1.COMPARISON OF EXPERIMENTAL MICROSUTURE OF EPINEURIUM AND PERINEURIUM IN RESTORING PERIPHERAL NERVES FUNCTION
Academic Journal of Second Military Medical University 1983;0(S1):-
Under the operating microscope an experiment of epineurium suture by comparison with perineurium suture was performed in sciatic nerves of 20 rabbits. "Strength-duration curve" of tibialis posterior muscle and axons growth rate of distal myelinated fiber were used as the viewing indexes. The end result was showed that there were no obvious differences between both methods in restoring peripheral nerves function. Funicular orientation by direct stimulation was advocated. A new instrument of measuring "Strength-duration curve" was produced.
2.Recurrent lumbar disc herniation after discectomy alone:long-term results
Hua ZHANG ; Jiashun LI ; Xiaojian YE
Orthopedic Journal of China 2006;0(03):-
[Objective]To evaluate the long-term results of recurrent lumbar disc herniation between different kinds of reoperation.[Method]Seventy-four patients of recurrent lumbar disc herniation after discectomy alone were treated surgically from May 2001 to Augest 2005.They were divided into three groups:nonfusion,posterolateral fusion and intervertebral fusion.After a long term follow-up(≥2y),their clinical data were reviewed to compared their improvement rate of lower back pain,JOA score,subside rate of disc height and chang rate of superior intervertebral space angle.[Result]The long-term results revealed that the improvement rates of lower back pain JOA score in the three groups were increased in sequence.The differences in subside rate of disc height and change rate of superior intervertebral space angle between discectomy and posterolateral fusion groups were insignificant,but much higher than those of posterior lumbar interbody fusion group.[Conclusion]Posterior lumbar interbody fusion is effective in increasing the improvement rates of lower back pain JOA score and maintaining the disc height and the superior intervertebral space angle.
3.Lumbar Spinal Stenosis Associated with Disc Protrusion
Lianshun JIA ; Jiashun LI ; Hongkui LIU
Academic Journal of Second Military Medical University 1985;0(05):-
Sixty-eight patients with a surgically proven lumbar stenosis associated with disc protrusion were studied retrospectively. According to the essential clinical feature the patients were divided into three groups: Group 1, intermittent claudication (n=21), Group 2, low back pain associated with unilateral aciatic pain (n=42), and Group 3, intermittent claudication coexisting with bilateral or unilateral leg pain (n=5). The final diagnosis prior to operation was difficult to make. Surgical decompression of the spinal canal required removal of the portion of hypertrophied superior articular faced and prolapsed disc. Fifty-eight patients were followed up from 6 months to 6 years and 3 months. In 41 patients preoperative neurogenic symptoms completely disappeared, 14 still an occasinal bachache, existed and 3 moderate symptoms persisted postoperatively.
4.Neurologic evaluation and curative effect facts of cervical spondylotic myelopathy anterior decompression and fusion
Yuhua HU ; Changfeng WANG ; Jiashun LI
Orthopedic Journal of China 2006;0(13):-
[Objective]To study the neurologic criterion and curative effect facts of cervical spondylotic myelopathy.[Method]A prospective study was carried out and 21 cases of cervical spondylotic myelopathy were involved in this investigation to be classified by Nurick grade,JOA score and 40 cent classification.The possibility curative effect facts were analysed.[Result]The patients were followed up for average 11 months.Spinal cord function score were improved by 2~3 grades according to Nurick grade;1~6 cent to JOA score and 7~12 cent to 40 cent postoperation.Height of vertebral,cervical lordosis,centrum posterior decompression being unenough,excess height of centrum were curative effect facts of cervical spondylotic myelopathy.[Conclusion]Nurick classify allow even more contrast,but unsuit to some Cervical spondylotic myelopathy,JOA is simple and convenit,efficienf and across-the-aboard;40 cent assess measure is impersonality but cockamamie.Height of vertebral and centrum posterior decompression being unenough are most important facts about surgery.
