2.To observe the curative effect of paracentesis and plaster mold compression fixation for the treatment of pseudocyst of auricle.
Xiaohui DU ; Jianxin YUE ; Wangyan CHEN
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2013;27(10):494-495
Adult
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Casts, Surgical
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Cysts
;
surgery
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Ear Auricle
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Female
;
Humans
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Male
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Middle Aged
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Paracentesis
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Treatment Outcome
3.Operation pathways for sphenoidal sinus by nasal endoscope and treatments for correlated diseases beyond scope of sphenoidal sinus
Jianxin YUE ; Weijia KONG ; Song ZHANG ; Yanjun WANG ; Xiaomeng ZHANG
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2009;(20):920-922
Objective:We probe more direct operation pathways in sphenoidal sinus and saddle area, and take proper measures for correlated diseases which surpass scope of sphenoidal sinus by combining image data, which could prevent serious complication.Method:Under nasal endoscope, the operation approaches we adopted included trans-anterior ethmoid sinus-posterior ethmoid sinus-sphenoidal sinus pathway, trans-meatus nasi superior-posterior ethmoid sinus-sphenoidal sinus pathway, trans nasal septum-sphenoidal sinus pathway and trans-natural opening of sphenoid sinus anterior into sphenoid sinus pathway by taking upper edge of posterior naris as a consistent surgical landmark. Forty-six cases who had sphenoidal sinus mass with bone erosion recieved surgical treatment.Result:Twenty-one cases with cyst and pus cyst of sphenoidal sinus had been healed by trans-meatus nasi superior pathway;1 case with hematoma and organization in sphenoidal sinus had been cleared by trans-meatus nasi superior pathway;3 cases had hematoma and organization in sphenoidal sinus and pseudoaneurysm in internal carotid artery,one of them suffered fatal hemorrhage in surgical exploration, and cured by endovascular embolization, the other two only underwent nasal endoscopic examination,the diagnosis was established by DSA and they received interventional therapy;4 cases with papilloma in sphenoidal sinus had been treated by trans-natural opening of sphenoid sinus approach,and 3 cases were cured,1 case had only partial mass resection as the papilloma offended the outer wall of sphenoidal sinus diffusely;2 cases with cholesteatoma of sphenoid sinus have been removed completely by trans-meatus nasi superior approach;1 case with encephalomeningocele of sphenoidal sinus underwent sphenoidotomy by trans-natural opening of anterior of sphenoidal sinus, and intraoperative puncture showed characteristic cerebrospinal fluid,the exposed meninges were then repaird surgically;1 case with mycosis of sphenoidal sinus had been cured by thorough clearing of the leision in sphenoidal sinus combined with antifungal therapy;3 cases with malignancy of sphenoidal sinus had received major mass resection of sphenoidal sinus by trans-anterior ethmoid sinus-posterior ethmoid sinus approach, and followed with radio therapy and chemotheraphy;5 cases with NPC in-volving sphenoidal sinus had been treated by radio therapy and chemotherapy after pathological examinacation;5 cases with post-operative cerebrospinal rhinorrhea and granulation hyperplasia of sphenoidal sinus had been repaired successfully by trans-meatus nasi superior approach or tans-nasal septum approach.Conclusion:There are various surgical pathways to deal with sphenoidal sinus and correlated diseases under nasal endoscope.The operation will be direct, safe and minimal invasive if we choose the pathway properly. Thin slice CT scan and 3D reconstruction of sella, and DSA or angiography of brain before operation is one of effective means to prevent surgical complications for leisions beyond scope of sphenoidal sinus.
4.Effect of empathy, forgiveness on urban residents' life satisfaction
Yue LIU ; Mingjie ZHOU ; Li WANG ; Xiaoshan LI ; Jianxin ZHANG
Chinese Journal of Behavioral Medicine and Brain Science 2013;22(7):633-635
Objective To explore the effect of empathy and forgiveness on urban residents' life satisfaction.Methods Interpersonal Reactivity Index(IRI),Trait Forgivingness Scale(TFS) and the Satisfaction with Life Scale(SWLS) were administrated to 3537 participants living in several provinces in China.Results ①The variable of perspective-taking had significant main effect on both forgiveness and life satisfaction(β=0.409,P <0.01 ; β=0.145,P <0.01),and particularly personal distress had significant negative effect on both forgiveness and life satisfaction (β=-0.291,P < 0.01 ; β=-0.181,P < 0.01)②Forgiveneas had significant main effect on life satisfaction(β=0.142,P<0.01).③The relationship between perspective-taking and life satisfaction was partially mediated by forgiveness(P<0.01).The relationship between personal distress and life satisfaction was also partially mediated by forgiveness (P < 0.01).Conclusion Perspective-taking and personal distress has different predicting effect on life satisfaction,and forgiveness plays an important mediating role in the relationship between them.
