Objective To investigate the clinical and radiologic features of posterior reversible encephalopathy syndrome (PRES) associated with preeclampsia-eclampsia.Methods Twenty-one cases of PRES associated with preeclampsia-eclampsia were retrospectively studied on some aspects of clinical and radiologic features.Results The most common clinical presentations were seizures( 18 cases ),headache (16 cases),altered mentation (15 cases) and vision change (12 cases). Vasogenic edema lesions distributed in the parietal or occipital lobe (20 cases),the frontal lobes (14 cases),temporal lobes ( 11 cases), and basal ganglia (11 cases). The splenium involvement occurred in 4 cases,cerebellar hemispheres and brain stem involvement was prcscnted in 3 cases and 1 case separately. Three major patterns of PRES included dominant parietal-occipital (7 cases),the holohemispheric watershed (7 cases),and superior frontal sulcal (6 cases).Partial and asymmetric expression of PRES only occurred in 1 case.Conclusions The clinical features of PRES associated with preeclampsia-eclampsia are typical.Except the parietal or occipital lobe,involvement of the frontal lobe,temporal lobe and basal ganglia is common,followed by the occasional presence of the splenium,cerebellar hemispheres and brain stem.Three primary PRES patterns are noted,occasional with partial and asymmetric expression of PRES. Awareness of these typical and variable characteristics is important to recognize the PRES ncurotoxicity morc accurately when PRES present.

Objective To explore the differences between the minority nationality and Han recruits in army occupational adaptability.Methods 3 213 recruited youths coming from 29 autonomous counties of minority nationalities,Yunnan Province were tested by 2011 Chinese enrollment psychological test system to explore the differences of the intelligence adaptability and character trait adaptability between the minority nationality and Han recruits.Results There were obvious differences in the eligible rates of intelligence and character trait between minority nationality and Han recruits ( x2 =13.3,9.0; P ＜ 0.01 ).The intelligence eligible rates of Yi,Hani,Wa recruits (78.1％,76.8％,68.2％,respectively) were significantly lower than those of Han recruits (84.0％) (P＜0.01 ),and time used in three intelligence test was all significantly longer than Han recruits(P ＜ 0.05 ).Naxi and Dai recruits' time used in word reasoning ( ( 109.2 ± 20.9) s; ( 123.9 ± 32.5 ) s,respectively) was both longer than Han recruits' (P＜0.01).In the fact of character trait,the eligible rates of Hani,Wa recruits (67.8％,64.3％,respectively) were significantly lower than that of Han recruits (78.1％) (P ＜ 0.01 ).The Hani average score of T dimension (57.9 ± 17.5) was obviously higher than the Han's score (52.2 ± 16.5) (P ＜ 0.05 ).All dimensions average scores except T and D dimension of Wa recruits were all significantly higher than those in Han recruits(P ＜ 0.05 ).Conclusion Every minority nationality has its unique differences in armyoccupational adaptability from Han.Ethnic factor may be an important reference for new recruits' selection,education and management.

Objective To evaluate the effect of early rehabilitation and acupuncture on acute stroke. Methods125 cases stroke patients were divided into 4 groups: the early rehabilitation and acupuncture group, 34 cases(Group A); the early rehabilitation group, 39 cases(Group B); the early acupuncture group, 21 cases(Group C); and the control group, 31 cases. Bobath therapy and acupuncture were used. The CNS Damage Scale, Fugl Meyer Assessment(FMA), Modified Barthel Index(MBI), Clinical Therapeutic Effectiveness and Rehabilitation Efficiency were observed in all patients at the beginning, middle and end of the course. Results Rehabilitation Efficiency was the highest in Group A among all groups, and higher in Group B than in Group C and the control group, and higher in Group C than in the control group. The Clinical Therapeutic Effectiveness was better in Group A,B and C than in the control group, and better in Group C than in the control group. Conclusion It is a main and effective therapy to improve the patient\'s condition that early rehabilitation is combined with early acupuncture on acute stroke patients.

