Objective To investigate the misoprostol and calcium combined treatment of postpartum hemorrhage of cesarean section clinical curative effect.Methods The subjects were cesarean section 68 cases of pregnant women,which were randomly divided into the observation group and the control group,34 cases in each group,the control group at 600 micrograms misoprostol,observed in this group based on the use of calcium(before skin incision slow intravenous push 50％ GS 20 ml + 10％ calcium gluconate 10 ml),observe two groups of intraoperative,postpartum 2 hours and 24 hours postpartum hemorrhage volume.Results In the observation group,intraoperative blood loss[(188.47 + 13.29) vs(385.24±14.16 ml)]was significantly less than that of the control group,2 hours postpartum bleeding volume[(133.56±11.45) vs(219.4±12.73) ml]was significantly less than that of the control group,24 hours postpartum bleeding volume[(171.29±21.91) vs(257.36±33.42) ml]was also significantly less than that of the control group,the difference was statistically significant(t =1.982,1.895,1.714,all P ＜0.05).Conclusion Misoprostol and calcium combined treatment can significantly reduce postpartum hemorrhage of casarean section on maternal and child safety,security,worthy of clinical application.

Colorectal cancer is a common malignant tumor in digestive system ,with an increasing inci-dence rate and case fatality rate all over the world in recent decades .At present,chemotherapy still plays a very important role in the treatment of advanced colorectal cancer .Targeted therapy brings new hope to patients ,and new chemotherapy drugs and targeted drugs have been widely used in clinics .Patient′s life quality has been great-ly improved,survival time has been significantly prolonged ,the combination of chemotherapy and targeted therapy has also become a hot research area in the treatment of metastatic colorectal cancer .XELOX ( capecitabine plus oxaliplatin)as a first-line chemotherapy regimen in treating metastatic colorectal cancer (mCRC)can obtain good therapeutic effect ,the side effects of XELOX are light and well tolerated;Bevacizumab ,as a new type of targeted anti-tumor drugs ,shows a good effect in inhibiting tumor growth and reducing its hematogenous spread risk .Bev-acizumab in combination with XELOX regimen for treating mCRC has been widely investigated and reported .This review gives a brief summary on the efficacy and safety of the combined administration of Bevacizumab and XE -LOX.

BACKGROUND:Acupuncture has been shown to impact cerebral blood flow, relieve cerebral edema, improve microcirculation and reduce neural cel apoptosis in animals with cerebral palsy.
OBJECTIVE:To further verify the effect of acupuncture on neuronal apoptosis in cerebral palsy rats.
METHODS:Forty-five Sprague-Dawley rats were randomly divided into sham group, model group and the acupuncture group, with 15 rats in each group. In the model and acupuncture groups, rat models of cerebral palsy were established by ligating the left common carotid artery. In the sham surgerygroup, the left common carotid artery was not ligated. Rats in the acupuncture group received acupuncture from 2 days after model induction, once a day, for 20 consecutive days. Rats in the sham surgery and model groups were left intact. At 21 days aftersurgery, neurological functions, pathomorphological changes and neuronal apoptosis were observed.
RESULTS AND CONCLUSION:(1) Motor function score was significantly lower in the model group than in the sham surgery group (P< 0.05). Motor function scorewas significantly higher in the acupuncture group than in the model group at 21 days (P< 0.05). (2) Hematoxylin-eosin staining: In the model group, cels were scattered. Inflammatory cel infiltration and cystis degeneration were found. The number of nerve cels was reduced. Degeneration, necrosis, gliosis and karyopyknosis were detected. Cavitation was visible in some cels. Cel bodies became smal. The structure was not distinct or disappeared. In the sham surgery group, the morphology and structure ofnerve cels were normal. In the acupuncture group, the changes in morphology and structure of nerve cels were found between the sham surgery and model groups. (3) The number of apoptotic cels was significantly greater in the model group than in the sham surgery group (P< 0.05). The number of apoptotic nerve cels was significantly higher in the acupuncture group than in the sham surgery group (P< 0.05), but significantly lower than in the model group (P< 0.05). (4) Results confirmed that acupuncture therapy can improve neurological function, reduce nerve cel apoptosis, and play a protective effect on nerve cels of rats with cerebral palsy.

BACKGROUND:Both acupuncture and neural stem cel therapy have good achievements in the treatment of cerebral palsy, but there are few reports about their combined therapy. OBJECTIVE:To observe the therapeutic effect of combined therapy of acupuncture and neural stem cel transplantation on cerebral palsy rats and to explore the relevant mechanism of action. METHODS: Cerebral palsy models were built in newborn rats, and then, the model rats were subjected to acupuncture, neural stem cel transplantation and their combination, respectively. Meanwhile, normal control group and model group were set up. RESULTS AND CONCLUSION:Compared with the other groups, in the combined therapy group, the behavior scores of cerebral palsy rats improved significantly (P < 0.05), the number of nerve cels and Bcl-2 protein expression were increased significantly (P < 0.05), and the number of apoptotic nerve cels and Bax protein expression were decreased significantly (P < 0.05). Additionaly, there were no significant differences in these indicators among the model, acupuncture and neural stem cel transplantation groups. These findings indicate that the combined therapy of acupuncture and neural stem cel therapy can obviously improve learning and memory ability of cerebral palsy rats and reduce neuronal apoptosis, which is probably associated with down-regulation of Bax protein and up-regulation of Bcl-2 protein.

To treat 30 patients with simple adiposis with needling of point Jiaji (Ex-B2, T3-L5), after 2 courses of treatment 12 got a marked curative effect, 15 got a curative effect, 3 got no effect, accounting for 10.0%. The total effective rate was 90.0%.

