AIM: To study the dermal toxicity and absorption of Triptolide Compound Cream.METHODS: 2% azone+1% volatile oil of twig from Camellia.oleifera was used as permeation enhancer to prepare Triptolide Compound Cream.Acute dermal toxicity,irritation a sensitization test on mouse were carried out.And mouse skin in vitro was applied for studying the administration. RESULTS: This compound cream had no acute toxicity,irritation or hypersensitive effects.2% azone+1% volatile oil had more powerful enhancement effects.after 12 h,amont of drug delivery/unit area Q/(?g/cm2) and absorption percentage Q% of triptolide and meloxican in the preparation reached a platea conventration.The results also showed that there was a good linear correlation between the accumulative permeated amount per unit area and the time. CONCLUSION: The study showed that Triptolide Compound Cream has no toxicity on skin,and there is a good dermal absorption.

AIM: To study the dermal toxicity and absorption of Triptolide Compound Cream. METHODS: 2% azone+1% volatile oil of twig from Camellia. oleifera was used as permeation enhancer to prepare Triptolide Compound Cream. Acute dermal toxicity, irritation a sensitization test on mouse were carried out. And mouse skin in vitro was applied for studying the administration. RESULTS: This compound cream had no acute toxicity, irritation or hypersensitive effects. 2% azone+1% volatile oil had more powerful enhancement effects, after 12 h, amont of drug delivery/unit area Q/( μg/cm~2) and absorption percentage Q% of tfiptolide and meloxican in the preparation reached a platea conventration. The results also showed that there was a good linear correlation between the accumulative permeated amount per unit area and the time. CONCLUSION: The study showed that Triptolide Compound Cream has no toxicity on skin, and there is a good dermal absorption.

Objective:To evaluate the performance of rural practitioners of endoscopic cleaning and disinfection participating in the Early Diagnosis and Treatment Program for Upper Gastrointestinal Cancers and to analyze the influencing factors.Methods:The questionnaires for skill assessment were designed based on the skill scheme and clinical practice of the Early Diagnosis and Treatment Program for Upper Gastrointestinal Cancers in rural China, and the App Early diagnosis, Early treatment was used as the examination platform. The practitioners in 539 county hospitals from 25 provinces participating in the program in 2019 were assessed for techniques and skills for endoscopic cleaning and disinfection and the excellence rate was calculated. Multivariate logistic regression model was used to analyze the influencing factors for the examination. Results:A total of 1 671 endoscopic cleaning and disinfection practitioners participated in the assessment with the score of 73.41±16.60. The passing rate was 85.82%, and the excellence rate was 44.94%. Among all questions, the correct rate of "opportunistic screening flow chart" was the highest (98.21%), and that of "the evaluation index for mass screening" was the lowest (57.89%). The multivariate logistic regression analysis showed that the excellence rate was high in practitioners who had a bachelor degree or above ( OR=1.627,95% CI:1.319-2.007, P<0.001), the career for 5 to <15 years (5 to <10 years: OR=1.329,95% CI:1.045-1.689, P=0.020; 10 to <15 years: OR=1.384,95% CI:1.026-1.867, P=0.033), working in eastern and central regions (eastern regions: OR=3.476,95% CI:2.368-5.103, P<0.001;central regions: OR=4.028,95% CI:2.679-6.057, P<0.001) and with full understanding of the screening scheme ( OR=1.547,95% CI:1.246-1.921, P<0.001) . Conclusion:Practitioners on the Early Diagnosis and Treatment Program for Upper Gastrointestinal Cancers in rural China have mastered the basic screening scheme and skills for endoscopic cleaning and disinfection. The education background, duration of the career, area and understanding of screening scheme are influencing factors for the excellence rate of endoscopic cleaning and disinfection.