5.Molecular mechanism of activator protein-1 and macrophage inflammatory protein-1? in adjuvant arthritis rats and the effects of sodium arsenite
Long LI ; Jiashun ZENG ; Yingqiang CHEN
Chinese Journal of Rheumatology 2003;0(11):-
Objective To study the molecular mechanism of activator protein (AP)-1 and macrophage inflammatory protein (MIP)-1? in adjuvant arthritis and the effects of sodium arsenite (SA) on AP-1 and MIP-1. Methods Forty Wistar female rats were randomly divided into 4 groups: normal control (NC), model (M), low concentration sodium arsenite (SA1) and high concentration sodium arsenite group (SA2). The SA1 group and the SA2 group were treated with sodium arsenite (0.5 mg?kg-1?d-1 and 1.0 mg?kg-1?d-1) through abdominal cavity injection for 20 days, the normal control group and the model group were treated with saline (0.2 ml/d). The levels of C reactive protein (CRP) in every group were determined by biochemistry, the C-fos and MIP-1? expression of synovium in 4 groups were determined by immunohistochemistry. Results The levels of CRP in the M group were increased more than NC group (P
6.Arterial angiographic embolization in treatment of severe pelvic fractures
Junming TAN ; Jiashun LI ; Lianshun JIA ;
Academic Journal of Second Military Medical University 1981;0(03):-
Pelvic fractures are high energy injuries involving severe trauma and potential intra pelvic bleeding. Immediate control of hemorrhage, fixation of pelvic fractures and inter department cooperation are important for their treatment. Transcatheter angiographic embolization can be used to identify bleeding sites, control hemorrhage and improve mortality and complications, and it has been proved to be a valuable technique in the diagnosis and treatment of pelvic vascular injuries. Still there is a considerable controversy on the fracture patterns, the sequence and the timing of emergency angiography and possible embolization in these patients. In this paper, we reviewed the role of angiographic embolization and we thought more attention should be paid on angiographic embolization in the control of hemorrhage.
7.Progress in surgery intervention for craniocervical unstability
Guohua XU ; Jiashun LI ; Lianshun JIA ;
Academic Journal of Second Military Medical University 1982;0(01):-
Craniocervical unstability may cause severe motor and respiratory compromise due to recurrent upper spinal cord and/or brain stem impingement.In recent years,by improving internal fixation materials and surgical techniques,the methods of surgical treatment of craniocervical unstability has made great progress.With the appearance of these new surgery and internal fixation methods,the successful rate and safety of the operation obviously increased and the complications was reduced greatly.We reviewed the surgery methods for craniocervical unstability in this article.
8.Protective effect of ciliary neurotrophic factor on spinal neurons
Bin XU ; Hong WU ; Lianshun JIA ; Jiashun LI
Journal of Medical Postgraduates 2001;14(2):132-134
Objectives:To study the enzymatic changes and protective effects of ciliary neurotrophic factor (CNTF) on neurons in spinal cord injury (SCI).Methods:SD rats were subjected to incomplete SCI with modified Allen methods.Activities of acetylcholinesterase (AChE) and acid phosphatase (ACP) in spinal cord were quantitatively measured preoperatively,and 3,7,14 days after SCI.Results:AChE activity decreased gradually after injury.ACP activity increased 3 days after injury,and reached peak on the 7th day,then recovered gradually.The rats treated with CNTF showed relatively smooth change of the 2 kinds of enzymes.Conclusions:CNTF plays a role in protecting the spinal cord neurons against injury.
9.Gene expression pattern of cervical intervertebral disc degeneration in rats
Yongjun WANG ; Qi SHI ; Jiashun LI ; Lianshun JIA ;
Academic Journal of Second Military Medical University 1999;0(12):-
Objective: To investigate the gene expresssion changes in normal and degeneration cervical intervertebral disc in rats, providing information for clinical diagnosis and treatment of cervical intervertebral disease.Methods: The models of cervical intervertebral disc degeneration in rats caused by imbalance between the dynamic and static forces was established.cDNA microarray chips containing 512 cDNAs were used to investigate the gene expression pattern in cervical intervertebral disc of rat.The results were scanned and analyzed by computer image analysis,and then subjected to standardization,ratio and clustering analysis.Results: Eighteen genes expressed in cervical intervertebral disc were screened out,comprising 11 up regulated and 7 down regulated ones,respectively.This genes expression in cervical spondylosis was similar to other reports.Conclusion: Signal transduction pathways plays an important role in the process of cervical intervertebral disc degeneration.Investigation on the gene expression pattern is helpful for studying degeneration of cervical intervertebral disc pathogenesis.
10.Experimental study of interbody fusion using CFR/PEEK
Zhicai SHI ; Jiashun LI ; Lianshun JIA ; Wen YUAN ; Tiesheng HOU ; Ming LI ; Xiaodong ZHU
Academic Journal of Second Military Medical University 2001;22(4):340-342
Objective: To study the biocompatibility of CFR/PEEK composite in bone tissue after implanted in lumbar intervertebral space and to evaluate its role in the interbody fusion compared to the allograft bone. Methods: Thirteen beagles were chosen among which 7 were implanted with the disk-like CFR/PEEK composite in the lumbar intervertebral space and the other 6 were implanted with allograft bone. X-ray, QCT and histological examination were employed at 6, 12 and 24 months postoperatively. Results: The X-ray results of fusion segment were in conformity with the QCT's as well as that of histological results. All animals obtained a complete fusion at 24 months. Histological examination revealed that the anterior soft tissue to the implant exhibited a nonspecific foreign body reaction with connective tissue embed the biomaterials. Carbon fragment were seen in the surrounding tissue and some of the debric were phagocytosed by foreign body giant cell. Histological examination of bone and material revealed that new bone grew along the hole of CFR/PEEK implant. Conclusion: CFR/PEEK has an excellent biocompatibility to bone tissue.