The present study used optical coherence tomography (OCT) to observe the relationship between inhibitor of monocyte chemoattractant protein-1 (MCP-1) and coronary in-stent restenosis after stenting ,and proved that MCP-1 is a key inflammatory factor causing in-stent restenosis after stenting .

Objective:Use ligustrazin and salvia miltiorrhiza to treat idiopathic pulmonary fibrosis,for the experimental result was perfect in animal modal.Method:These two drugs combined with prednisone in 15 patients as treated group,prednisone in 10 patients as control group.Result:At 1,6 months followed up,the dyspnea and cough improved markedly.Chest radiograph and pulmonary function improved slightly.There were no differences between two groups.After 24 month the combined group 13(73%) stabilized,4(27%) relapse or deterioration,no death.Control group 6(60%) stabilized,3(30%) relapse or deterioration,1(10%) death,Conclusion:Combined group was better then control group.Ligustrazin and salvia miltorrhiza could decrease alveolitis and inhibit the formation of procollagen.It also improve the patient's immunity.

To determine the relationship between Barrett's esophagus (BE) and features of gastroesophageal acid reflux, 24 h esophageal pH monitoring was performed in 90 patients. The patients were divided into 3 groups: 31 subjects with BE, 21 with mild esophagitis and 38 with severe esophagitis. The following parameters were evaluated: the percentage time of pH < 4; the number of reflux episodes over 5 min; the duration of longest episodes and DeMeester score over total period and the auterior three parameters in erect and supine position. All these parameters in BE were significantly different from those with mild esophagitis (P < 0.01) and not significantly different from those with severe esophagitis (P > 0.05). During supine position all the above parameters in BE were significantly different from those with reflux esophagitis (P < 0.05). It is concluded that the quantity of acid reflux is not an important factor in development of BE in gastroesophageal reflux (GER), and the acid reflux in supine position might be important in development of BE in GER.
Barrett Esophagus/etiology ; Barrett Esophagus/*physiopathology ; Esophagitis, Peptic/etiology ; Gastroesophageal Reflux/*complications ; Hydrogen-Ion Concentration ; Supine Position

Background Integrated transepithelial photorefractive keratectomy (TransPRK) is a new kind of surface ablation and has a fast reepithelialization and uncorrective visual acuity (UCVA) recovery as well as slighter postoperative pain,and epipolis laser in situ keratomileusis (Epi-LASIK) has been recognized to be an effective method for myopia.But there have been few studies to evaluate the dynamic change of the corneal biomechanical properties and posterior corneal elevation after TransPRK.Objective This study was to assess and compare the effectiveness and safety between TransPRK and Epi-LASIK for myopia with thin cornea.MethodsThis study was approved by Ethic Committee of Jinan Mingshui Eye Hospital,and written informed consent was obtained from each patient.In this prospective non-randomized controlled study,93 right eyes of 93 myopic patients with the central corneal thickness 460 to 500 μm were included in Jinan Mingshui Eye Hospital from June to December 2013 under the informed consent.The eyes were divided into TransPRK group for 46 eyes and Epi-LASIK group for 47 eyes.UCVA,manifest refraction,haze,corneal biomechanical properties,posterior corneal elevation,Qvalue and corneal high order wavefront aberration were analyzed before and 1 week,1 month,3 months and 6 months after operation,respectively,and the examination results were compared between the two groups.Results There was no statistically significant difference in the eyes of postoperative UCVA and manifest refraction between the TransPRK group and the Epi-LASIK group at various time points (all at P＞0.05).Six months after surgery,the percentage of eyes with UCVA of 1.0 or better was 93.9％,and 90.9％ eyes exhibited the targeted refraction in ± 1.00 D in the TransPRK group.Corneal haze was most obvious 1 month after surgery in both groups,with the incidence of 32.6％ (15/46) in the TransPRK group and 17.4％ (8/47) in the Epi-LASIK group,but no significant difference was found in the eye numbers with haze between the two groups (x2 =2.841,P =0.092).No significant differences were seen in the corneal hysteresis(CH) values and corneal resistance factor(CRF) values between the two groups (CH:Fgroup =0.000,P =0.999;CRF:Fgroup =0.110,P =0.741),however,the postoperative CH values and CRF values were significantly declined in comparison with preoperative ones,with significant differences among various time points (CH:Ftime =103.658,P =0.000;CRF:Ftime =132.008,P =0.000),while there were no remarkable differences between any two time points in postoperation (all at P＞0.05).Posterior corneal surface height shifted rearward 1 week,1 month,3 months and 6 months after surgery,showing remarkable differences in comparison with before surgery in both groups (Ftime =12.868,P =0.001),but no significant differences between the two groups (Fgroup =1.923,P=0.169).No significant differences were found in Q-value between the two groups (Fgroup =0.191,P=0.663).Root mean square (RMS) and spherical aberration values elevated in postoperation compared with preoperation,with significant differences between them(all at P＜0.01),but the comparison between intergroup was insignificant (RMS:Fgroup =0.299,P =0.586;Spherical aberration:Fgroup =1.290,P =0.259).Conclusions TransPRK for myopia with thin cornea is safe and stably effective like Epi-LASIK.TransPRK affects corneal biomecbanical properties early after surgery but the effect gradually lessens over time.The posterior corneal elevation shows a tiny backward displacement,while posterior corneal asphericity has no change.

Neovascular glaucoma ( NVG ) is a series of blinding and intractable eye diseases, which caused by various intraocular or extraocular diseases. The iris and angle neovascularization and vascular membrane fiber contraction may eventually lead to progressive elevation of intraocular pressure and angle closure. Because of complex etiology, the treatment of NVG is intractable and inefficient. Based on the articles published in recent years, we reviewed the progressions of the relevant cytokines and animal models.