Objective To observe the therapeutic effect of Dan-Shen Injection in the treatment of acute pancreatitis. Methods Forty-two cases of acute pancreatitis were classified into 2 groups randomly. The control group was given routine treatment. The therapeutic group was given with routine treatment combinat-ing with Dan-Shen Injection. Results The number of normal WBC cases within 7 days was more in the therapeutic group than that in the control group (P < 0. 05). The recover time of amylases in blood was shor-ter in the therapeutic group than that in the control group (P < 0. 05). The incidence rate of complication, the operative rate and the mortality in the therapeutic group were lower than that in the control group (P <0.05). Conclusion In the treatment of acute pancreatitis, Dan-Shen Injection can enhance the therapeutic efficacy, shorten the course of treatment and reduce the incidence rate of complication and the mortality.

Objective To observe the curative effects of azithromycin combination with clindamycin on the treatment of children with mycoplasmal pneumonia. Methods 146 children were divided into control group and observation group randomly.Azithromycin was used to treat 69 children in the control group while azithromycin combination with clindamycin was used to treat 77 children in the observation group.The curative effects and adverse effects were observed. Results The total effective rate of control group was 81.2%,which was significantly lower than that in observation group(94.8%),(x2=6.59,P＜0.05). Conclusion Azithromycin combination with clindamycin was an effective and safety method to treat the children with mycoplasmal pneumonia.

Objective To evaluate the effects of unilateral extralevator abdominal-perineal excision (ELAPE) surgery and the ELAPE surgery on the pelvic floor detected by finite element analysis. Methods Three kinds of finite element mod?el were developed:the intact model, ELAPE model and the unilateral ELAPE model. The maximal stress and stress distribu?tions of each model under the same pressure were analyzed and compared. Results In the unilateral ELAPE model, non-le?vator ani tissue’s maximal stress on the levator ani reserved side was lower than that in ELAPE model, and was similar to that in the intact model. Its maximal stress on the excised side was lower than that in ELAPE model, and which was higher than that of intact model. Its maximal stress on the reserved side was lower than that of on the excised side. Conclusion Compared to the ELAPE surgery, the unilateral ELAPE surgery is able to reduce the stress of non-levator ani tissue on both sides, especially on the levator ani reserved side.

AIM: To investigate the influence of television programs on children's mental growth so as to evaluate advantages and disadvantages on coordinative development of TV programs and child education.METHODS: A survey about the quality and audience rating of children's TV programs was carried out at the Developmental Psychology Institute of Beijing Normal University.RESULTS: The television programs have three main functions for children: education function (or learning function, orientation function), information function and entertainment function. Main purposes and effect for watching TV by children are: ①The major two are entertaining and getting information to enrich their knowledge, but other purposes like training thinking ability and learning skills still exist. ② Children TV programs can promote learning knowledge, skill, and academic study; develop intelligence and personality. Problems mentioned above have the age differences. However, the negative effect on child should not be neglected: ① A lot of unhealthy contents block children's healthy development. ②Watching TV for hours wastes a lot of valuable time that can be used for other important things like reading. This time-killing habit may harm children's profound thoughts and thinking ability.CONCLUSION: We should present new philosophy on children's TV programs producing. The producer should know well about children's needs and respect their requirements, including all kinds of rights and ideas, linking the entertainment function of these programs more closely with their education function and taking advantage of successful business models oversea, and inspiring organizations to produce more suitable programs.

