Objective To observe the clinical effect of ilaprazole in the treatment of peptic ulcer.Methods 100 patients with peptic ulcer were randomly divided into omeprazole group and ilaprazole group,50 cases in each group.The patients were given omeprazole or ilaprazole combined with amoxicillin and clarithromycin.The treatment effects and clinical symptom relief satisfaction rate were compared between the two groups.Results After treatment,the results under gastroscopy:in ilaprazole group,20 cases cured,16 cases healed,9 cases were effective and 5 cases were invalid.Those in omeprazole group were 14 cases,12 cases,12 cases,12 cases respectively.The differences between the two groups were statistically significant(U =3.78,P ＜ 0.05).The removal rate of Helicobacter pylori and clinical symptom relief satisfaction rate of ilaprazole group were significantly higher than those of the omeprazole group(x2 =3.84,4.57,P ＜ 0.05).Conclusion Ilaprazole can obtain good clinical effect in treatment of peptic ulcer,with high symptom relief satisfaction rate and clearance of Helicobacter pylori.

Objective To investigate the clinical efficacy of Fuzheng Huayu Capsule in the treatment of liver cirrhosis (decompensated) and its impact on quality of life in patients with TCM therapy research.Methods 160 cases of liver cirrhosis (decompensated) patients were chosen as research subjects.They were divided into experimental groupand control group according to random number table.Both groups used routine liver antiviral therapy,the experimental group was given Fuzhenghuayu tablets therapy,the control group only received conventional therapy.After 6 months of treatment,and treatment for the two groups of patients were evaluated quality of life conditions.Results Compared with before treatment,HA,LN,PC Ⅲ,Ⅳ-C of the indicators were significantly decreased,and the difference was statistically significant (t =10.89,15.88,10.42,12.38,4.41,9.27,4.97,6.55,all P ＜ 0.05).After the two groups of patients for the treatment of fibrotic indicators analysis found more significant decline in the observation group,the difference was statistically significant (t =5.32,3.88,5.25,5.01,all P ＜ 0.05).2 Compared with before treatment,ALT,AST levels of the two groups were significantly decreased,the difference had statistically significant (t =2.02,17.87,2.62,7.96,all P ＜0.05).for two groups of patients was compared with that total efficiency (87.50％ vs 66.25 ％),the difference was statistically significant (x2 =10.16,P ＜ 0.05).Compared with pre-treatment,two patients in the field of physiology,psychology field,the field of social relations,environmental areas and total score was significantly higher,the difference was statistically significant (t =13.94,12.37,11.12,10.71,16.45,8.60,6.54,8.35,4.86,8.04,all P ＜ 0.05) ; The two groups of patients after treatment compare the scores and scores found in the observation group was significantly more elevated,compared with the control group,the difference was statistically significant (t =4.97,3.81,4.98,2.56,5.05,all P ＜ 0.05).Conclusion In the treatment of hepatitis cirrhosis,Fuzheng Huayu Capsule can significantly improve the degree of liver fibrosis,improve the quality of life of patients and improve clinical outcomes.

Objective To investigate the influence of calcitriol in pancreatic islet β-cell function,blood glucose and blood lipids in patients with type 2 diabetes mellitus.Methods Ninety type 2 diabetes mellitus patients who had been treated with oral medications and whose treatment regimen was relatively stable were divided into calcitriol group (0.25 μ g/d) and control group (placebo) according to the treatment methods with 45 cases each,and all the patients were completed 12-week' clinical observation.Results After treatment compared with before treatment in calcitriol group,fasting plasma glucose (FPG),fasting insulin (FINS),homeostatic model assessment insulin resistance index (HOMA-IR),glycated hemoglobin (HbA1c),total cholesterol (TC),triglyceride (TG),and low density lipoprotein cholesterol (LDL-C) levels were significantly decreased,high density lipoprotein cholesterol (HDL-C) was significantly higher,and there were statistical differences (P ＜ 0.05).While there were no statistical differences in control group between before treatment and after treatment (P ＞ 0.05).Conclusion Calcitriol can improve glucose and lipid metabolism and pancreatic islet β-cell function in patients with type 2 diabetic mellitus and reduce insulin resistance.

Vitamin D and parathyroid hormone (PTH) are two classical hormones modulating calcium and phosphorus homeostasis.The rapid development of modern endocrinology has greatly expanded our understanding of these two hormones.The extra-skeleton effects of vitamin D/PTH are well documented,novel findings regarding to the embryonic and adult parathyroid development,and the changing clinical patterns in certain parathyroid-related disorders have been discovered.