5.Effects of three Chinese formulas on BDNF,TrkB in rat contex and hippocampus with chronic immobilization stress
Jiaxu CHEN ; Wei LI ; Xin ZHAO ; Hongyan XU ; Zhufeng WANG ; Guangxin YUE ; Jianxin YANG
Chinese Journal of Pathophysiology 2000;0(07):-
AIM:To investigate the changes of brain-derived neruotrophic factor(BDNF),tyrosine kinase B(TrkB) in rat cortex and hippocampus with chronic immobilization stress and the influence of three Chinese formulas(Xiaoyaosan,Sijunzitang,Jinkuishenqiwan) on them.METHODS:Chronic immobilization stress method(180 min daily,repeated 7 days or 21 days) was taken,and the changes of BDNF,TrkB in rat forehead cortex and hippocampus CA1 were measured by immunohistochemistry integrated image analysis.RESULTS:The contents of BDNF in rat forehead cortex and hippocampus CA1 were obviously lower in the model group of 7 days and 21 days than those in the normal control group(P
6.Association between STAT3 gene and children with acute lymphoblastic leukemia
Peiwei ZHAO ; Xin YUE ; Hao XIONG ; Jianxin LI ; Hui LI ; Xuelian HE
Chinese Journal of Applied Clinical Pediatrics 2016;31(15):1152-1155
Objective To investigate the association between single nucleotide polymorphism (SNPs) (rs1053005 and rs744166) and expression level of STAT3 gene and the susceptibility to acute lymphoblastic leukemia (ALL) in Chinese children.Methods A case-control study was performed,and 184 children with ALL and 377 healthy children as controls were recruited.The genotypes of 2 SNPs were detected by using polymerase chain reaction-restriction fragment length polymorphism method.And the expression level of STAT3 gene was detected by using real-time PCR;All the data were analyzed by using SPSS 16.0 software.Results (1) In this study,the genotypes (GG,AG,AA) of rs1053005 had a significant difference between the ALL group and control group (x2 =6.737,P =0.034).Compared with control group,the A allele had a higher frequency in ALL group and A allele was a risk factor(x2 =5.853,P =0.016).But,there was no difference in frequency of genotype rs744166 between the 2 groups (x2 =1.866,P =0.393).(2) There was no significant association between genotypes and risk degree among 3 groups (high risk group,medial risk group and standard risk group) (x2 =0.335,P =0.987).(3) The expression level of STAT3 gene in patients with AA genotype was lower than that of the patients with GG genotype (t =4.758,P =0.009);and compared with patients of the standard risk group,high risk patients had a lower expression level of STAT3 gene (t =5.284,P =0.007).Conclusions The polymorphism of SNP rs1053005 was associated with ALL,with A allele being a risk factor;and the expression level of STAT3 gene maybe associated with the risk degree in ALL patients.
7.Vascular endothelial growth factor165-regulated nasopharyngeal carcinoma cell lines invasion and migration involve expression and activation of matrix metalloproteinase-2.
Yanjun, WANG ; Weijia, KONG ; Jianxin, YUE ; Dawei, SUN ; Wei, LI ; Qi, YAO ; Yu, SUN ; Jihua, DONG
Journal of Huazhong University of Science and Technology (Medical Sciences) 2006;26(5):621-4
The effect of vascular endothelial growth factor (VEGF) overexpression on matrix metalloproteinase-2 (MMP-2) in nasopharyngeal carcinoma (NPC) cells in vitro and the possible mechanism involved were investigated, and the correlation between the expression of VEGF and MMP-2 in NPC evaluated. The NPC cells were transfected with PAd-trackVEGF165 plasmid. The expression levels of VEGF and MMP-2 mRNA and protein in NPC cells were detected by semi-quantitative RT-PCR and Western blot respectively. It was found that the expression of VEGF and MMP-2 mRNA and protein was significantly increased in NPC cells after transfection of VEGF165. It was concluded that the expression of VEGF was correlated to the in vitro invasion of NPC cells, and the induction of MMP-2 by VEGF was a key process of NPC cell invasion.
