Fourteen critical patients were treated by total parenteral nutrition(TPN) or en- teral nutrition(EN) and good results were achieved.Among the1 4patients,1 0 cases were suffered from MSOF.The results suggest thatnutritional support is very im- portant for the critical patients,especially for their rehabilitation and prognosis.The use of TPN is not limited by the gastroin- testinal function.TPN should be sellected preferably when a patient is critical and se- rious.EN should be used when gastroin- testinal function have recovered in order to reduce the translocation of bacteria and en- dotoxin in the gut and decrease gastroin- testinal bleeding.

High-intensity focused ultrasound (HIFU) is a newly-developed noninvasive technique recently. Being a safe, non-radioactive and reproducible therapy, high-intensity focused ultrasound has been extensively used in the clinical treatment for a variety of solid tumors such as uterine adenomyosis. This paper aims to make a comprehensive review about this technique, focusing on the mechanism, clinical indications and contraindications, safety, efficacy and the complications of HIFU for the treatment of uterine adenomyosis.

Kawasaki disease is an acute self-limiting systemic vasculitis syndrome and usually occurs in children.The small and medium arteries of the whole body are mainly invaded, and marked with coronary arteries.Coronary artery dilation and aneurysm formation mainly occur in the early period.Thrombi, intimal hyperplasia, and calcification could be formed during the later period.Consequently, sometimes, it develops intochronicischemic cardiopathy or myocardial infarction.In that, Kawasaki disease has become the leading cause of acquired heart disease for children in developed countries.Presently, the treatment of coronary artery lesions caused by Kawasaki disease includes drug therapy, and interventional and surgical treatment.However, medications usually fail to solve severe coronary conditions, and only interventional and surgical treatment can we choose.Therefore, the development and indications of interventional and surgical treatment of coronary artery lesions caused by Kawasaki disease were reviewed in this article.

Purpose:To study the effect of recombinated human granulocyte colony-stimulating factor (rhG-CSF,filgrastim) on leukopenia induced by chemotherapy.Methods:Ten cases of leukopenia of grade Ⅳ induced by chemotherapy of malignant tumor were treated with rhG-CSF . When WBC2.5?109/L, rhG-CSF was stopped.Results:All patients with leukopenia of grade Ⅳ recovered to normal after treatment with rhG-CSF , the average time of usage was 6.8 days. The infection rate was 60%(6/10). Conclusions:Filgrastim is effective in the treatment of leukopenia of grade Ⅳ after chemotherapy, rhG-CSF decreases infection and facilitates chemotherapy.

Objective To explore the relationship between single nucleotide polymorphisms (rs12953-717) of SMAD7 and susceptibility of non-small cell lung cancer (NSCLC) in Chinese Han population.Methods A single nucleotide polymorphisms (rs12953717) from SMAD7 was detected via Sequenom system in 528 NSCLC cases and 762 healthy controls.Data was statistically analyzed by unconditional Logistic regression method.Results rs12953717 had significant differences between non-small cell lung cancer patients and the controls.Compared with CC/TT (CC combined with TT) genotype,the adjusted odds ratio for the CT genotype was 4.107 (95％ CI:3.206 ～ 5.260,P =0.000 1).Smokers had a 2.004 odds ratio (95 ％ CI =1.583 ～ 2.537,P =0.000 1) of NSCLC compared with the controls.There was a 10.074-fold increased risk of NSCLC among the subjects with CT genotype and smokers.Conclusion The polymorphism of rs12953717 may have relation with risk of NSCLC.Heterozygote (CT) is a susceptibility genotype of NSCLC.Smoking is one of the risk factors of NSCLC.Smoking and CT genotype have synergistic effects on NSCLC susceptibility.

Abdominal Pain ; Cough ; Humans

Objective To explore the methodology of choosing the volume and shape of the mammary implant.Methods The changes of the volume and shape were analyzed in 502 cases of breast augmentation,to find out how to select the volume and shape of the mammary implant.Results The thoracic width H was the most important factor of choosing width of the implant; the SN was the important factor of choosing the height of the anatomic implant; After setting the diameter and height of the implant,a bigger breast could be achieved by increasing the projection of implants.For those very thin females with flat chest, anatomic implants were the better choice. Conclusions Thoracic width,breast volume and other data are the most important factors in choosing the mammary implant.Round and anatomic mammary implants have their specific indications.

