical College Hospital in collaboration with a variety of basic medical science institutions recently and initiated a pilot project of translational medical science in China.

We in the present research proposed a classification method that applied infomax independent component analysis (ICA) to respectively extract single modality features of structural magnetic resonance imaging (sMRI) and positron emission tomography (PET). And then we combined these two features by using a method of weight combination. We found that the present method was able to improve the accurate diagnosis of Alzheimer's disease (AD) and mild cognitive impairment (MCI). Compared AD to healthy controls (HC): the study achieved a classification accuracy of 93.75%, with a sensitivity of 100% and a specificity of 87.64%. Compared MCI to HC: classification accuracy was 89.35%, with a sensitivity of 81.85% and a specificity of 99.36%. The experimental results showed that the bi-modality method performed better than the individual modality in comparison to classification accuracy.
Alzheimer Disease ; diagnosis ; Case-Control Studies ; Cognitive Dysfunction ; diagnosis ; Humans ; Image Interpretation, Computer-Assisted ; Magnetic Resonance Imaging ; Positron-Emission Tomography ; Sensitivity and Specificity

Clinical Medicine ; Humans ; Infant ; Prospective Studies ; Triazines ; adverse effects ; Urolithiasis ; chemically induced

Animals ; Carcinoma, Pancreatic Ductal ; genetics ; pathology ; Genes, ras ; genetics ; Humans ; Metaplasia ; MicroRNAs ; genetics ; Mutation ; Pancreatic Ducts ; pathology ; Pancreatic Neoplasms ; genetics ; pathology ; Pancreatitis ; genetics ; Signal Transduction

By using ATP-ase histochemical and OKT6 colloidal goldsilver immunohi- stochemical methods, we have studied the location and distribution of Langer- han's cells (LCs) in human esophageal epithelium. The results of our study showed that the dendritic LCs scatter in the basal and middle layers of the esophageal epithelium. The morphology and density of LCs are variable as the age grows and the location changes, more LCs are found in the adult esophageal epithelium than in the foetus, and more LCs are found in the lower segment of esophagus than in the upper segment.

Objective To evaluate the method and result of pollution sources clearance in the reservoir area. Methods Calculated the areas of pollution sources such as pigsties, livestock barns, lavatories, holes for sewage and tombs in the reservoir area of the Yingnahe River, Dalian City after cleared them up in 2002. Collected the soil samples which were not disinfected after clearing up, and the samples disinfected with quicklime or bleaching powder. Evaluation was done according to the GB7959-1987 Standard for the Non-hazardous Treatment of Night Soil. Results The area of pollution source of each livestock barn, pigsty, lavatory, birdhouse, hole for sewage, tomb was 77.4, 74.2, 31.7, 32.1, 36.3 and 158.5 m2 respectively. The qualification rates of the E.coli and the egg of worm counts in the soil samples collected from pollution sources of pigsties disinfected and not disinfected after clearance were 85.94%, 90.31% and 96.88%, 99.38% respectively, the differences were significant. The qualification rates of the E.coli(95.78%)and the egg of worm(99.85%)in the disinfected soil samples collected from the pollution sources in the reservoir area after clearance were close with that of the control collected from the hillside wasteland in the reservoir area. Conclusion Clearance combined with disinfection can make the clearance of pollution sources in the reservoir area meet the request of related standard.

Objective To observe the changes of metallothionein (M T) in the rat flap with ischemia-reperfusion injury. Methods A ri ght lower abdominal island flap was created in Wistar rats . 16 rats were random ly divided into two groups: the control ( n =8) and the ischemia-reperfusion injury group ( n =8). The contents of MT and malondialdehyde (MDA) were assaye d by 109 Cd-hemoglobin saturation and thiobarbituric acid (TBA) methods. Th e activity of myeloperoxidase (MPO) was measured by colorimetry. Results At ischemia 8 h, reperfusion 12 h and 24 h, the level of MDA in rat i schemia-reperfusion injury group increased 41.7 %, 111.4 %, and 135.7 %, the ac tivity of MPO increased 72.1 %, 218.9 % and 296.0 %, the content of MT increased 42.6 %, 52.8 % and 102.3 %, respectively, compared with the control group ( P