Objective To determine the expression of cathepsin D (CD), cathepsin H (CH) and cathepsin L (CL) in human primary hepatocellular carcinoma (HCC), and to investigate their mechanisms. Methods The protein expression of CD, CH and CL in hepatic specimens consisted of control (n = 17), HCC (n = 37) and paracancerous (n = 28) tissues were detected by immunohistochemistry. The relative values of CD, CH and CL protein expression were examined with absorbent density analysis. Data were analyzed using SPSS11. 5 software. The univariate analysis was used to compare the difference among groups. Results The mean absorbance of CD, CH and CL proteins in HCC tissues (1.21± 0.33, 0. 89 ± 0.22 and 1.16± 0. 25, respectively) were significantly higher in comparison with those in control tissues (0. 19 ± 0. 07, 0. 24 ± 0. 12 and 0. 28 ± 0. 14,respectively) and in paracancerous tissues (0.27±0.13,0. 31± 0.14 and 0. 36±0.15)(all P values =0.0001). Whereas there was no difference between control and paracancerous tissues with respect to CD, CH and CL proteins (P ＞0. 05). Three proteins immunohistochemically appeared as a lot of diffused spots and stripes staining in cytoplasma of HCC tissues,but only a few scatted spots staining was found in control and paracancerous tissues. Conclusion The high expression of CD, CH and CL protein in primary HCC may be important markers for carcinogenesis and malignant progress.

Objective In the two division methods which are GDP per capita gathering and administrative level division of the state, which method can more reflect regional economy on teenagers psychological characteristics influence. Methods 10684 recruited youths were tested by Chinese enrollment psychological test system,and the division method of GDP per capita gathering and administrative level division of the state was adopted.Results By the method of GDP gathering, the percent of pass from digital operation was higher in second class region to first class region(P＜ 0.05 ). The percent of pass from digital search was higher in first and second class of region compared to third class of region(P ＜0.05). For the Net dimension, the average value of third class region (52.28 ±10. 53 ) was obviously higher than that of first class region (50. 64 ±- 10. 17)and second class region (51.53 ± 10.28 ) (P＜0. 05 ). For the Dit dimension, the average value of third class region (52.83 ± 11.03 ) was obviously higher than that of first class region (50. 56 ± 10. 56 ) and second class region (51.80 ± 10. 81 ) (P ＜0.05 ). The average value of Set dimension of second class region (51.81 ± 10.72)and third class region (52.44±- 10.94) was evidently higher than that of first class region (49.90 ± 10.76 ) (P ＜ 0. 05 ). While through the administrative level division of the state, the percent of pass was apparently higher in city than in country for digital searching and words reasoning; Set dimension was distinctly higher in country ( 52.30± 10. 85 ) than in city (51.07 ±10.90)(P＜0.05). Conclusion The GDP per capita clustering method can better reflect the regional economy on teenagers psychological characteristics influence.

Sciatic neurectomy was performed on the right limb in 30 rats divided into three groups. On the first postoperative days, stainless steel capacitor plates were applied parallel to each other over the midtibial region of the right, neurectomized limb m each animal in the latter two groups, which were stimulated continuously with a 60kHz sinawave signal delivering 5-10V from peak to peak. The first group was served as controls and received no electrical stimulation. At the completion of 12d of electrical stimulation, all rats were sacrificed. A statistically significant enhancement of wet weight, dry weight, ashed weight, ultimate strength and bone density occurred in the stimulated, denervated tibiae of the experimental animals compared with the nonstimulated, denervated tibiae of the control animals. The results show that a sciatic neurectomized osteoporosis was prevented in the tibiae by a capacitively coupled electrical field.

