1.A network pharmacology study of the association between cigarette toxic components and lung cancer genetic susceptibility
Chinese Journal of Biochemical Pharmaceutics 2016;36(9):158-161
Objective To investigate the effects of the main harmful components in cigarette smoke on the expression of lung cancer susceptibility genes by use of the method of network pharmacology, and to explore the correlations of multiple targets and multiple components and diseases.Methods Literatures about the 11 main tobacco toxic ingredients of cigarette smoke were collected from PubMed and the multicomponent-genes-disease network was structured, and then, shared genes which affect the expression of lung cancer susceptibility were screened out.Then use Cytoscape software to construct the multicomponent-shared genes-disease network.Results Network analysis showed that 11 main harmful components in cigarette smoke influnce 106 lung cancer susceptibility genes, 57 lung cancer susceptibility genes of which were affected by at least 2 of the 11 components.Conclusion From the genetic point of view, the relationship of cigarette smoking and lung cancer was elucidated, and the effect of 11 components on the susceptibility genes of other diseases was also explored.This study may provide some statistical references for further detailed research targeting the relationship of cigarette toxic components and lung cancer genetic susceptibility.
5.Diagnosis and differential diagnosis of cervical intraepithelial neoplasias and related disease.
Chinese Journal of Pathology 2007;36(8):563-566
Cervical Intraepithelial Neoplasia
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diagnosis
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metabolism
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pathology
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Cervix Uteri
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metabolism
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pathology
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Cyclin-Dependent Kinase Inhibitor p16
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metabolism
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Diagnosis, Differential
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Female
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Humans
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Ki-67 Antigen
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metabolism
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Membrane Proteins
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metabolism
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Neoplasm Invasiveness
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Uterine Cervical Dysplasia
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diagnosis
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metabolism
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pathology
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Uterine Cervical Neoplasms
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diagnosis
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metabolism
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pathology
6.Paying attention to the correct application of non-steroidal anti-inflammatory drugs in the treatment of ocular surface inflammatory disease
Ming-chang, ZHANG ; Jie, ZHANG
Chinese Journal of Experimental Ophthalmology 2013;32(11):1001-1002
Inflammation is a common ocular surface disease.Glucocorticoid drugs are effective on the ocular surface inflammation,but their long-term and massive application is prone to serious side effects.Nonsteroidal antiinflammatory drugs (NSAIDs) have anti-inflammatory,anti-allergic,analgesic effects.The topical application of NSAIDs for the prevention and treatment of ocular inflammatory disease is much safer than that of glucocorticoid.Therefore,NSAIDs have more and more concerns in the treatment of ocular surface inflammation in recent years.Although NSAID has good anti-inflammatory effectiveness and less adverse effects,it should be correctly administered.During the treatment process of inflammatory ocular surface diseases,the combination of NSAIDs with glucocorticoid drug can strengthen the curative effect and reduce the adverse reactions.
7.Investigate the curative effect on treatment of 40 major aphthous ulcer patients by combined use povidone-iodine,H_2O_ and levamisole liniment
Chinese Journal of Primary Medicine and Pharmacy 2006;0(08):-
Objective To study the curative effect of major aphthous ulcer using povidone-iodine,H_2O_2 asso- ciated with levamisole liniment.Methods The RAU patients were divided into 2 groups randomly.The patients of curative group were instructed to use povidone-iodine,H_2O_2 and levamisole liniment;The control group were in- structed to take metronidazole,antibiotics,compound vitamin B and vitamin C.Then the patients were observed peri- odically.Results The success rate of curative group was 85 % and the control group was 55 %.The difference had statistical significance(P<0.01).Conclusion Treatment of major aphthous ulcer using povidone-iodine,H_2O_2 and levamisole liniment is effective.
9.Updates on molecular markers of prostatic cancer.
Bin CHANG ; Feng LI ; Lu-Jie SONG
Chinese Journal of Pathology 2008;37(5):339-341
10.Etiology and treatment of intra thoracic gastric perforation after esophageal reconstruction with stomach
Bangchang CHENG ; Sheng CHANG ; Jie HUANG
Chinese Journal of Thoracic and Cardiovascular Surgery 2003;0(01):-
Objective To investigate the etiological factors and treatment of thoraco-gastric perforation (TGP) after esophagogastrostomy. Methods Retrospective analysis was carried out in 16 patients with thoraco-gastric perforation after esophagogastrostomy in our department from March 1974 to March 2004. The etiological factor, clinical feature, experiment test and the method of treatment were compared between TGP and patients of thoracic esophageal anastomosis leak (TEAL). Results Thoraco-gastric perforation occurs within 2~5 days postoperatively. Among these 16 cases, in 8, local necrosis of gastric wall was found which was caused by severe contusion and massive ligature. In 5, were penetrative injury of gastric wall caused by suture needle. In 3,unsuitable purse-string suturing of corner of greater or lisser gastric curvature. Hydropneumothorax occurred after thoraco-gastric perforation. Chest fluid was brown and turbid with putrefactive odor. With medium examination, anastomosis was normal, but medium and air bubbles were found outside of the stomach. Perforation were repaired and covered by pedicle tissue-flap in all cases. 15 cases were cured with no sequence. Conclusion TGP after esophagectomy were correlated with technique of surgery. TGP often occurs early after esophagogastrostomy. Transthoracic repairing of TGP should be done as soon as possible. The healing ratio of reparation was about 93.8%.