1.Comparative study of the effect in the therapy of Hepatic Cysts by image-guided percutaneous catheter dralnage and sclerotherapy
Jianye CHEN ; Weiming LIANG ; Qiaoqin PENG
Chinese Journal of Primary Medicine and Pharmacy 2012;19(14):2108-2109
Objective To compare the image guided effect between CT and Ultrasound for percutaneous catheter drainage and sclerotherapy in the treatment of hepatic cysts.Methods 26 patients with hepatic cysts underwent percutaneous catheter drainage and sclerotherapy by CT guided.87 cases underwent percutaneous catheter drainage and sclerotherapy by Ultrasound guided.Results 53 cysts underwent percutaneous puncture with 132 times by CT guided,and 5 cysts underwent sclerotherapy were failed(10.1%).231 cysts underwent percutaneous puncture with 267 times by Ultrasound guided,and 5 cysts underwent sclerotherapy were failed(2.1%).The failed rate of the two groups had statistifically significant difference(x2 =39.6875,P < 0.05).Conclusion In the image guided technique for percutaneous catheter drainage and sclerotherapy in the treatment of hepatic cysts,Ultrasound had more advantages,high accuracy,real time visual,high success rate,less damage,economy and convenience than CT.
2.Diagnosis and treatment of hydatidosis of retroperitoneum and bladder (Report of 9 cases)
Jianye XU ; Hongbing SI ; Dayong LIANG
Journal of Clinical Surgery 2001;0(01):-
Objective To investigate the diagnosis and treatment of Hydatidosis of post-peritoneum and bladder.Methods Nine cases were reported. Among them,one was epinephros-hydatid cyst,two renal hydated cyst,two hydatidosis of post-peritoneum in ileopelvic, and four bladder hydrated cyst. All cases had history of contacting with dog or sheep.Results All of the nine cases were cured by operation. Conclusions In percussion of the lower abdominal mass, hydrated cyst vibration, a specific sign, can usually be felt; and the mass do not disappear after urination. Besides, E-immune Test for echinococcus, B-ultrasonography, and CT are very useful diagnostic methods. Therefore, excision of the cyst still is the only effective treatment for hydatidosis.
3.Application of APACHE II scoring in ICU trauma patients.
Chinese Journal of Traumatology 1998;1(1):58-60
OBJECTIVE: To investigate the relationship between Injury Severity Score (ISS) and Acute Physiology and Chronic Health Evaluation (APACHE II) scores and mortality rate, and to evaluate the practical significance of APACHE II in ICU trauma patients. METHODS: ISS and APACHE II scores and mortality rate of 50 ICU trauma patients were calculated by AIS-1985 revision and Knaus method, then, compared and analyzed. RESULTS: The mortality rate was directly proportional to ISS and APACHE II scores in ICU trauma patients. APACHE II was more accurate and sensitive compared to ISS. CONCLUSIONS: APACHE II is a better predictor for ICU trauma patients. ISS>=25 or APACHE II>=20 may be used as the admitting criteria for ICU trauma patients.
4.Assessment of general and trace elements in CSF of patients with spinal cord injury
Zhongxin XIAO ; Hong DAI ; Jianzhong WANG ; Shaoting XU ; Jinnan ZHANG ; Liren ZHANG ; Bin JIA ; Feng ZHAO ; Jianye LIANG ; Song MA
Chinese Journal of Rehabilitation Theory and Practice 2003;9(12):717-718
Objective To analyze general and trace elements in cerebral spinal fluid (CSF)of patients with spinal cord injury (SCI). Methods To assess contents of general and trace elements (K, Na, Ca, Mg, Zn, Mn, Fe, Cu) in CSF of six SCI patients using ICP-AES. Results Compared with normal value, contents of Ca and Zn were significantly decreased (P<0.01), Fe and Mn were significantly increased (P<0.01), but no significant differences for Na, Mg, K and Cu in CSF of SCI patients. Conclusion The excitation of central nerve system in SCI patients may be higher than normal people indeed.
5.An Integrated Nomogram Combining Clinical Factors andMicrotubule-Associated Protein 1 Light Chain 3B Expression to PredictPostoperative Prognosis in Patients with Intrahepatic Cholangiocarcinoma
Liang CHEN ; Hongyuan FU ; Tongyu LU ; Jianye CAI ; Wei LIU ; Jia YAO ; Jinliang LIANG ; Hui ZHAO ; Jiebin ZHANG ; Jun ZHENG ; Yingcai ZHANG ; Yang YANG
Cancer Research and Treatment 2020;52(2):469-480
Purpose:
Microtubule-associated protein 1 light chain 3B (LC3B) serves as a key component of autophagy,which is associated with the progression of carcinoma. Yet, it is still unclear whetherLC3B is also an independent risk factor for intrahepatic cholangiocarcinoma (ICC). We aimto explore the predictive value of LC3B on prognosis of ICC, and to establish a novel andavailable nomogram to predict relapse-free survival (RFS) and overall survival (OS) for thesepatients after curative-intent hepatectomy.
Materials and Methods:
From August 2004 to March 2017, 105 ICC patients were eligibly enrolled in the ThirdAffiliated Hospital of Sun Yat-sen University. Preoperative clinical information of enrolledpatients was collected. Expression LC3B in the ICC specimen was detected by immunohistochemistry.