Objective:To investigate the application value of laparoscopic duodenum-preserving pancreatic head resection (LDPPHR).Methods:The retrospective and descriptive study was conducted. The clinicopathological data of 25 patients undergoing LDPPHR in the Second Hospital of Hebei Medical University from November 2016 to November 2020 were collected. There were 7 males and 18 females, aged from 14 to 66 years, with a median age of 29 years. All the 25 patients underwent LDPPHR. Observation indicators: (1) surgical situations; (2) postoperative histopathological examination; (3) follow-up. Follow-up was conducted using outpatient examination or telephone interview to detect the recovery of patients up to March 2021. Measurement data with skewed distribution were represented as M (range) and count data were descripted as absolute numbers. Results:(1) Surgical situations: all the 25 patients underwent LDPPHR successfully, including 23 cases undergoing total pancreatic head resection and 2 cases undergoing subtotal pancreatic head resection. The operation time and volume of intraoperative blood loss of 25 patients were 310 minutes (range, 207 to 540 minutes) and 200 mL (range, 50 to 800 mL), respectively. Of the 25 patients, 1 case was infused with 4 U of red blood cells and 400 mL of plasma, 1 case was infused with 500 mL of plasma, 1 case was infused with 600 mL of plasma and the remaining 22 cases were not infused with red blood cells or plasma. Of the 25 patients, 3 cases with pancreatic fistula of class B were discharged after drainage, 4 cases had biliary fistula including 2 cases undergoing symptoms disappeared after implantation of common bile duct stent by endoscopic retrograde cholangiopancreatography, 1 case recovering well with drainage, 1 case with postoperative perihepatic effusion undergoing symptoms disappeared after the treatment of drainage and common bile duct stent implantation, and the remaining 18 cases had no complications. The duration of postoperative hospital stay was 17 days (range, 9 to 27 days) of the 25 patients. (2) Postoperative histopathological examination: the tumor volume of the 25 patients was 6.0 cm×5.0 cm×2.0 cm (range, 1.0 cm×2.0 cm×1.5 cm to 10.0 cm×9.0 cm×8.0 cm). Results of the postoperative histopathological examination showed that there were 12 cases with pancreatic solid pseudopaillary neoplasm, 4 cases with intraductal papillary mucinous neoplasm, 3 cases with serous cystadenoma, 2 cases with mucinous cystadenoma, 1 case with neuroendocrine neoplasm, 1 case with pancreatic true cyst, 1 case with cholesterol crystals combined with calcification in the center of pancreatic nodules and 1 case with cavernous hemangioma of pancreas. (3) Follow-up: all the 25 patients were followed up for 4 months to 48 months, with a median follow-up time of 27 months. During the follow-up, 1 case of the 25 patients with postoperative diabetes controlled blood glucose in the normal range after regular injection of insulin, 1 case with fatty diarrhea had symptoms improved after oral supplement of pancreatic enzyme preparation, 1 case with preoperative intermittent dizziness, weakness of both lower limbs and hypoglycemia had the level of blood glucose returned to normal without any special treatment after operation, and the remaining 23 cases had no metabolic complications. None of the 25 patients had tumor malignant transformation, recurrence or death. No long-term complications such as delayed gastric emptying, bile duct stones or stricture occurred to the 25 patients.Conclusion:LDPPHR is safe and feasible for the treatment of benign or low-grade malignant tumors of the pancreatic head, with the advantage of preserving the integrity of digestive tract.

The present study was designed to evaluate the protective effects of ethanol extracts of Rabdosia japonica var. glaucocalyx (Maxim.) Hara (RJ) on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice and the possible underlying mechanisms of action. The mice were orally administrated with RJ extract (16, 32 or 64 mg(kg(-1)) daily for consecutive7 days before LPS challenge. The ung specimens and the bronchoalveolar lavage fluid (BALF) were collected for histopathological examinations and biochemical analyses. Pretreatment with RJ significantly enhanced superoxide dismutase (SOD) activity and reduced the wet-to-dry weight (W/D) ratio, the levels of nitric oxide (NO) and protein leakage, and myeloperoxidase (MPO) activity in mice with ALI, in a dose-dependent manner. RJ reduced complement deposition and significantly attenuated LPS-induced ALI by reducing productions of inflammatory mediators, such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β). The results demonstrated that RJ may attenuate LPS-induced ALI via reducing the production of pro-inflammatory mediators, and reducing complement deposition and radicals.
Acute Lung Injury ; chemically induced ; drug therapy ; Animals ; Anti-Inflammatory Agents ; pharmacology ; therapeutic use ; Antioxidants ; metabolism ; pharmacology ; therapeutic use ; Complement System Proteins ; metabolism ; Inflammation Mediators ; metabolism ; Isodon ; chemistry ; Lipopolysaccharides ; Lung ; drug effects ; metabolism ; Male ; Mice ; Nitric Oxide ; metabolism ; Peroxidase ; metabolism ; Phytotherapy ; Plant Extracts ; pharmacology ; therapeutic use ; Superoxide Dismutase ; metabolism

[This corrects the article DOI: 10.1016/j.apsb.2019.01.003.].

Scavenging reactive oxygen species (ROS) by antioxidants is the important therapy to cerebral ischemia-reperfusion injury (CIRI) in stroke. The antioxidant with novel dual-antioxidant mechanism of directly scavenging ROS and indirectly through antioxidant pathway activation may be a promising CIRI therapeutic strategy. In our study, a series of chalcone analogues were designed and synthesized, and multiple potential chalcone analogues with dual antioxidant mechanisms were screened. Among these compounds, the most active not only conferred cytoprotection of HO-induced oxidative damage in PC12 cells through scavenging free radicals directly and activating NRF2/ARE antioxidant pathway at the same time, but also played an important role against ischemia/reperfusion-related brain injury in animals. More importantly, in comparison with mono-antioxidant mechanism compounds, exhibited higher cytoprotective and neuroprotective potential and Overall, our findings showed compound could emerge as a promising anti-ischemic stroke drug candidate and provided novel dual-antioxidant mechanism strategies and concepts for oxidative stress-related diseases treatment.