0.001). The elevation of ?_2m appeared before the abnormality of BUN, blood Cr and urine protein in some patients. It is considered that ?_2m in serum and urine is a sensitive index of the early lesion of renal function in diabetics.

Plasma angiotensin II (PA II )and aldosterone (PA) were measured in 89 cases of diabetes mellitus by means of radioimmunoassay, compared with 40 normal controls. The results showed that PA II and PA increased significantly in diabetic patients without complications and with ketoacidosis (P

Objective To investigate the effect of gamma globulin combined with glucocorticoid pulse therapy in the treatment of children with refractory mycoplasma pneumonia in CRP and safety.Methods 46 cases of children with refractory mycoplasma pneumonia from February 2012 to February 2016 were selected and randomly divided into the control group and experimental group,23 cases in each group.On the basis of the regular treatment,the control group was given azithromycin,10mg/kg,qd,intravenous drip,on the basis of the control group treatment,the experimental group was treated with methylprednisolone 2mg/kg+human immunoglobulin 400mg/kg,qd,intravenous drip.The levels of serum C-reactive protein(CRP),white blood cell count(WBC),lymphocyte count(LC),therapeutic efficiency and safety were measured before and after treatment.Results After treatment,compared with the control group,the serum levels of CRP、WBC、LC were lower in the experimental group,the difference was statistically significant(P<0.05).The treatment efficiency of the experimental group(91.31％)was significantly higher than that of the control group(65.22％),the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion The gamma globulin combined with glucocorticoid pulse therapy can significantly reduce the serum levels of CRP,WBC and LC in children with refractory mycoplasma pneumonia,improve clinical efficacy and the safety were good.

Objective To observe the clinical effect of Sangao Decoction combined with Azithromycin in the treatment of mycoplasmal pneumonia in children.MethodsFrom August 2013 to August 2014, 76 children with mycoplasma pneumonia were enrolled in this study.The patients were randomly divided into observation group and control group.The control group was treated with azithromycin alone, and the observation group was given the treatment of Sanao Decoction on the basis of the control group.Comparison of the two groups of clinical efficacy, fever time, cough time, tonsil disappearance time, lung rales disappear time, length of stay and the incidence of adverse reactions.ResultsThe effective rate was 94.37% in the observation group and 76.32% in the control group, which was statistically significant (P<0.05).(2.45±0.90) d, duration of coughing (5.37±1.67) d, duration of disappearance of tonsil (6.23±2.47) d, disappearance of rales (7.18±1.58) d, duration of hospital stay (10.26±1.65) d were shorter than the control group, which was statistically significant (P<0.05).The incidence of adverse reactions was not statistically significant.ConclusionThe effect of Sangao Decoction combined with azithromycin in the treatment of mycoplasma pneumonia in children can significantly shorten the symptoms and signs of the patients, the time of disappearance of the signs and the length of hospital stay, promote the rapid recovery of children, high safety, and have good clinical application value.

Embarking from the people's livelihood science and technology, it is the important direction of new time health work to impel the medicine science and technology to serve the people's livelihood and to develop the people's livelihood. And it is also the request inevitably of the reform of health and medical community institutional. This article discussed the basic content of the people's livelihood science and technology, expounded that the medicine is the important component of the people's livelihood science and technology and has an important position in the development of the people's livelihood science and technology. At the same time, the article analyzed the problems which exist in the service of people's livelihood, of medicine science and technology in the current. And it was proposed that the policy should be reformed and innovated to speeds up the medical science and technology service of people's livelihood.

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Cryosurgery has already become one of the main means to treat advanced malignancies.Not only can the cryosurgery kill the tumor cells directly, it can make the human body to activate T cellular immunity as well.The purpose of this article is to summarize the achievements in the research related to the influence of cryosurgery on T cellular immunity in patients with malignancies and also to make a prospect of cryosurgery therapy in near future.

Varying doses of cobra crude venom were injected subcutaneously into rats.Formaking frozen and methylaldehyde fixed,paraffin embeded sections,tissues blockswere taken from the injected site muscles,hearts,livers,spleens,lungs,kidneysand diaphragms either immediately,or 6,12,24hrs after death.Tissue sectionswere stained with and ABC-immunocytochemical techniques.On HE stained sections,edema,heamorrhage,congestion were observed.Coludyswelling,necrosis,and breakdown of cells were seen in most of the organs.Nospecific morphological changes has been found.On the frozen sections of the musc-les taken from the injected site,kidneys and livers,the venom has been identifiedby ABC-immunocytochemical staining.Although as little as 2LD_(50) (2mg/kg) venomwas given,it could be demonstrated on the membrane of the muscle even 24 hrs afterdeath.In case of large amount of venom (11LD_(50) ) poisoning,the venom was alsofound in nucleus of liver cells and in the endothelial cells of capillaries of renalglomeruli.The pathogenesie of localization of snake venom in endothelial cells ofrenal glomerular capillaries was discussed,there is No report about the localizationof snake venom in nucleus of liver cells It is a very interesting phenomenonIt is usggested that the ABC-immunocytochemical stain is a sensitive and specificmethodforid entifying sanke venom in tissues of snake biting victims.

The pitiutary function tests in diabetes insipidus were compared by means of analyses of clinical data. It is considered that the water deprivation-ADH test is more reliable than the hypertonic saline test in differential diagnosis of complete diabetes insipidus from partial diabetes insipidus and central diabetes insipidus from nephrogenic diabetes insipidus. Some suggestions on the time of water deprivation test, the improvement of hypertonic saline solution test and diagnosis of partial nephrogenic diabetes insipidus were made in this paper.

Proton magnetic resonance spectroscopy is a new technique that can determine the concentrations of a few detectable metabolites altered in diseases.Proton magnetic resonance spectroscopy and spectroscopic imaging are of noninvasive and accuracy.This article focus on the role of proton MRS in preoperative diagnosis and differentiation,tumor grading,evaluation of the efficacy of brain tumor therapies and radiotherapy induced changes.