1.Value of MicroPure imaging of ultrasonography in display of breast calcification: comparison with mammography
Shuni JIA ; Chunsong KANG ; Xiaoyan CHEN ; Jiping XUE ; Qingmei YANG ; Jianxiu FANG
Chinese Journal of Ultrasonography 2015;24(1):50-54
Objective To evaluate the value of MicroPure imaging system of ultrasonography in display of breast calcification,and explore its clinical application value.Methods One hundred and forty-one patients underwent by mammography,conventional ultrasound imaging and MicroPure imaging,the mammography results were reference standard,observing the display rate of MicroPure imaging for calcification,and the value of MicroPure imaging in the display of calcification with different shapes on mammography.As the pathologic diagnosis was golden standard,the accuracy of diagnosis of conventional ultrasound,conventional ultrasound combined with MicroPure imaging,conventional ultrasound combined with mammography were evaluated with receiver operating characteristic(ROC) curve.Results The display case of calcifications within breast masses:the specificity of MieroPure imaging was lower than conventional ultrasound(88.14% vs 100%,P < 0.05),the sensitivity and accuracy were higher than conventional ultrasound(100% vs 62.79%,93.14% vs 84.31 %,P <0.05).The display case of microcalcifications within normal breast tissue:the specificity and accuracy of MicroPure software system were lower than conventional ultrasound(9.26% vs 100%,43.87% vs 65.96%,P <0.05),the sensitivity was higher than conventional ultrasound (100% vs 20.00%,P <0.05).The punctate calcification,amorphous calcification,rough uneven,pleomorphic calcifications on mammography were all hyperechoic spots on MicroPure software system.The area under the ROC curve of the conventional ultrasound,conventional ultrasound combined with MicroPure imaging,conventional ultrasound combined with MicroPure imaging was 0.881,0.858,0.932,respectively.Conclusions MicroPure imaging has some clinical value on microcalcifications within breast masses,which can improve its sensitivity and accuracy.The specificity of MicroPure imaging diagnostic ultrasound imaging of microcalcifications were lower,and it can not distinguish between different shapes of calcifications.Compared with conventional ultrasound,MicroPure imaging system can not improve the accuracy of diagnosis of benign and malignant breast lesions.
2.Application of shear wave elastography in the study of renal tissue elasticity in patients with diabetic nephropathy
Jianxiu FANG ; Menghua XUE ; Chunsong KANG ; Xiaoyan CHEN
Chinese Journal of Ultrasonography 2018;27(10):869-874
Objective To investigate the clinical value of real-time shear wave elastography( SWE) in early diagnosis of diabetic nephropathy ( DN ) . Methods One hundred and fifty-five patients with type 2 diabetes mellitus (DM) in our hospital were selected as DN group and 54 healthy volunteers with matched age-sex were selected as control group . According to the criteria of Mogensen staging ,patients of DN group were divided into 3 subgroups according to urine protein/creatinine ( ACR) :group A ( DM or DN Ⅰ ,Ⅱ ) , ACR<30 mg/g ;group B ( DN Ⅲ ) ,ACR 30 -300 mg/g ;group C ( DN Ⅳ ,Ⅴ ) ,ACR> 300 mg/g . All subjects were examined by SWE technique to detect the maximum ,mean and minimum Young′s modulus values ( Emax ,Emean ,Emin) of the middle of left renal parenchyma ,the values of Young′s modulus in the control group and DN patients were compared . The relationship between Young′s modulus and ACR in patients with DN was analyzed . Results The Emax ,Emean and Emin in DN patients were all greater than those in control group ( P <0 .05) . In group A ,B and C ,Emax ,Emean and Emin gradually increased ( P<0 .05) . Spearman correlation analysis showed that there was a positive correlation between Young′s modulus and ACR in patients with DN ( r = 0 .817 ,0 .764 ,0 .609 ;all P= 0 .000) . ROC curve analysis showed that the area under the curve of Emax diagnosis DN Ⅲ stage was 0 .810 ,the cut-point value was 6 .65 kPa ,the sensitivity was 79 .0% ,and the specificity was 81 .7% ;the area under the curve of Emean diagnosis DN Ⅲ stage was 0 .785 ,and the cut-off value was 3 .69 kPa ,sensitivity 62 .8% ,specificity 78 .3% . Conclusions SWE technique can quantitatively analyze renal parenchyma hardness in patients with different stages of DN ,which may provide new diagnostic information for early diagnosis of DN .
3. Correlation between the maximum elastic modulus(Emax) shear-wave elastography and immunohistochemical profiles in breast cancer
Meihong JIA ; Haikang LI ; Jiping XUE ; Jianxiu FANG ; Shuai LI ; Chunsong KANG
Chinese Journal of Ultrasonography 2018;27(6):510-514
Objective:
To investigate the correlation between the maximum elastic modulus(Emax) of breast cancer obtained by shear-wave elastography (SWE) and immunohistochemical profiles.
Methods:
One hundred and sixty patients with 171 pathologically proven breast lesions were included in this study. All of them underwent conventional ultrasound and SWE examination before surgery. The Emax and maximum diameter were obtained. Histologic grade, immunohistochemical profiles ER, PR, HER-2, Ki-67 and molecular subtypes were recorded according to pathological results after surgery. The correlation between Emax and tumor size, histological grade, ER, PR, HER-2, Ki-67 and molecular subtypes were analyzed.
Results:
①There was a positive correlation between the tumor size with Emax(