Plasma fibronectin (PFn) was determined serially by both simple radial immunodiffusion (RID) and improved indirect hemoagglutination test (using gelatin-coated sheep RBC) in the serum of 30 patients with severe viral hepatitis (SVH),100 normal subjects,and 30 patients with chronic active hepatitis (CAH).Liver function,serum C3 and immunoglobulin (Ig) were determined simultaneously.Endotoxin was assayed by Limulus lysate test in 21 patients with SVH.The normal value of PFn was 284.31?45.56?g/ml and 1:30.64 (geometrical mean).The PFn level significantly decreased in patients with SVH.Significant correlations were found between PFn levels and the values of total serum bilirubin,prothrombin time,C3 and IgM.Low PFn levels were remarkably associated with the occurrence of endotoxeamia.Serial determinations of PFn in serum can reflect the severity of the illness and prognosis in the patients with SVH.

The key point to define the psychological problem in children is the grasp of degree,also,the key point to educate children is the grasp of degree.Are there some principles to clarify the degree? How to quantify the degree? This paper brought forward the gold zone method of psychological guidance in children and adolescents and defined its quantitive expression as golden section.The gold zone method can grasp the scale set according to the goal,form the proper consumption value,control the interpersonal intimacy,cultivate fine thinking and behavioral pattern,and give appropriate guidance to many basic problems about children's growth.

The quality of clinical trials in traditional Chinese medicine (TCM) was analyzed with respect to their methodology and outcome assessment according to the concepts of evidence-based medicine (EBM). It was suggested that the essential methodological principles of EBM should be applied in clinical trials of TCM, including randomization, control and blindness. The sample size estimation, optimal parameter selection for outcome assessment, compliance and intention-to-treat analysis are all important aspects of randomized controlled trials. To bring the benefits of EBM into clinical trials will improve the quality of research in TCM and also promote international co-operation and communications. It is necessary to establish an assessment system of clinical outcome for TCM on the basis of EBM in order to evaluate the efficacy and safety of TCM objectively and scientifically.

In 21st century, clinical medicine moves toward a model of individualized health care. The development of the individualized model is based on the research findings of human genomics project including genotype and single nucleotide polymorphisms (SNPs), as well as the new health care model, that is, biological-psychological-social-environmental-spiritual. It reflects the idea of patient-centered care, and corresponds to the traditional practice of Chinese medicine, which addressed the individualized therapy on the basis of symptom pattern differentiation. However, the era of evidence-based medicine affords new meanings of individualized health care and promotes the research on the practice. The practice based on evidence would happen upon the integration of external research evidence, the expertise and experience of practitioners, and the value and preference of patients, so the decision of health care will be conscientious, explicit and judicious. This assay describes the meanings of individualized health care in different medical contexts, the characteristics of individualized practice in Chinese medicine, and proposals for further research in practice.

Cohort study is graded as level II in evidence grading system of evidence-based medicine, secondary to randomized controlled trial. It is one of the important evidence for the evaluation of health care interventions, and it has been applied recently in the evaluation of traditional medicine. The author of the article introduces the basic concept, principle, design, and implementation as well as relevant methodological issues when applied in traditional Chinese medicine.

Brain computer interface (BCI) is an interactive communication technology which can be achieved independent of human peripheral nerves and muscles.It provides a man-machine communication and control channel,without using muscular tissue,and makes the communication with outside world possible.This review describes the composition and working principle of the BCI system on the basis of the pervious research results.Then,it focuses on the comparative analysis of physiological parameter and the methods of feature extraction of visual evoked potential technology,spontaneous MU rhythm technology,slow cortical potential technology and so on.At last,the application of BCI technology and the prospect of its development are summarized.

The separate blood information database meets the need of recording information outside the blood station, and it can send the collected information to the database of No.1 Military Medical Project.

The article analyses the feasibility and necessary of hospital network establishment. Combined with the requirements and characteristics in hospital, the design strategies of network station is proposed along with the Topol. At last, this paper designs the safety plan from both software and hardware.

Objectives: To study the correlation between the dynamic expression of aquaporin-4 (AQP-4) around hematoma and the blood-brain barrier permeability after intracerebral hemorrhage in rats. Methods: Forty-two Sprague-Dawley rats were randomly allocated into sham-operation group, and groups of 6 hours, 12 hours, 1, 3, 7 and 14 days (n=6 in each group) after intracerebral hemorrhage. The intracerebral hemorrhage model in rats was established by injecting autologous arterial blood into caudate nucleus. Immunohistochemical method and Evans blue method were used respectively to detect the dynamic changes of AQP-4 around hematoma and the blood-brain barrier permeability in different time periods after intracerebral hemorrhage in rats. Results: (1) The expression of AQP-4 around hematoma increased gradually 12 hours after intracerebral hemorrhage, it increased significantly at day 1 and reached a maximum at day 3. It was slightly higher than normal level at day 7 and almost returned to normal at day 14 (P

Cohort study also named follow up study,has been used in clinical trials of traditional Chinese medicine(TCM),such as prognostic evaluation and therapeutic effect evaluation.Therefore follow up is an important step in a cohort study,and follow up quality will directly affect the statistical analysis and drawing a conclusion.This article introduced the aim,the content,the method and duration of follow up,we also discussed the relevant issues when conducting a follow up and the methods to deel with problems.We hope this article can be helpful to researchers of TCM.