Neurogenesis is sustained throughout adulthood in the mammalian brain due to the proliferation and differentiation of adult neural progenitor cells found in the subventricular zone of the lateral ventricles and subgranular zone of the dentate gyrus. This review covers recent findings that elucidate different aspects of regulation of neurogenesis, including proliferation, migration and differentiation into mature neurons and functional integration into the existing neural circuits. Furthermore, this review also discusses the effects of pathological conditions on adult neurogenesis in both rodent models and human patients as well as some of the potential problems or limitations in neurogenesis research, which may shed some light on developing novel research strategies for replacement treatment of neurological disorders.

The basic nursing quality is an important dial of the general administration level and the basic personnel quality of a hospital.Many causes have led to the down trend of the basic nursing quali- ty.After a specific analysis of the causes of such a trend,important measures and solutions have been put forth,The first is to strengthen the moral education of the profession and upgrade the quality of the nursing staff.The second is to adopt the "group responsibility" administration and gradually carry out a systimatic integrated nursing so that a transformation of nursing models is put to practice,The third is to broaden the outlet of human resources so that personnel are rationally employed and the rate of job— taking raised.The last one is to heighten the initiative of the nursing staff through the rational opera- tion of the "incentive"mechanism in accordance with the law of values.

Objective: To investigate the quality control for purpose of radiologic protection in beside Photography. Methods: From a clinical application, based on the thress principle of radiological protection, combined with years of clinical experience, the need for comprehensive study bedside photography and protection security. Depending on the situation ,put forward corresponding countermeasures. Results: The different patient, especially in children photography and treatment of critically ill patients, with a reasonable operation mode, the method can reduce the radiation. Conclusion:The widespread popularity of medical radiological protection education, strengthen the quality control of bedside photography on bedside X-ray photography protection is very useful.

Objective: To explore the feature of theory of mind(ToM) in schizophrenic patients and the influencing factors. Methods: Subjects were 108 patients with schizophrenia, 21 with affective disorders and 21 normal subjects. Picture-story tasks, PANSS and WAIS-R were used to assess the patients' ToM, symptoms and intelligence. Results:It was found that the scores on first-order theory of mind tasks of schizophrenic patients with IQ below 70 were lower than normal subjects'(D = -56.58,P

Objective To determine species, counts, and seasonal variation of airborne pollen in the center of Nanchang. Methods Pollen counts were done with Durham gravity method on the top of the building in the campus of Jiangxi Medical College, Nanchang, April 1, 2000-March 31,2002. Results There were airborne pollens in all seasons of the year in atmosphere of Nanchang, which included about 47 species. The highest airborne presence (percent of total yearly pollen counts) was for Ambrosia(35.73%); followed by Pinaceae (15.94%), Artemisia (11.94%), Gramineae (5.88%), Cupressaceae (5.64%), Cunningha-mia R.Br.(5.12%), Chenopodium-Amaranthus (5.03%) , and Humulus(2.02%). The dispelling period showed a double curve: the first peak occured in Mar. and Apr. (22.56% and 11.98% respectively). The predominant pollens were tree pollen (Pinaceae, Cupressaceae, Cunninghamia R.Br., Moraceae and Salix). The second peak occured in Aug., Sep., and Oct. (9.61%, 23.77%, 19.57% respectively). The predominant pollens were grass pollen (Ambrosia, Artemisia, Gramineae, Chenopodium-Amaranthus and Humulus). Gramineae had been scattering all seasons, but it's counts were not high in every month. Conclusion There are airborne pollens dispelling in atmosphere of Nanchang in the whole year, whose dispelling period shows a double curve (the first peak occurs in Mar. and Apr. And second peak occurs in Aug. Sep. and Oct.) and the predominant pollens are Ambrosia, Pinaceae, Artemisia, Gramineae, Cupressaceae, Cunninghamia R.Br., Chenopodium-Amaranthus and Humulus. This study provides useful scientific information for production of specific allergen and for clinical prevention, specific diagnosis, specific therapy of allergic deseases.

To examine the occurrence of neuron activation,neurodegeneraion and cell death,and the correlation among them in the hippocampus after status epilepticus.Methods CFV,Fluoro Jade B and c-Fos staining were done at multiple time points after pilocarpine induced status epilepticus.Results In the stratum granulosum of dentate gyrus,c-Fos positive neurons increased significantly at 1 h,2 h and 1 d after status epilepticus (P ＜0.01 or 0.05).However,almost no Fluoro Jade B staining cell was found in the stratum granulosum in the experiment and control groups,and no obvious difference was shown on the numbers of CFV staining cells in this area among all groups.In the hilus of dentate gyrus of different groups,there were no c-Fos positive neurons in all groups.In the hilus,the number of Fluoro Jade B staining cells significantly increased at 2 h and 1 d after the status epilepticus (P ＜0.01 ),and the number of CFV staining neurons dramatically decreased 1 d after the status epilepticus ( P ＜ 0.01 ) compared with the control.In the stratum pyramidale of CA1,the numbers of c-Fos positive neurons at 30 mim,1 h,2 h and 1 d,and Fluoro Jade B staining cells at 2 h and 1 d after the status epilepticus significantly increased (P ＜ 0.01 or 0.05 ),while no obvious difference in the number of CFV staining cells in the stratum pyramidale of CA1 among different groups was shown.Conclusion There is no direct correlation among cell activation,neuron degeneration and cell death in the hippocampus of mice after pilocarpine induced status epilepticus.

