1.Effect of Meloxicam on nasopharygeal carcinoma CNE-1 cell line
Zhifang ZHOU ; Baoming SHEN ; Jianxuan LIAO
Chinese Archives of Otolaryngology-Head and Neck Surgery 2006;0(03):-
OBJECTIVE To study the effect of Meloxicam on the growth inhibition and apoptosis induction in nasopharyngeal carcinoma CNE-1 cell line.METHODS Technique of cell culture and randomized blank-contrast design were used.The degree and dose-dependency of Meloxicam which induced growth inhibition and apoptosis in CNE-1 cell line were observed by MTT method,AO+EB straining and flow cytomethy.COX-2 were determined using cell immunoflurorescence.RESULTS MTT assay showed that Meloxicam inhibite the growth of CNE-1 cells.AO+EB straining showed partial cells presented characteristic morphological changes of apoptosis.Flow cytometry analysis showed that treating CNE-1 cells with Meloxicam increase the percentage of apoptosis cells.Cell immunoflurorescence revealed that the COX-2 expression was decreased.CONCLUSION Meloxicam could significantly inhibit the growth and induce apoptosis of CNE-1 cells.Apoptosis of tumor cells is closely associated with down regulation of the ratio of COX-2.
2.Two kinds of intermaxillary traction influence the mandibular micro-implant and its surrounding:Three-dimensional finite element analysis
Gang ZHAO ; Jiajia WEI ; Xiaoping ZHANG ; Xu YUAN ; Jianxuan SHEN ; Wei ZHANG
Chinese Journal of Tissue Engineering Research 2013;(24):4444-4450
10.3969/j.issn.2095-4344.2013.24.011