Objective To Summariz and discuss the adverse reactions of Niuhuang-Jiedu pill (NJP) in the treatment.Methods Retrieved ADR report literatures through Chinese Medical Journal Database (CMJD) and WANFANG DATA from 1970 to 2012 with NJP as the key words,got and analyzed datas including patient age,gender,dosage,medication time and ADR type.Results Sixty-eight literatures with seventy-seven ADR report cases were retrieved.Adverse action induced by NJP was mainly allergic response,including arseniasis,gastrointestinal,uropoiesis reactions.Among 77 ADR cases,47 cases were considered as allergic response,61.0％ of the total,one death and thirteen shock cases were included.The number of arseniasis,gastrointestinal,uropoiesis reactions cases were respectively 14.3％,11.7％,6.5％ of the total.Conclusion The ADR of NJP should not be ignored.Allergy history,dosage and medication time should be pay more attention to to prevent the ADR of NJP to the fullest extemt.

Objective In order to investigate the situation application of compound Danshen injection (CDI) in the treatment and to provide reference for clinical rational use.Methods Adverse drug reactions (ADR) report literatures through WANFANG DATA, VIP DATA and CNKI from 1989 to 2013 with (CDI) were retrieved the data including patient age, gender, medical history, dosage, medication time and ADR type were got and analyzed.Results One hundred and twenty-one literatures with one hundred and forty-eight ADR report cases wore retrieved. The ADR of (CDI) rate of male was higher than female. The original disease causes were cardiovascular and cerebrovascular diseases. The age, a rather elderly bunch, was not associated with the disease. The frequent onest time of adverse reaction was in 5-20 min after medication, and allergic reaction was the main adverse reaction.Conclusion The ADR of CDI should not be ignored. Patients constitution, gender, medication time and the combined application should be pay more attention to reduce the incidence of ADR and ensure the drug safety.

OBJECTIVE:To systematically review the efficacy of Berberine hydrochloride tablet in the treatment of non-alco-holic fatty liver disease(NAFLD),and provide evidence-based reference for the clinical treatment. METHODS:Retrieved from CJFD,Wanfang Database,VIP,CBM and PubMed,observational studies about Berberine hydrochloride tablet in the treatment of NAFLD were collected. After data extraction and quality evaluation,Meta-analysis was performed by using Rev Man 5.3 statistics software. RESULTS:A total of 6 studies were included,involving 294 patients. Results of Meta-analysis showed Berberine hydro-chloride tablet could significantly reduce the levels of AST[WMD=18.97,95%CI(2.25,35.70),P=0.03],ALT[WMD=31.04, 95%CI(7.17,54.91),P=0.01],TG[WMD=1.07,95%CI(0.39,1.74),P=0.002] and TC[WMD=1.31,95%CI(0.79,1.84),P<0.001] in the serum of patients with NAFLD. There were significant differences. CONCLUSIONS:Berberine hydrochloride tablet can significantly improve the liver function and blood lipid levels of patients with NAFLD,and the clinical efficacy is relatively pre-cise. Due to the limit of methodological quality,it remains to be further verified by large-scale and high quality RCT.