BACKGROUND: Being a traditional Chinese herb, huangqi (astragalus membranaceus) resists free radical, enhances immunity, promotes microcirculation and protects vascular endothelial cell and nervous system; of which, the protection of huangqi (astragalus membranaceus) on nervous vessel is related to its regulation on local cerebral cortical blood flow rate. OBJECTIVE: To observe the effects of huangqi (astragalus membranaceus) on local cerebral cortical blood flow rate after traumatic injury. DESIGN: Randomized paired experiment.SETTING: Neurological Surgical Institute of Lanzhou Military Area Command of Chinese PLA.MATERIALS: The experiment was performed in Traumatic Experimental Room of Neurological Surgical Institute of Lanzhou Military Area Command of Chinese PLA from February to May 2000, in which, 75 healthy male SD rats were employed and randomized into the control (5 rats), saline control (35 rats) and experimental group (35 rats). The latter two groups were subdivided into 7 time spots of 1, 3, 6, 8, 12, 24 and 48 hours after traumatic injury, 5 rats were involved in each spot.METHODS: In normal control, the model was not prepared and in the other two groups, the modified Feeney's method was used to establish craniocerebral traumatic model. In experimental group, right after injury, huangqi injection (5 g/kg) was applied abdominally and in saline control, physiological saline 0.5 mL was injected abdominally. MAIN OUTCOME MEASURES: It was to determine the blood flow rates in local cerebral cortex at corresponding time spots after traumatic injury. Fenestration was done in normal control for direct determination. RESULTS: By supplemented, 75 rats entered result analysis. Blood flow rates in local cerebral cortex: the rate in saline control 1 hour after trauma was lower than the control [(6.90±0.68), (7.94±0.65), P < 0.05], it was de creased to the minimum in 24 hours and began increasing in 48 hours [(5.86±0.61), (6.15±0.60)]; the rate in experimental group at every time spot was higher than saline control (P < 0.05). CONCLUSION: Huangqi (astragalus membranaceus) increases remark ably blood flow rate in local cerebral cortex, which is associated with its neurovascular protection.

BACKGROUND: Most of previous researches on the emotion regulation ability only took children as objects.There were very few studies to investigate the adolescents' emotion regulation ability.There are fewer researches tried to study over-province large sampling to get general situation of Chinese adolescents' emotion regulation ability. Very few studies have taken emotion regulation as independent factor and explored its developmental rules OBJECTIVE:To analyze the characters of grade and gender in emotion regulation ability of Chinese adolescents DESIGN:Cross-sectional sampling survey questionnaire with adolescents as subjects SETTING:Institute of Developmental Psychology of Beijing Normal University.PARTICIPANTS:Totally 11 855 students from junior and senior high schools in Beijing,Henan,Chongqing,Zhejiang and Xinjiang, 13 high schools are included.METHODS:The present study uses "the adolescents' emotion regulaPsychology Institute, Beijing Normal University) as measuring tool to grouply test with the class as a unit. The tests in the 5 districts were completed within 2 weeks. The questionnaire is a 5-point scale.The level of emotion regulation is the mean score of the 14 items. And the higher points means higher level of emotion regulation.in emotion regulation between different grades of adolescent.RESULTS:Main effect of gender is not significant (F(1.11843)=0.040,P=0.842),while main effect of grads is significant (F(5.11843)=101.437,P=0.000),and interaction effect between gender and grades is significant (F(5.11843)=3.812,P=0.002).CONCLUSION:The emotion regulation ability of adolescents increased with the increasing grade but being stable after grade 11;the girls' emotion regulation ability exceeds the boys' gradually in grade 11,and there is no difference in the emotion regulation ability between boys and girls in grade 12.

Objective We established a model of human breast cancer in nude mice, to discuss the feature of pathology and biology of breast cancer,and give help to establish tools of pathogen research. Methods Human breast cancer cells MCF-7 were subcutaneously injected into the right armpit of nude mice to establish human breast cancer models.The mice were divided into composite group, estrogen group, leptin group and the blank group (30 in each). In the composite group,estrogen and leptin were injected into peripheral region of the tumor daily.In the estrogen group,estrogen was injected.In the leptin group, leptin was injected.In the blank group, physiological saline was injected.Tumor growth was observed, and the volume of the tumor was recorded.The tumor tissues obtained from the mice were pathologically examined. Results (1)The tumor-taking rate of leptin group and the blank group were 46.7% (14/30)and33.3% (10/30) ,and the mode is failure.In composite group and estrogen group they were 96.7% (29/30) and 70% (28/30).There was not significant difference between them ( P < 0.05).(2) The differences of average diameter and volume were statistically significant between the composite group and the estrogen group (P < 0.05).(3) Pathology diagnosis was invasive ductal carcinoma. Conclusions (1) Establishing human breast cancer model in nude mice need the stimulation of estrogen. The tumor-taking rate of nude mice has no relationship with leptin.(2) In the study in vivo, leptin as same as estrogen has stimulating effect on MCF-7 cells proliferation.(3) The transplanted cancer cell partly have the pathology and biology features of the human breast cancer cells and give help to establish tools of pathogen research.

