Objective: To explore influence of exercise training and angiotensin-converting enzyme inhibitor (perindopril) on blood pressure, aortic compliance and cardiovascular tissue structure in spontaneously hypertensive rats (SHR). Methods: A total of 38 SHR aged seven weeks were divided into control group (C group, n=9), exercise group (Exe group, n=9), perindopril group (Per group, n=10) and perindopril + exercise group (Per＋Exe group, n=10). SHRs were observed for eight weeks, and tail-cuff method was used to measure systolic blood pressure（SBP）once a week. When rats were 15 weeks old, regression line（once linear function）was obtained by single regression analyzing the relation between blood pressure and pulse wave velocity（PWV）. The b of this once linear function was used as index of aortic compliance（there was negative relationship between b and aortic compliance）. The left ventricular mass （LVM）/body weight（BW）was used to evaluate ventricular thickening, and aortic weight （AO）/ BW was regard as index of vascular thickening. Results: Compared with C group, SBP of Exe group significantly decreased on 12 weeks old (P<0.01) and 13 weeks old (P<0.05), but decrease of SBP was no significant on 14 weeks old（P＞0.05）. SBP of Per group and Per+ Exe group on eight weeks old immediately decreased to level of seven weeks old (P<0.0001),but there was no significant difference between the two group（P>0.05）. On 15 weeks old, the LVM/BW [(2.19±0.36) mg/g, (2.16±0.32) mg/g ] and AO/BW [(0.20±0.01) mg/g, (0.19±0.01) mg/g] of Per group and Per+ Exe group significantly decreased compared with C group [(2.95±0.58) mg/g, (0.26±0.01) mg/g], P<0.05 all, but there was no significant difference in these indexes between Per group and Per+ Exe group and between C group and Exe group（P＞0.05 both）. The b （index of aortic compliance）were [（C group ：（21.2±1.2）, Exe group：（20.5±1.4）, Per group：（14.8±1.6），Per＋Exe group：（15.0±1.3）] respectively, there was no significant difference between Per group and Per+ Exe group and between C group and Exe group（P＞0.05 both）. Conclusion: The exercise training of eight weeks possesses certain lowering blood pressure tendency, but no significant influence yet for aortic compliance and cardiovascular tissue structure in spontaneously hypertensive rats.

Objective To identify the threshold of percentage of body fat (BF％) associated with diabetes mellitus,hypertension and dyslipidemia in an elderly Chinese population.Methods An individual was considered as a subject if they exhibited any one of the three cardiovascular disease risk factors:diabetes mellitus,hypertension or dyslipidemia.A total of 1 140 subjects were recruited from the Physical Examination Center of Tianjin Hospital,China (male 511,female 629,aged ≥60 years).Questionnaire interview,physical examination,body composition measurement,blood biochemistry measurement,muscle strength measurement and other measurements were performed for each subject.Receiver operating curves (ROC) were created to determine the optimal percentage of body fat cutoff points,with the presence of diabetes mellitus,hypertension or dyslipidemia as outcome variable.Results The percentage of subjects with at least one of the following conditions (diabetes mellitus,hypertension or dyslipidemia) was 62.8％ for men and 73.9％ for women.Increased percentage of body fat was associated with an increased occurrence of diabetes mellitus,hypertension or dyslipidemia in the elderly,particularly among women.The ROC curve shows that the threshold of fat percentage in men and women was 28.2％ and 36.6％,respectively.Conclusion The risks of diabetes,hypertension and dyslipidemia is closely related to elevated body fat mass in the elderly.The percentage of body fat mass is an important indicator of obesity,threshold of BF ％ can provide reference for clinical obesity intervention in elderly patients.It also can provide reference for the treatment and prevention of cardiovascular disease.

Objective To study the effects of.breathing booster training and aerosol inhalation with terbutaline and ambroxol on pulmonary function in postoperative lung cancer patients. Methods A total of 84 patients requiring resection operations for lung cancer were randomly divided into treatment and control groups.In the peri-operative period,breathing booster training and terbutaline and ambroxol aerosol inhalation were given to the treatment group,while only aerosol inhalation was given to the control group.Therapeutic effects were evaluated according to patients pulmonary function and postoperative complications 2 weeks and 1 day before the operation,and again 2 weeks after the operation.Postoperative quality of life (QOL) was evaluated with St.George's respiratory questionnaire (SGRQ) 1 month after the operation. Results There was no statistically significant difference in average pulmonary function between the two groups 2 weeks before the operation.Two weeks after the operation,pulmonary function had decreased in both groups,but it was significantly better in the treatment group than in the control group.The treatment group also had significantly fewer pulmonary complications.The QOL of patients in the treatment group had improved significantly 1 month after the operation. Conclusion Breathing booster training and inhalation of terbutaline and ambroxol aerosol during the peri-operative period can significantly improve pulmonary function,reduce respiratory complications and improve the QOL of patients requiring lung cancer resection operations.This is most important for promoting their early recovery.