Results:
The 5-year RFS and OS in this cohort were 15.7% and 29.6%, respectively. On multivariateCox regression analysis, independent risk factors for 5-year OS were cancer antigen 125,microvascular invasion, LC3B expression and lymph node metastasis. Except for the above4 factors, neutrophil/lymphocyte ratio and tumor differentiation were independent factorsfor 5-year RFS. The area under the curve of nomograms for OS and RFS were 0.820 and0.747, respectively.
Conclusion
The nomograms based on LC3B can be considered as effective models to predict postoperativesurvival for ICC patients.
6.Efficacy analysis of the single versus combination drug therapies for benign prostatic hyperplasia with overactive bladder
Xinghui LI ; Jianye WANG ; Pengjie WU ; Huiping YUAN ; Xiaoquan ZHU ; Liang SUN ; Na SUN ; Xiangwen LI ; Rongqiang ZHANG ; Qiling LIU ; Ze YANG
Chinese Journal of Geriatrics 2018;37(10):1092-1097
Objective To explore the efficacy of the single versus combination drug therapies for benign prostatic hyperplasia(BPH) combined with overactive bladder(OAB).Methods A total of 471 outpatients with BPH and OAB meeting the inclusion/exclusion criteria were enrolled in this prospective cohort study from March 2012 to October 2015.Patients were divided into two groups:(1) the single alpha-blocker treatment group (prostate volume < 30 ml),and (2) the 5 alpha reductase inhibitors(5-ARIs) plus alpha-blocker combination treatment group(prostate volume ≥ 30 ml).The 318 patients were treated with alpha blockers for 4 weeks,and then received a continuing alpha-blocker treatment for 8 weeks if IPSS score changes were less than 30% (i.e.single alpha-blocker treatment group).And 153 patients were treated with 5-ARIs for 12 weeks,then received 5-ARIs plus alpha-blocker combination treatment for another 4 weeks(a total of 16 weeks)if IPSS score changes were less than 30 % (i.e.combination treatment group).The improvements of post-voiding residual(PVR),PV,maximum urinary flow rate(Qmax),international prostate symptom score(IPSS),overactive bladder symptom score (OABSS),quality of life (QOL),urine storage period symptom score (USPSS) and voiding symptom score(VSS)were compared between the two groups.Results The values of IPSS,OABSS,QOL,USPSS and VSS index in the two groups were improved after treatment as compared with pre-treatment(all P≤0.05).Patients in combination treatment group had little improvement in PVR and Qmax after treatment.The OAB symptom remission rates of BPH patients with OAB in single alpha-blocker treatment group were 70.5% (206/292)and 78.6% (165/210)after 4 and 12 weeks of treatment respectively.The OAB symptoms remission rates of BPH patients with OAB in combination treatment group were 54.5 % (64/122) and 67.1% (53/79) after 12 and 16 weeks of treatment respectively.Conclusions Both single alpha-blocker treatment and alpha-blocker plus 5ARIs combination treatment,which identification was based on prostate volume,have good effects on BPH patients with OAB.The single alpha-blocker treatment can improve PVR and Qmax,and the alpha-blockers plus 5ARIs combination treatment can improve the prostate volume in BPH patients with OAB.
7.Investigation of a Mycoplasma pneumoniae outbreak in a welfare institution
Jiaqi XIAO ; Jingyi CHEN ; Liang ZHANG ; Quanquan LIANG ; Jianye HU ; Jiewen YANG
Shanghai Journal of Preventive Medicine 2024;36(6):540-542
ObjectiveTo carry out an epidemiological analysis on an outbreak of Mycoplasma pneumoniae infection at a welfare institution to provide a theoretical basis for the corresponding prevention and control measures. MethodsUsing the method of field epidemiological investigation, special field treatment was carried out in September 2022. Serum samples from cases and close contacts in the same ward area were collected for detection of nine respiratory tract infection pathogens (Mycoplasma pneumoniae, chlamydia, influenza, human metapneumosis, respiratory syncytial, human boca, parainfluenza type 1‒4 virus, and Middle East respiratory syndrome, severe acute respiratory syndrome coronavirus) by immunofluorescence immunoglobulin M (IgM) antibody test. ResultsA total of 14 Mycoplasma pneumoniae cases were identified, all of whom were residents of the welfare institution. The first case occurred on September 4, while the last case was reported on September 13. The incidence rate of the fifth ward area where the first case reported was 12.82% (10/78), and it was 3.57% (3/84) in the third ward area and 1.20% (1/83) in the first ward area. There was a significant difference in incidence rates between ward areas (χ2=8.90, P<0.05), but no significant difference was observed in age distribution and length of hospitalization. Thirty-three samples were collected for detection of nine kinds of IgM antibodies against respiratory pathogens. The results showed that the Mycoplasma pneumoniae IgM antibody was weakly positive in the 14 cases. ConclusionBased on the epidemiological history, clinical symptoms and laboratory tests, it was concluded that it was an outbreak of Mycoplasma pneumoniae infection within the welfare institution. Welfare institutions should continue to control the occurrence and outbreak of infection through effective routine hygiene, ventilation, and disinfection so as to ensure the health and safety of their clients.