1.Pondering over the faculty and staff employment at institution of higher education
Journal of Chongqing Medical University 2000;25(z1):128-130
Qualified personnel are the source of social wealth and they are also the most active factor of the productive force. Nevertheless, planned economy severely hampers the initiative of the people working at institutions of higher learning. This article explores how the engagement system should be established so as to meet the needs of higher education. It is necessary to exert the market mechanism, carry out the principle of publicity, equality and competition, and choose the excellent ones by smashing the out-of-date management methods., and building a good environment where talents could demonstrate their ability, as a result, encourage the others. The current social insurance system should be reformed and set up the corresponding ones serving as guarantee of the personnel reform.
2.Thinking on the Engagement System for All College Staff
Chinese Journal of Medical Education Research 2003;0(02):-
The engagement system for all college staff has been imperative in the consistent deepening reform of personnel system in colleges and universities.This paper theoretically and practically discusses some specific issues met on the process of the reform from 5 aspects.
3.The Effect of Erythromycin on Nuclear Factor Kappa B and Intercellular Adhesion Molecule-1 in Airway Epithelium of Smoking Rat
Journal of Medical Research 2006;0(11):-
Objective To explore the anti-inflammatory therapeutic role of erythromycin in chronic obstructive pulmonary disease(COPD) by investigating the effect of erythromycin on the level of nuclear factor kappa B(NF-?B) and intercellular adhesion molecule-1(ICAM-1) in airway epithelium of smoking rats.Methods Wistar rats(n=30)with weighed(150?10) g each,20 were randomly sampled to be exposed to cigarettes smoking for four weeks then 10 of them were exposed wntinuously to cigaretts smoking for eight weeks as smoking,group,other loof them were intragastrically perfused by erythromycih before smoking as evythromycin group,the rest of total 30 rats as control group Then assessed expiratory airway resistance and lung compliance and observed the expression level of NF-?B and ICAM-1 in airway epithelium by using immunohistochemical method.Results(1) The expiratory airway resistance was increased and the lung compliance was degraded significantly in smoking group(5.67?0.32,4.39?0.40)(P
4.Application of New Zealand rabbit femoral puncture anti-leakage performance verification biodegradable mesh-like microporous balloon
Chinese Journal of Comparative Medicine 2014;(11):49-52
Objective Biodegradable is validated by the New Zealand rabbit femoral puncture mesh porous seepage prevention performance of the balloon.Methods The experiment was divided into the experimental group and control group, by piercing the New Zealand rabbit left leg near the femur, establish channel introduced after bone drill, fracture model is established, degradable mesh implant microporous balloon and/or bone cement.Observe and record the operation process of each New Zealand rabbit blood oxygen saturation change and cases of bone cement occur breakup and shortness of breath and groupings.Results Surgery under general anesthesia, bone cement injection process smoothly, balloon group of intraoperative breathing smooth, blood oxygen saturation has no obvious change; CPC group of blood oxygen saturation in the cement perfusion and perfusion after 81.63 +/-32.02, 32.02 +/-32.26, respectively, compared with perfusion 96.67 +/-1.71 in front of the difference is statistically significant, of which 3 cases died in 5 cases, shortness of breath, direct infusion of bone cement is more likely to lead to pulmonary embolism.Conclusions Further confirmed that the degradable mesh porous balloon seepage prevention of CPC and the breakup of the effect is obvious, comply with the design requirements.
5.The role of the airway remodeling in chronic obstructive pulmonary disease PGD 2 regulate TGF-β1
Jianying LIU ; Daishun LIU ; Zhenfeng LIU
Chongqing Medicine 2014;(27):3588-3591
Objective To explore PGD2 biological characteristics in L-929 mice lung fibroblasts cell by Laropiprant is a specific in-hibitor of PGD2 receptor regulation of TGF-β1/Smads signaling pathway .Provide further basis research to explore the molecular mechanisms of airway fibrosis .Methods The cells divided by Laropiprant concentration 0 .3 μmoL group ,1 .0 μmoL group ,3 .0μmoL group ,10 .0 μmoL group ,30 .0 μmoL and the control group .Each group were added TGF-β2 (2 .5 ng/mL) were cultured for 24 h after stimulation with the corresponding concentrations of Laropiprant 24 h ,TGF-β1 Smad3 and Smad4 expression were detected by PCR and WB ,respectively .A randomized approach ,using different concentrations of Laropiprant acts on cells at different times (12 ,24 ,48 ,72 h) by MTT assay for cell growth Laropiprant inhibition .Results TGF-β1 ,Smad3 and Smad4 mRNA expression de-creased with the addition of Laropiprant concentration increases ,there was significant difference compared with the control group with (P<0 .05) .TGF-β1 ,Smad3 and Smad4 protein expression decreased with the addition of Laropiprant concentration increases ,there was significant difference compared with the control group with (P< 0 .05) .Cell growth inhibition rate decreased with Laropiprant concentration increasing and cell culture time growth ,Laropiprant in concentration 1μml ,reaction time was 24 to 36 h ,the cell growth inhibition was significantly improved .Conclusion PGD2-DP1 expression in L-929 mouse lung fibroblasts cell may be associated with TGF-β1/Smads regulation .growth inhibition rate decreased with Laropiprant concentration increasing and cell culture time growth ,re-action time prolong ,the cell growth inhibition was significantly improved .
