Objective To compare the two kinds of general anesthesia and spinal canal anesthesia method for elderly surgical patients of postoperative cognitive dysfunction ( POCD) .Choose the anesthesia methods for clini-cal,reduce POCD provides the basis .Methods 60 patients undergoing surgery anesthesia which were older than to years were divided into general anesthesia group and spinal canal anesthesia group in the two groups ( each group 30 cases),the application of the Mini-getting state ( MMS) test method respectively before anesthesia , patients were matched for 24 hours and 72 hours after the operation test .Results 24 hours,after general anesthesia group of 14 (46.7%),spinal canal anesthesia group of eight (26.7%)patients had significantly lower cognitive function;After 72 hours,there were still three general anesthesia group patients MMS was low ,and cognitive function in spinal canal anesthesia group were back to normal .Compared with the preoperative MMS test basis values ,two groups of patients with postoperative 24 hours MMS values were reduced .General anesthesia group by (23.97 ±3.16) points to (22.37 ± 3.75)points ;Intra-spinal canal anesthesia group fell from (24.73 ±2.98) points to (23.87 ±3.25) points.MMS compared two groups of preoperative and postoperative 72 hours there was no significant difference (P >0.05). Conclusion To prevent cognitive dysfunction in elderly patients ,spinal canal anesthesia should be preferred as elderly surgical patients anesthesia .

0.95)or room air(O2=0.21,respectively.The distributions of AQP1 in the lung tissues were detected by immunohistochemistry and their mRNA expressions were measured by RT-PCR.In addition,the wet-to-dry weight ratio(W/D),the protein content of bronchoalveolar lavage fluid(BALF),lung leak index,histological changes of hyperoxia-induced lung injury were measured respectively.Results:Light microscopic findings in the hyperoxia group including oedema,hemorrhage and extensive inflammatory cells in the lungs were observed.The lung W/D?the protein content in BALF and the lung leak index in hyperoxia group were significantly higher than those in room air group.The expressions of AQP1 mRNA in the lungs were significantly decreased at 3d of hyperoxia-exposure,minimized at 7d and increased from 14d(P

Objective:To investigate the protective effect and the possible mechanism of Rg1 on Cadmium-induced tesicular damage in rat.Methods:30 wistar rats were divided into 3 groups:the control group,the Cd group and the Cd+Rg1 group.The Cd group rats injected intraperitoneally with 0.5 mg/(kg?d) cadmium for 14 days.The rats in the Cd+Rg1 group were pretreated with 75mg/(kg?d) Rg1 by intragastric administration before injected intraperitoneally with 0.5 mg/(kg?d) cadmium.All animals were killed after 14 days,the sperm count,the movable sperm percentage and the abnormal sperm rate in epididymis were analyzed.The content of MT in testis were detected and the apoptosis of testis genital cells were assessed by TdT-mediated dUTP-biotin nick end labeling(TUNEL)technique.Results:14 days after exposed to Cd caused a significant decrease in the sperm count and the movable sperm percentage.On the other hand,the abnormal sperm rate,the content of MT and the apoptosis percent of genital cells in testis were increased significantly.In the Cd+Rg1 group,the sperm count,the movable sperm percentage and the content of MT were higher than that of Cd group,while the abnormal sperm rate and the apoptosis percent of genital cells in testis were significantly lower than that of Cd group.Conclusion:Rg1 have protective effect on on tesicular damage induced by Cd possibly through upregulating the expression of MT in testis.

With the rapid development of China's higher education and the intensified reforms in medical and health services,the problems and contradictions are increasingly prominent in ortho-pedic clinical teaching,especially how to improve medical interns' ability to read images. Picture archiving and communication system (PACS)plays an important role in academic education of medi-cal imaging. Case-based learning (CBL)is a team seminar teaching mode that is guided by cases, based on problems,targeted at students,and dominated by teachers. PACS and CBL were perfectly combined in orthopedic clinical teaching to improve teaching efficiency and the outcome was evaluat-ed through a questionnaire. Results showed that this teaching method inspired students' interests in learning,cultivated the orthopedic clinical way of thinking thus achieved better teaching effects.

Objective To investigate the effect of budesonide inhalation combined with azithromycin in treatment of children with mycoplasma pneumonia and the corresponding clinical nursing pathway.Methods From February 2010 to 2011,100 cases of children patients with mycoplasma pneumonia (all with budesonide inhalation combined with azithromycin) were randomly divided into the experimental group and the control group with 50 patients in each group.The experimental group adopted clinical nursing pathway,while the control group underwent routine care.After one or three-month follow-up,forced vital capacity (FVC),forced vital capacity 1s (FEV1),peak expiratory flow values (PEF) and other pulmonary functional indexes and clinical efficacy were compared between two groups.Results The clinical effective rate of the experimental group was 94％,higher than the control group.FVC,FEV1,PEF changes in the experimental group were better than the control group.Conclusions Budesonide inhalation combined with azithromycin in treatment of mycoplasma pneumonia in children has good effect,coupled with the clinical nursing pathway can effectively improve lung function,reduce the incidence of adverse reactions during treatment,significantly improve the prognosis,should be used widely in clinic.