8.Dysregulation of E-cadherin in chronic rhinosinusitis with nasal polyps.
Weijia, KONG ; Junhua, WU ; Yanjun, WANG ; Jianxin, YUE ; Song, ZHANG ; Yanping, YU
Journal of Huazhong University of Science and Technology (Medical Sciences) 2010;30(4):509-13
E-cadherin is a key epithelial protein and adhesive molecule. This study detected the E-cadherin expression in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and controls, and analyzed its possible role in the pathogenesis of CRSwNP. The expression of E-cadherin was detected by using Western blotting and immunohistochemistry in controls and patients with CRSwNP. Computed tomography (CT) scan findings were scored. The results showed that the E-cadherin expression was up-regulated in patients with CRSwNP as compared with controls (P=0.039) and the positive staining was predominantly localized on the epithelial cell membrane. E-cadherin level was correlated negatively with Lund-Mackay scores in patients with CRSwNP (r=-0.604, P=0.005). It is suggested that E-cadherin may be involved in the pathogenesis of CRSwNP and correlated with disease severity.
9.The key points to the successful repair of cerebrospinal fluid rhinorrhea.
Xia WU ; Yanjun WANG ; Jianxin YUE ; Gang ZHONG ; Yun ZHU ; Weijia KONG
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2014;28(9):618-620
OBJECTIVE:
To summarize the clinical experience of endoscopic repair for cerebrospinal fluid (CSF) rhinorrhea in our department in the last 4 years.
METHOD:
Clinical data of 16 patients with CSF rhinorrhea who underwent nasal endoscopic repair was analyzed retrospectively. The effect of etiology, image data, location of CSF leaks and surgical techniques on treatment were discussed.
RESULT:
Among the 16 patients, 10 were diagnosed with spontaneous CSF rhinorrhea, 2 were diagnosed with traumatic CSF rhinorrhea, 3 were diagnosed with CSF rhinorrhea after catching cold and 1 was diagnosed with meningo-encephalocele in with CSF rhinorrhea. The leak was located by CT scan in 11 cases, by MRI in 7 cases. The common locations of the defect were the frontal sinus (3 cases), cribriform roof (3 cases), sphenoid sinus (6 cases) and the nasal cavity top (4 cases). All the cases were successfully cured after the first nasal endoscopic repair with autologous materials. None of patients had a reoccurrence during 10 to 42 months follow-up time.
CONCLUSION
The application of CT and MRC before surgery which could make an accurate diagnosis of the location and the size of the defect. The correct selection of repair materials, processing planting bed around the leakage and complete contacting leakage with graft bed are the key points to the successful surgery of CSF rhinorrhea.
Adolescent
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Adult
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Cerebrospinal Fluid Rhinorrhea
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surgery
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Child
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Endoscopy
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Female
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Follow-Up Studies
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Humans
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Male
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Middle Aged
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Retrospective Studies
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Treatment Failure
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Treatment Outcome
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Young Adult
10.The diagnosis and treatment of traumatic pseudoaneurysm of internalcarotid artery in sphenoid sinus(a report of 6 cases)
Jianxin YUE ; Weijia KONG ; Chengzhang YANG ; Song ZHANG ; Yanjun WANG ; Xiong CHEN
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2009;(18):843-845
Objective:In order to prevent misdiagnosis and degrade death rate, we explored the early diagnosis and correct treatment methods of traumatic pseudoaneurysm of internal carotid artery in sphenoid sinus,. Method: The clinic data of 6 cases who had traumatic pseudoaneurysm of internal carotid artery in sphenoid sinus and were admited in our hospital were analyzed retrospectively. Large numbers of literature about the disease were re-viewed. Some early diagnosis methods and optimal treatment schemes were proposed. Result: All patients had a history of cranium trauma and recurrent attacks nasal hemorrhage. There are two patients with a complication of sight loss in single eye. In the six cases, one case was treated with unilateral common carotid artery ligation, three cases were treated with aneurysm and internal carotid artery embolism by using sacculus proprius which is able to shedding , one case was treated with internal carotid artery embolism by using tiny circlip ring . These five pa-tients were crued with no severe complication. One patient death of hemorrhea. His nasal cavity was tamponaded repeatly because repeat nasal hemorrhage. However, he had never treated with internal carotid artery embolism. Conclusion:The patients who have traumatic pseudoaneurysm of internal carotid artery usually die of unmanageable hemorrhea. The patients may be cured if they could obtain an early diagnosis and correct treatment.