6.Clinical Observation on Combined Tuina and Medicated Bath for Early Intervention of Neonatal Brain Injuries
Zhenhuan LIU ; Jianying DING ; Chouping HAN
Journal of Acupuncture and Tuina Science 2010;08(5):310-314
Objective: To observe the clinical effect of early intervention of combined tuina with medicated bath for neonatal brain injuries.Methods: Brain-benefiting tuina manipulations,medicated bath and music plus exercise therapies were employed in 60 infants with medium or severe brain injuries.The Gesell measurement methods were adopted prior to and 3 months after treatment to evaluate the development quotient(DQ).In addition,the long-term follow-up was made after one and a half years.Result: The scores of DQ prior to treatment,3 month after treatment and 1.5 years after treatment were(34.98±28.94),(66.17±14.91)and(75.40±14.69)respectively,showing a marked improvement after 3months and 1.5 years of treatment(P=0.000).Conclusion: Early intervention using tuina manipulations could enhance the brain development,repair the nerve injury,improve the motion and cognitive ability and prevent the sequela of the nervous system.
7.Construction and Application of Fingerprint Management System of Narcotics
Ying ZHANG ; Xin FENG ; Jianying LIU
China Pharmacy 2007;0(28):-
OBJECTIVE:To provide a new management mode for the rational use and standardized management of narcotics in hospital.METHODS:The fingerprint management system of narcotics was build up and applied.RESULTS:The fingerprint management system of narcotics could accurately help identify patients' identity and provide effective supervision for using narcotics.CONCLUSION:The fingerprint management system of narcotics can replace the current management mode for it makes up the shortage of the traditional management system.
8.EFFECT OF GLUTAMINE SUPPLEMENTATION ON GLUTAMINE METABOLISM IN EXERCISING MICE
Zhengdong LIU ; Keji LI ; Jianying FENG
Acta Nutrimenta Sinica 1956;0(01):-
Objective: To approach the effects of glutamine supplementation on plasma and muscle levels of glutamine, and the activities of tissue glutamine synthetase and glutaminase after high intensity exercise. Methods: BAL/C mice were randomly divided into high intensity exercise(2% body weight load) and control groups to swim 2 hours per day for 8 weeks. Results: To compare with control group, high intensity exercise reduced glutamine levels in plasma and muscle by 74% (P
9.The experimental research of rat hepatoma immunotherapy using dendritic cells loaded with tumor antigens
Zhixiang ZHUANG ; Genshou LIU ; Jianying ZHOU
Chinese Journal of General Surgery 1997;0(04):-
0 05 by ? 2 test). The rats in intravenous groups (10 6,10 7) and in intratumoral group had significant prolonged survival (compared with control group, P
10.Detection of Mutations in the Wilms' Tumor Gene (WT1) in Leukemias
Qing LU ; Gexiu LIU ; Jianying HAN
Journal of Chinese Physician 2001;0(10):-
Objective To analyze mutations in the Wilms tumor gene (WT1) in Ieukemogenesis.Methods WT1 gene in peripheral blood was determined by PRC-SSCP technique,in 32 cases of acute leukemia,included 9 cases of acute granulocytic leukemia,8 cases of chronic granulocytic leukemia(mean age-33 years) and 16 specimens of normal subjects were also detected.Results Mutations in the WT1 gene in 3 of 32 leukemias were found .WT1 mutations were found in 11% of cases of acute lymphoblastic leukemia and in 13% of cases of acute myeloid leukemia,in which they were associtated with a poor response to chemotherapy.Conclusions The mutations in Wilms tumor gene WT1 are associated with leukemogenesis and its therapy,which WT1 transcripts may prove a significant tumor marker, as a MRD monitor in evaluating remission status and early relapse,and may be useful in prognosis of acute leukemia.