1.Diagnosis and treatment of functional delayed gastric emptying after subtotal gastrectomy:a report of 53 cases
Weishan XUE ; Shaojie SUN ; Jianjun XIN ; Jiantian LI ; Bo HAN
Chinese Journal of General Surgery 2000;0(11):-
ObjectiveTo determine the possible causes for functional delayed gastric emptying (FDGE) and its diagnosis and treatment. MethodsThe clinical data of 53 FDGE patients after subtotal gastrectomy from 1987 to 2001 were retrospectively analysed. ResultsAll the 53 patients were recovered and discharged. Among them, 11 were misdiagnosised as mechanical ileus and were reoperated on. ConclusionsThe main cause of FDGE may be the disturbance of gastrointestinal motility which may be caused by vegetative nerve injury during the operation. The main therapy is non-surgical treatment and reoperation should be avoided at the early stage.
2.Pathological characteristic of Alzheimer's disease produced by lesion in nucleus basalis of Meynert in rats
Lin LI ; Xiaomin AN ; Jiantian QIAO
Chinese Medical Journal 1998;111(7):638-640
Objective To find out if the lesion in nucleus basalis of Meynert (nbM) can induce some morphological changes characteristic of Alzheimer's disease.Methods Kainic acid was injected into nbM of the rats, and the behavioral deficiency and the morphological changes in the cortex and hippocampus were observed by methenamine silver staining and electron microscopical examination.Results After 9-15 months of breeding following nbM-lesion, we observed many pathological changes in this animal model, which were characteristic of Alzheimer's disease in human, and especially we could find for the first time the formation of senile plagues after 15-month breeding.Conclusion It is proposed that the degeneration of nbM neurons might be primary and responsible for the pathological changes in other brain tissues in sporadic Alzheimer's disease.