ObjectiveTo observe the clinical efficacy of vesiculation moxibustion plus Levofloxacin in treating chronic bronchitis.MethodEighty-three eligible patients with chronic bronchitis were randomized into an observation group of 43 cases and a control group of 40 cases. The control group was intervened by orally taking Levofloxacin,while the observation group was additionally intervened by vesiculation moxibustion. The clinical efficacy in the two groups and the safety of vesiculation moxibustion were evaluated.ResultThere was a significant difference in comparing the total effective rate between the two groups (P<0.05), and the observation group was superior to the control group; vesiculation didn’t cause fever, obvious swelling, or big blisters, etc.ConclusionVesiculation moxibustion plus Levofloxacin can produce a satisfactory clinical efficacy in treating chronic bronchitis, and it’s safe and reliable without obvious adverse reactions and worth application in clinic.