From August 1996 to October 2004,totally 22 patients(22 eyes) of entire blepharocoloboma after malignant palpebrae superior tumorectomy,admitted to Department of Ophthalmology in the Affiliated Hospital of Binzhou Medical College,were repaired with sclera transplantation for the eyelid reconstruction.The alcohol-preserved scleral allograft was utilized for a substitute of tarsal plate.The internal surface of scleral graft was covered with remaining fornical conjunctiva and the external surface with musculus orbicularis oculi and skin.Bilateral sutures were fixed on the stump of tarsal plate or exterior and interior external palpebral ligament.Then eyelid margin was sutured and cut off after 6 months.All patient were followed up after operation for average 28.8 months.No reject reaction was found,catacleisis was fine and external appearance was satisfying.The eyelid reconstruction with scleral allograft is effective to keep eyelid normal function and external appearance.