1.CLINICAL AND LABORATORY RESEARCH ON BIFONAZOL FOR DERMATITS SEBORRHEICA CAPITIS
Jiaxiu CHEN ; Fengxiang YANG ; Chengyan YAUN ;
Journal of Chongqing Medical University 1986;0(03):-
1 8 casts of dermatitis seborrfceica capitis were topically treated with 1% Bifon- azol tincture. All the cases were cured clinically and of the cases turned negative in pathogen cultures. The MIC of Bifonazol to piturosponim ovale were tested in six strains isolated from dandruff.The MIC Bifonazol to Microsporum is 0.25-0.5/ml, slightly superior to Ketokon-azol and Micooazol.The results show that Bifonazol is a hopeful drug for dermatitis seborrheica capi tis and also support the theory that pitytosporem cvale is an opportunistic patogen for dermatitis seborrheica capitis
2.A Multi-center Randomized Double-blind Comparative Clinical Trial of Levocetirizine and Cetirizine for the Treatment of Chronic Idiopathetic Urticaria
Fei HAO ; Hui LI ; Yuangang LU ; Rui YIN ; Jiaxiu CHEN ; Jinjin WU ; Renshan SUN ; Jun DENG
Chinese Journal of Dermatology 1994;0(06):-
Objective To investigate and compare the effect and safety of levocetirizine and cetirizine for the treatment of chronic idiopathetic urticaria (CIU). Methods A multi-center, randomized and double-blind comparative clinical trial was employed. The patients with CIU were divided into levocetirizine group and cetirizine group. Levocetirizine (5mg/day) or cetirizine (10mg/day) were taken once daily for 28 days, and were followed up on the 7th day, 14th day and 28th day after starting treatment. Results One hundred and thirty cases were evaluable for the effect and safety at the end of the study. The effective rates in levocetirizine group and in cetirizine group were 73.44% and 77.27% on the 7th day after treatment, 82.81% and 81.82% on the 14th day, and 89.06% and 81.82% at the end of the therapy respectively. There was no significant difference between the two groups. The drug adverse reaction for levocetirizine group and cetirizine group were 14.06% and 18.18% respectively, which include mouth dryness, dizziness etc. Conclusion Levocetirizine is an effective and safe agent for the treatment of CIU.
3.Lentivirus-mediated knockdown of human E6 AP inhibits gastric cancer cell prolifera-tion and migration
Jiaxiu XIONG ; Zhida CHEN ; Yanan ZHANG ; Xiaomeng JIA ; Yingjie CHEN ; Youhua XIONG ; Lihua DING ; Qinong YE ; Wenzhong LIU ; Bo WEI
Military Medical Sciences 2016;(1):51-54
Objective To detect the effect of E6AP on gastric cancer cell proliferation and migration.Methods The expression of E6AP in different gastric cancer cell lines and normal gastric mucosa epithelial cell lines was detected by Western blotting.Gastric cancer cells BGC-823 stably expressing E6AP short hairpan RNA(shRNA) were obtained by lentiviral vector of E6AP.The effect of E6AP on BGC-823 cell growth and migration was determined by CCK-8 kit, Tran-swell and wound healing assay.Results Gastric cancer cell line BGC-823 in which E6AP was stably knocked down was established.Knockdown of E6AP inhibited the proliferation and migration of BGC-823 cells.Conclusion E6AP plays a key role in gastric cancer proliferation and migration.
4.A multi-parameter resting-state functional magnetic resonance imaging study of brain intrinsic activity in attention deficit hyperactivity disorder children.
Jiaxiu ZHOU ; Yingxue GAO ; Xuan BU ; Hailong LI ; Yan LIANG ; Hong CHEN ; Meihao WANG ; Feifei LIN ; Chuang YANG ; Xiaoqi HUANG
Journal of Biomedical Engineering 2018;35(3):415-420
A great number of studies have demonstrated functional abnormalities in children with attention-deficit/hyperactivity disorder (ADHD), although conflicting results have also been reported. And few studies analyzed homotopic functional connectivity between hemispheres. In this study, resting-state functional magnetic resonance imaging (MRI) data were recorded from 45 medication-naïve ADHD children and 26 healthy controls. The regional homogeneity (ReHo), degree centrality (DC) and voxel-mirrored homotopic connectivity (VMHC) values were compared between the two groups to depict the intrinsic brain activities. We found that ADHD children exhibited significantly lower ReHo and DC values in the right middle frontal gyrus and the two values correlated with each other; moreover, lower VMHC values were found in the bilateral occipital lobes of ADHD children, which was negatively related with anxiety scores of Conners' Parent Rating Scale (CPRS-R) and positively related with completed categories of Wisconsin Card Sorting Test (WCST). Our results might suggest that less spontaneous neuronal activities of the right middle frontal gyrus and the bilateral occipital lobes in ADHD children.