Objective To investigate the allergen of asthma in children in order to instruct family management and improve the quality of life of children with asthma. Methods Skin prick was used to detect the allergen of asthma in children. Family management program was designed for patients with posi-tive results and implemented under supervision. Controlled study of patients adopting family management program and patients without this program was performed for 1 year. Results 78 cases of 104 children (75.0%) with asthma were positive for allergen. Among 78 cases, 58 cases were positive for der-matophagoides culinae, and 49 cases were positive for dermatophagoides pteronyssinus, which were two main allergens. The one- year follow- up research results showed: 14 cases once suffered emergency treat-ment, 6 needed hospitalization, 12 absent from classes and the average economic cost reached 1840.5 yuan per patient per year among 52 patients who received family management program.While in 26 patients who did not adopt family management program, 15 cases once suffered emergency treatment, 10 needed hospi-talization, 14 absent from classes and the average economic cost reached 3267.3 yuan per patient per year. The difference was significant. Conclusions Family management guide can improve the quality of life in asthma children positive for allergen.