Objective To evaluate the difference of adaptive exposure dose in two digital X-ray imaging systems. Methods Resin phantom and contrast-detail test phantom were used on Cesium iodide and Gadolinium oxide sulfide plate imaging detector DR systems using difference exposure parameters. All entrance surface dose were recorded, Image quality index (IQFinv ) was calculated by CDRAD analysis software. The optimal exposure radiation dose was determined according to the sensitivity and IQFinv. Results There were no significant differences of entrance surface dose between two digital X-ray systems on two different exposure parameters with 70 kV ( P > 0. 05) , while there were significant differences with 125 kV(P < 0.05) . The maximum difference was 28. 57% . The mean IQFinv value of Cesium iodide detector DR and Gadolinium oxide sulfide detector DR with 125 kV and 70 kV were 4. 89 ±1. 01 and 2.47 ±0.25, 5. 10 ±1.05 and 2.38 ±0.43, respectively. There were significant diferences between the two systems under the same exposure parameters (t = 6. 509,10. 158, P < 0. 05). The optimal exposure dose ratio between Cesium iodide and Gadolinium oxide sulfide detector DR system was 1:2. Conclusion According to the IQFinv value, the adaptive exposure parameter can be adjusted to achieve good image quality with low radiation dose on different digital radiography systems.

Piplartine is an alkaloids/amide component of Piper species,having diverse pharmacological and biological activities.Recent studies have indicated that piplartine has inhibitory effects on several kinds of tumors and is a kind of potential antitumor drugs.It can inhibit the proliferation of tumor cells,cause cell cycle arrest and induce apoptosis.More investigations suggest that targeting the reactive oxygen species(ROS) stressresponse pathway is closely related to its antitumor activity.

Objective To understand the infection situation and epidemiological characteristics of Mycoplasma pneumonia (MP) among children with MP infections in Guilin area .Methods The IgM antibody of MP was determined in 1 704 pediatric outpatients and inpatients with respiratory tract infections in our hospital during 2015 by using the MP IgM antibody test reagent kit(colloidal Gold method) .The detection situation was investigated and analyzed .Results The total MP positive rate among children patients with respiratory tract infections in Guilin was 18 .19% ,the female was higher than male with statistical difference (22 .48% vs . 15 .37% ,P<0 .05) .The MP positive rates in children 0 - <1 years old ,1 - <3 years old ,3 - <6 years old and 6 -14 years old were 6 .25% ,18 .59% ,25 .56% and 32 .40% respectively ,and the differences were statistically significant (P<0 .05) .The MP posi‐tive rates in spring ,summer ,autumn and winter were 21 .56% ,15 .29% ,16 .52% and 18 .48% respectively ,and the differences were not statistically significant(P>0 .05) .Conclusion MP is one of the most common pathogens leading to respiratory tract infection in children ,its infection shows gender and age differences .Summer and autumn are mainly epidemic seasons .Children aged 6―14 years old are susceptible to be infected by MP .So it is necessary to strengthen the prevention of MP infection .

Objective To compare the levels of serum CEA, NSE and CYFRA21-1 of patients with lung cancer and those with benign lung diseases, and to evaluate the clinical differential diagnostic value of combined detection of serum CEA, NSE and CYFRA21-1 in patients with lung cancer. Methods CEA, NSE and CYFRA21-1 were determined with enzyme-linked immunosorbent assay in 122 patients with lung cancer and 37 patients with benign lung diseases. The data was analyzed by t test. Results The serum levels of CEA(12.95?33.04ng/ml), CYFRA21-1(4.87?0.638ng/ml) in patients with lung cancer were significantly higher than that in those with benign lung diseases (1.92?0.84ng/ml and 4.87?0.638ng/ml, respectively)(P0.05). The levels of serum CEA, NSE and CYFRA21-1 were related to types of pathology. The highest levels of CEA, NSE and CYFRA21-1 appeared in adenocarcinoma, small cell carcinoma and squamous cell carcinoma, respectively. The level of serum of NSE (26.05?20.69ng/ml) in patients with small cell carcinoma was significantly higher than that of the patients with benign lung disease, adenocarcinoma (11.26?6.97ng/ml) and squamous cell carcinoma (12.71?7.64ng/ml), respectively (P0.05). Conclusion Combined determination of serum levels of CEA, NSE and CYFRA21-1 is helpful in differential diagnosis of lung cancers.