50?10~(9)/L. Of the patients, 3 died of liver function exhaustion or disease relapse 1-12 months after transplantation , 2 are still alive with disease for 3-5 months , but others are still alive and disease-free for 3-64 months. Conclusions:PBSCT is a safe therapeutic option that can significantly improve in acute leukemia and malignant solid tumors.

Objective To establish a method for rapid determination of nitrate in air. Methods Nitrate in air was absorbed using Na2CO3-NaHCO3 solution and the content of nitrate in the absorption liquid was determined by ion chromatography. Results The detection limit of NO3- was 0.008 mg/m3 when the sampling volume of air was 100 L. The linear correlation coefficient was 0.999 6. The relative standard deviation of the method was less than 5% and the recovery rates was 92.0%-96.7%. Conclusion The method had good selectivity and was simple and rapid for the determination of nitrate in air.

BACKGROUND: Kainic acid (KA)-induced hippocampal injury in rodents is a good model for studying human neurodegenerative diseases. Although many studies have evidenced that inflammatory molecules and responses participate in and accelerated the process of disease, it is still unclear whether adaptive immune response, especially immune competent cells, such as T and B cells, is involved in the pathogenesis of neurodegenerative diseases.OBJECTIVE: To observe the roles of B and T cell subsets in KA-induced hippocampal neurodegeneration.DESIGN: Randomized controlled animal trial.5ETTING: Department of Otolaryngology and Head, and Department of Neurology, First Hospital, Jilin University; Division of Geriatrics, Department of Neurotec, Huddinge Hospital, Karolinska Institute.MATERrALS: This trial was conducted in the Department of Neurotec, Huddinge Hospital, Karolinska Institute during June to September 2000. Twenty male C57 BL/6 mice (wide-type), and knockout mice CD4(-/-) (n =17), CD8(-/-)(n =19), CD4/CD8(-/-) (n =15) and Igh-6(-/-) (n =14) of C57BL/6 background were involved in this trial. They were aged 5 to 6 weeks,weighing 18 to 20 g. Three age- and body mass-matched C57BL/6 mice received water as controls. Reagent and instruments: KA (Sigma, USA). Bicolor flow cytometer and CellQuest (Becton Dickinson, CA, USA).METHODS: ① Eighty-five anesthetized mice were slowly administrated with 7.69 g/L KA by micropipette which was connected to nose of mouse at the dose of 48 mg/kg. Three control C57BL/6 mice received the same amount of water intranasally. ②Clinical symptoms of mice were monitored. Seizures were graded using a 6-point scale, 0: normal; 6: death.③After 4 to 5 hours of administration of KA, surface immunofluorescence staining of spleen cells was measured with flow cytometer. ④After 7 days of administration of KA, all the mice were anesthetized, and their brains were harvested,then fixed and embedded. For assessment of the severity and extent of hippocampal neurodegeneration by Nissl's staining, the sections were scored by a semiquantitative grading system with a 6-point scale: 0: normal; 6: severe loss of neurons (more than 40% neuron loss in area CA3); ⑤One-factor analysis of variance was used for the comparison of difference among groups and students' t test was used between two groups.MAIN OUTCOME MEASURES: Clinical grade, hippocampal neuropathological changes and the molecular expression of splenic monocytes of mice in each group.RESULTS: Eighty-five mice were involved in the result analysis. ① Clinical grade: All CD4 (-/-) mice displayed severe seizures, and their clinical symptoms were significantly severer than those of wild type mice (P ＜ 0.01). Clinical scores of CD4/CD8 (-/-) mice were significantly lower than those of wide-type mice (P ＜ 0.01). However, the responses of CD8 (-/-) and Igh-6 (-/-) mice did not differ notably from those of the wild-type mice. The clinical grade of control mice was the lowest. ②Hippocampal neuropathological changes: Neurodegeneration was the mildest in CD4/CD8 (-/-) mice and severest in Igh-6 (-/-) mice. ③ Spleen cell subsets changes: the number of splenic CD4+T cells was significantly increased in CD8(-/-) mice and wide-type mice (before and after administration of KA: 8.4%,14.2%;18.2%,31.5%); CD8+T cells were up-regulated in Igh-6(-/-) mice ( before and after administration: 2.1% and 7.4%); B cells rose numerically in CD4(-/-) (Before and after administration: 22.7% and 32.8%).CONCLUSION: Aadaptive immune response is involved in the KA-induced hippocampal neurodegeneration in mice, and B and T cell subsets contribute differently to the pathogenesis.