Objective To investigate the protective effects of ulinastatin (UTI) on ischemiareperfusion injury of donor lungs,and the possible mechanism.Method Forty male SD rats were randomly divided into two groups:group C as control group and group U as UTI group.In group C donor lungs were antegradely flushed with 20 ml of cold (4 C) low potassium dextron (LPD) solution and 5 ml retrogradely.Meanwhile,in group U,UTI (500 000 U/L) was added in LPD solution and the same doses were used.According to the time after initiation of reperfusion,each group was divided into two subgroups:30 min (subgroup A) and 1 h (subgroup B).Arterial blood samples were collected for blood gas analysis.Lung samples were obtained at the end of reperfusion (30 min or 1 h).Microscopic examination of the donor lungs was conducted.Besides,the pulmonary water index (W/D),tissue malondialdehyde (MDA) and superoxide dismutase (SOD) content,and mRNA expression of tumor necrosis factor (TNF-a),intercellular adhesion molecule 1 (ICAM-1) and interleukin 10 (IL-10) were also measured.Results (1) One h after reperfusion,oxygenation index in group U was higher than that in group C (P =0.025) ; (2) The levels of W/D in subgroup A and subgroup B of group U were decreased as compared with group C (P =0.005 and P =0.006) ; (3)The microscopic changes of donor lung tissues in group U were lessen than in group C; (4) In subgroup A of group U,MDA content was decreased (P=0.039),and SOD content was increased (P=0.035),and similar results could be observed in subgroup B of group U (P =0.006 and P =0.030 respectively); (5) As compared with group C,the mRNA expression of TNF-α in group U was decreased at the time of 30 min after reperfusion (P =0.000),but no significant change was found at the time of 1 h (P =0.139).The mRNA expression of ICAM-1 was not decreased evidently at the time of 30 min (P=0.062),but significantly decreased at the time of 1 h (P=0.001).The mRNA expression of IL-10 was increased in subgroups A and B (P =0.004 and P =0.000 respectively).Conclusion This study demonstrated that UTI had protective effects of reducing ischemia-reperfusion injury on the donor lungs after lung transplantation in rat non-heart beating donor models.

OBJECTIVE: To discuss the diagnosis and effective treatment of cystic lymphangiomas located in head and neck in children. METHOD: Fifteen cystic lymphangiomas,diagnosed with pathological evidence, located in head and neck in children were retrospectively analyzed including clinical characteristics, diagnosis, treatment and follow-up data. RESULT: CT and ultrasonography were used to evaluate the size, shape and extent of lymphangiomas in all patients. All patients were treated with surgery. Complete resection was performed in 14 cases, and subtotal resection in one case. Two post-operative complications were found,one was paralyses of mandibular branch of facial nerve, another was Horners syndrome. Tracheotomy operation was done in one case,and the tracheal cannula was taken away before discharged from hospital. Fourteen patients were followed up. There was no recurrence during the follow-up from 6 months to 8 years, while one case who suffered from Horner's syndrome after operation was not cured. CONCLUSION CT and ultrasonography are effective to diagnose cystic lymphangiomas and evaluate the security of clinical treatment. Total or subtotal resection is effective to treat cystic lymphangiomas.
Child, Preschool ; Female ; Head and Neck Neoplasms ; diagnosis ; diagnostic imaging ; surgery ; Humans ; Infant ; Infant, Newborn ; Lymphangioma, Cystic ; diagnosis ; diagnostic imaging ; surgery ; Male ; Retrospective Studies ; Tomography, X-Ray Computed ; Ultrasonography

Objective To explore the clinical application of subxyphoid approach thoracoscopic surgery in thymoma resection. Methods The clinical data of 15 cases of mediastinal tumors receiving subxyphoid approach video-assisted thoracoscopic surgery from June 2015 to May 2017 were analyzed retrospectively.Among these cases,there were 6 male cases and 9 female cases, and the average age was(48.5 ±5.4)years old.There were 6 cases of thymoma with myasthenia gravis,including 5 cases of ocular myasthenia gravis and 1 case of mild systemic myasthenia gravis. Results All the 15 cases of operations were performed successfully without conversion to open surgery.The average operation time was(95 ±15)min, and average bleeding was(50 ±10)ml.The average hospital time was(4.2 ±1.5)days, and average thoracic cavity drainage time was(1.5 ±1.0)days.No postoperative complications occurred.Pathological reports showed that type A thymoma in 8 cases,type AB thymoma in 5 cases,type B1 thymoma in 1 case,and type B2 thymoma in 1 case.The mean follow-up time of all the 15 cases was(6.5 ±2.5)months, and no thymoma recurrence was seen.According to the Monden standard,muscle weakness symptoms disappeared in 5 cases and improved in 1 case in the 6 cases with myasthenia gravis. Conclusion Subxyphoid approach thoracoscopic thymoma resection is safe and feasible.

Objective To summarize the therapeutic experience of thoracoscopic thoracic sympathectomy in treatment of 22 patients with palmar hyperhidrosis.Methods Clinical materials of 22 patients with palmar hyperhidrosis were analyzed retrospectively.Results Totally 22 patients completed surgery successfully.After the operation,the palmar temperature increased with (2.1 ± 1.1)℃,and symptoms relieved or disappeared.The mean operating time was (61.1 ± 18.1) min,and the average hospital stay was (7.4 ± 2.6) d.There were 2 cases of compensatory hyperhidrosis during the perioperative period,and all of them were relieved within 6 months.Conclusion Thoracoscopic thoracic sympathectomy is effective in treatment of patients with palmar hyperhidrosis.

Objective To summarize the therapeutic experience of thoracoscopic thoracic sympathectomy in treatment of 22 patients with palmar hyperhidrosis.Methods Clinical materials of 22 patients with palmar hyperhidrosis were analyzed retrospectively.Results Totally 22 patients completed surgery successfully.After the operation,the palmar temperature increased with (2.1 ± 1.1)℃,and symptoms relieved or disappeared.The mean operating time was (61.1 ± 18.1) min,and the average hospital stay was (7.4 ± 2.6) d.There were 2 cases of compensatory hyperhidrosis during the perioperative period,and all of them were relieved within 6 months.Conclusion Thoracoscopic thoracic sympathectomy is effective in treatment of patients with palmar hyperhidrosis.