Objective To investigate the function and effect of early rehabilitation for patients with low position paraplegia and refractory pressure sore. Methods 15 patients with low position paraplegia and refractory pressure sores were given modified vacuum-assisted closure treatment, at the same time, rehabilitation and intervention for functional training of limbs, bladder, intestinal was carried out to enhance capacity of psychosocial adjustment in patients. Results 15 cases of paraplegia patients with refractory low pressure sores were all cured, no pressure sores relapsed at follow-up visit six months later. Conclusions Early intervention can improve the rehabilitation of self-care capabilities, improve patients' individual skin-care ability, speed up the healing of pressure sores in patients with paraplegia, so as to reduce pressure sore recurrence.