Objective To investigate the expression of extracellular signal-regulated kinase 1/2(ERK1/2) and transforming growth factor ?1(TGF-?1) in heart of spontaneous hypertensive rat.Methods The expression of ERK1/2 and TGF-?1 was determined by immunohistochemistry and Western blot.Results In arteriole of the heart of 8,16,and 20 week-old SHR,the rate of positive ERK1/2 staining at the endothelium(15.38%,76.97% and 72.72%,respectively) and at the vascular smooth muscle cell(VSMC) of 16 and 20 week-old SHR(5.49% and 6.83%,respectively)were significantly higher than that of control group(P

Objective Study the value of clinical application of BaiJi and absorbable Gelatin in embolizing uterine myoma together with its effecty, side effect and complication.Methods 21 women with uterine myoma undergoing selective uterine arterial embolization by Seldinger's technique were studied. After retrograde transfemoral introduction of a 5 french catheter, the uterine arteries were successively catheterized. Bai Ji and absorbable Gelatin sponge particles were injected through free flow until devasculariztion. Results Uterine myoma's blood supply came from bilaterial uterine arteries demonstrated by angiography. All the supplying artering images disappeared after the embolization. 3～6 months follow up study showed: a marked reduction in the size of myomata by 38%～90%. Clinical symptoms were improved. There was one failure cas and then underwent uterotomy due to infection. Conclusions The short term effect of using Bai Ji and absorbable Gelatin for embolizing uterine myoma is clinically significant, while long term effects is still wating for research.

OBJECTIVE: To detect the expressions of p-Stat3 and c-myc in human laryngeal squamous cell carcinoma (LSCC) tissue and Hep2 cell line, and to find the relationship between them. METHOD: Immunohistochemistry was used to detect the expressions of p-Stat3 and c-myc in 60 cases of LSCC and 30 cases of vocal cord polyp tissue. The protein levels of p-Stat3 and c-myc in Hep2 cell line was determined by immunocytochemistry. Western blotting was used to determine the protein levels of p-Stat3 and c-myc in Hep2 after treating with different concentrations of Stattic. RESULT: The positive rates of p-Stat3 and c-myc were 65% and 70% in the LSCC tissue, compared with that in the vocal cord polyp tissue, with significant difference (P < 0.05). The expression of p-Stat3 in LSCC tissue was associated with that of c-myc (r = 0.273, P < 0.05). The protein levels of p-Stat3 and c-myc were detected in the Hep2 cell line. Stattic inhibited Stat3 phosphorylation and c-myc in the Hep2 cell line in a concentration-dependent manner. CONCLUSION p-Stat and c-myc were up regulated in the tissue of laryngeal squamous cell carcinoma and the Hep2 cell line. Stattic inhibits the constitutively active p-Stat3 signaling pathway, and downregulats the expression of c-myc. The strong constitutive p-Stat3 signaling pathway in LSCC makes p-Stat3 a target for the development of novel therapeutic strategies.
Carcinoma, Squamous Cell ; metabolism ; pathology ; Cell Line, Tumor ; Head and Neck Neoplasms ; metabolism ; pathology ; Humans ; Immunohistochemistry ; Laryngeal Neoplasms ; metabolism ; pathology ; Phosphorylation ; Proto-Oncogene Proteins c-myc ; metabolism ; STAT3 Transcription Factor ; metabolism ; Signal Transduction ; Squamous Cell Carcinoma of Head and Neck