Osteoporosis is a disease that threatens human health seriously.Orthopedics plays a very important role in the prevention and treatment of osteoporosis.Teachers of orthopedic department should pay more attention to the teaching of osteoporosis and establish specialized courses to make medical students to learn more about osteoporosis in clinical teaching process

CD_(44) adhesion molecule is a cell surface transmembrane glycoprotein.It displays many varinat isoforms generated by alternative splicing of exons, including CD_(44s). and CD_(44v). It has been reported that CD_(44) adhesion molecule is strongly expressed on the surface of leukemic blasts in all acute myeloid leukemia subtypes.It has been found through in vitro study that CD_(44) monoclonal antibodies can inhibit proliferation of all acute myeloid leukemia cell lines and induce terminal differentiate or apoptosis of some cell lines to diverse extent. In this review the relationship between CD_(44v), and leukemia was analysed.

Objective To compare the effectiveness of the forced-air warming system and the conventional warming care practice in preventing hypothermia in patients undergoing major surgeries.Methods A total of 62 patients were enrolled in this study. Patients of both sexes,aged≥18 years,and with an ASA physical status Ⅰ-Ⅲ were included and allocated randomly into intervention group(n=30)or control group(n=32). Patients in the intervention group were provided forced-air warming,either prior to induction or during the surgery procedure depending on core temperature monitoring results. In the control group,patients were warmed with conventional warming care without any intervention. Core temperature was measured by Spot-On sensor and tympanic membrane thermometer,blood pressure,the electrocardiogram,heart rate,pulse oxygen staturation,and partial pressure of end-tidal COwere also monitored continuously in the two groups.Crystalloid,colloid,and allogeneic blood were also recorded by strict protocol. Results Intraoperative hypothermia monitored with tympanic thermometer was observed in 23 patients(71.87%)in the control group,which was significantly higher than that (0) in the intervention group(P=0.00). In addition,the incidence of hypothermia monitored by Spot-On sensor was 81.25%(n=26)in control group and 13.33%(n=4)in intervention group(P=0.00). Conclusion Compared with the conventional warming care,forced-air warming system is more effective in preventing hypothermia during major surgeries.

Objective To observe the effect of nursing intervention on children with hepatitis C receiving Kurorinone treatment.Methods 98 cases of children patients with hepatitis C admired from February 2008 to May 2010 were randomly divided into the intervention group (50 patients)and the control group(48 patients),all patients were treated with kurorinone for 3 months (one course of treatment),besides the intervention group received additional nursing.The liver function and serum HCV-RNA changes were compared between the two groups.Results Recovery of liver function in the intervention group was significantly better,negative rate of HCV-RNA in the intervention group was significantly higher than that of the control group.Conclusions Nursing intervention can improve treatment effect of kurorinone for children with hepatitis C.

OBJECTIVETo investigate the effects of E 4031, a sodium calcium exchanger (NCX) agonist, on the isolated cardiac function and resting Ca2+ level in myocardial cells from rats with chronic heart failure.

METHODSRats chronic heart failure model was established by abdominal aorta coarctation with; Isolated heart perfusion by Langendorff apparatus was used to detect heart function and the effects of E 4031 on haemodynamic indexes; Myocardial cells of rats in the model group were extracted quickly and co-incubated with calcium fluorescent indicator fluo3/AM and the impact of E 4031 on the fluorescence intensity in myocardial cells were evaluated by confocal microscopy.

RESULTSHeart function of rats in the model group detected by Langendorff perfusion was significantly reduced after 12 weeks, E 4031 at 10 micromol/L could improve their left ventricular developed pressure(LVDP) and systolic / diastolic maximum rate (+/- dp/dtmax). Compared with the control and sham operation groups, the resting Ca2+ fluorescence intensity of the myocardial cells of rats in model group was at a higher level and went through a process of transient rise and drop, then stably remaining at a low level after co-incubated with 10 micromol/L E 4031.

CONCLUSIONE 4031 can improve the isolated heart function of rats with chronic heart failure, which may be associated with its enhancing the activity of NCX in the myocardial cell membrane and stabilizing intracellular Ca2+ level.

Animals ; Calcium ; metabolism ; Disease Models, Animal ; Heart ; physiopathology ; Heart Failure ; metabolism ; physiopathology ; In Vitro Techniques ; Male ; Myocardium ; metabolism ; Myocytes, Cardiac ; metabolism ; Piperidines ; pharmacology ; Pyridines ; pharmacology ; Rats ; Rats, Wistar