OBJECTIVE: To ascertain the main influencing factors of market performance of pharmaceutical industry in China for governmental reference in formulating pharmaceutical industry-related policies. METHODS: The influencing factors of market performance of pharmaceutical industry in China were optimized using multiple linear regression. RESULTS & CONCLUSIONS: The major influencing factors were proved to be the following: the minimum economical scale,current industrial concentration and production expansion capability,which are a little bit different from the classical market performance theory in which the three influencing factors are industrial market concentration,economical scale,and product differentiation.

OBJECTIVE:To provide references for the reformation of private drug wholesale enterprises in Chi?na.METHODS:The private drug wholesale enterprises in China were analyzed in respect to its strength,weakness,opportuni?ties and threats.RESULTS&CONCLUSION:Losing no chances for the reforming of the private drug wholesale enterprises in China is helpful to its development.

OBJECTIVE:To bring the spillover effects of multinational pharmaceutical enterprises'Research&Develop-ment institutions intofull play in China.METHODS:The routes for the exertion of spillover effects and the main restrictive factors of multinational pharmaceutical enterprises were analyzed and some strategies to enhance the spillover effects were put forward.RESULTS&CONCLUSION:The absorbing ability of the domestic pharmaceutical enterprises should be enhanced in China;the flow of the personnel between the multinational enterprises and the domestic pharmaceutical enterprises should be accelerated.We should participate actively in the Research&Development system of multinational pharmaceutical enterprises,reinforce the protection of intellectual property and promote the Research&Development investment of multinational phar-maceutical enterprises in China.

OBJECTIVE:To discuss the outsourcing strategy of pharmaceutical enterprises.METHODS:The feasibility and the necessity of carrying out outsourcing strategy in pharmaceutical enterprises were analyzed based on value chain theory;and the current outsourcing strategies carried out in China pharmaceutical enterprises were evaluated.RESULTS&CON?CLUSION:Outsourcing is a feasible choice for our pharmaceutical enterprises,by which their competitive edge can be im?proved effectively.

OBJECTIVE: To discuss the development of drug data protection in China. METHODS: The specific data protection measures taken by United States (US) and the European Union (EU) were compared and the drawbacks of China drug data protection were analyzed; then some suggestions were put forward. RESULTS & CONCLUSION: The drug data protection in China is still only in its infancy. The Chinese government and drug administration should work out definite drug data protection bylaws by drawing experiences from US and EU.

OBJECTIVE:To discuss the barriers to entry of pharmaceutical industry of our country into international market.METHODS:Directed by the theory of the barriers to entry of the industry organization theory,the barriers to entry into the international pharmaceutical industry was ordered by using the methods of the excess profit,the enterprise numbers,and the proportion of enterprise scale.RESULTS:The barriers to entry into the international chemical pharmaceutical industry and the medical instrument industry are the highest in the sequence of pharmaceutical industry.CONCLUSION:At the time that the industry of our country is reforming,we should regulate and direct the pharmaceutical industry right by using the theory of the industry organization.

OBJECTIVE:To give some information for developing,using and integrating the available resources of R&D efficiently and accelerating the R&D of new drugs.METHODS:Using scale economic and imitational innovational theory,the current situation of R&D of new drugs at home and abroad were dicussed in terms of resource organization and selection of topic.RESULTS&CONCLUSION:Development of scale economics can benefit the R&D of new drugs in China and imita?tional innovation is a practical way in the present stage.

OBJECTIVE:To explore the ways of development of drugstores in China.METHODS:To analysis the current situation of drugstores in China and to study the successful experience of developing drugstores in U.S.A.RESULTS & CONCLUSION:China's drugstores should develop a diversifying economy,implement chain-store operation and shape their own brand products.

OBJECTIVE:To discuss the practice of voluntary principle on the community pharmacy so as to provide some good suggestions for the smooth implementation of the GPP.METHODS:The voluntary principle of GPP was analyzed from several aspects,including the purpose of GPP,the integrated pharmaceutical service level,justice,law and policy and etc.RE_ SULTS:The feasibility of the implementation of voluntary GPP principle in China is expected to be verified,meanwhile,the concerned law and policy should be established in no time and the knowledge of medicine administration should also be publi?cized widely among the public.

OBJECTIVE:To systematically review the efficacy of isotretinoin in the treatment of acne vulgaris,and to provide evidence-based reference for clinical treatment. METHODS:Retrieved from PubMed, Cochrane Library, Wanfang, VIP and CJFD,randomized controlled trials (RCT) about isotretinoin (test group) versus viaminati,macrolides,tetracyclines antibiotics and other drugs (control group) in the treatment of acne vulgaris were collected. Meta-analysis was performed by using Rev Man 5.2 software after data extract and quality evaluation by Cochrane 5.1.0. RESULTS:Totally 28 RCTs were enrolled,involving 3 534 patients. Results of Meta-analysis showed,the total effective rate of isotretinoin was significantly higher than viaminati [RR=1.56, 95%CI(1.27,1.91),P<0.001],macrolides[RR=1.44,95%CI(1.31,1.58),P<0.001] and tetracyclines antibiotics [RR=3.05,95%CI(2.29,4.07),P<0.001];improvement of skin lesions scores was significantly better than control group [MD=0.33,95%CI(0.04, 0.62),P<0.05],the differences were statistically significant. Dry lips,cheilitis,dry skin and nasal mucosa and pruritus were the main adverse reactions,and no serious adverse reactions were showed. CONCLUSIONS:Isotretinoin has better efficacy and safety than viaminati,macrolides and tetracyclines antibiotics.