Selenoprotein S1 (SEPS1) , a novel gene involved in the stress response of endoplasmic reticulum and inflammation control. Recent results provide a direct mechanistic link between SEPS1 and the production of inflammatory cytokines, suggesting SEPS1 may play a major role in the mediation of inflammation in IDDM and some other immunological disorders.

BACKGROUND: Health status of elderly people is an important problem concerned by the whole society. To find the way of preventing loss of functional status of daily life for elderly people is the key to generally improving the quality of life in elderly people.OBJECTIVE: To observe the main characteristics of function loss in healthy elderly people and analyze the influencing factors of the change of functional indexes in elderly people in normal functional status.DESIGN: Contrast observation; Logistic analysis.SETTING: Student's Office, Shangrao Normal College.PARTICIPANTS: All the data were from the sampling questionnaire survey on health status of 1 700 people including retired cadres and employees from 11 cities of Jiangxi province. The survey was conducted by Senile Physical Education Association of Jiangxi Province in January 2004.METHODS: The test was performed depending on 4 indexes in physical self-maintenance scale including dressing, taking food, bathing and toileting along with other indexes of shopping, calling, riding, going upstairs to the third floor, walking for 1 000 m, taking things by fingers and squatting & standing. These 11 indexes were used for evaluating the functional status of daily life in elderly people. According to international definition,people with difficulty in one or more indexes could be defined as ability loss of self-cave in daily life. The participants were demanded to give the score of difficulty in independently completing each activity including not difficult (1), somewhat difficult (2), very difficult (3), completely impossible (4). The total sum of 11 scores was defined as functional status index of daily life. Its value reflected the whole situation of functional status of daily life in elderly people. The higher the index was, the worse the functional status was. Comparison was conducted among groups of different gender and age, and Logistic regression analysis was used for evaluationand analysis.MAIN OUTCOME MEASURES: Evaluation of functional index, function loss rate of daily life, index in independent physical self-maintenance ability of daily life.RESULTS: ① Normal functional status of elderly people is various due to the different age, gender, constitution, marital status, living situation,employment history, economic status and education background etc. ② As far as function loss rate of daily life in healthy elderly people was concerned, male was higher than female, and people taking part-time jobs and rehired after retirement were higher than other retirees. When it came to loss rate of motor function of lower limbs, widowed people were higher than not widowed, and the higher the education, the better motor functional status of lower limbs the male had, while the situation was reversed for female.CONCLUSION: Loss rate of normal functional status of elderly people significantly decreases as their age increases, and it is relevant to the complexity and difficulty of activities of life. Normal functional status of elderly people is related to social support, economic status, psychological and mental status.

Type 1 diabetes includes two categories:autoimmune (type 1A) and idiopathic (type 1B)diabetes.Fulminant type 1 diabetes is a recently discovered subtype of type 1 diabetes with extremely rapid progression of hyperglycemia and ketoacidosis.The prevalence of fulminant type 1 diabetes among acute-onset type 1 diabetic patients is around 15%-20%.Class Ⅱ HLA genotype and virus infection may contribute to its development.The near-normal HbA_(1C) level despite a very high plasma glucose concentration in patients with ketoacidosis is the clue to diagnosis of fulminant type 1 diabetes.Treatment must be started immediately and aggressively when the diagnosis of fulminant type 1 diabetes is made or strongly suspected.

Objective To observe the curative effect of cervical rotating and pointing manipulation at supine position on Cervical Spondylosis (CS) based on X-ray localization diagnosis. Methods Combining the vertebra pathology shift on X-ray films with the 3-step-location diagnosis method to treat 448 CS patients by cervical rotating and pointing manipulation. Results The effective rate was 97.5%, and the improvement rate on X-ray films is 95.7%, the degree of manipulative reduction was in direct proportion to clinical effect. Conclusion Treating cervical spondylosis by Manipulative reduction based on X-ray localization diagnosis is very safe, accurate and good-effected.

Adrenocortical hormone (ACH) has been used in the treatment of the epilepsies,especially for epileptic encephalopathy,for over 70 years.ACH is clearly established as fast line treatment of infantile spasm and the Landau-Kleffner syndrome.This is typically as monotherapy in infantile spasm,but often in conjunction with anti-epileptic drugs in Landau-Kleffner syndrome,though the mechanism of ACH for epilepsies is not clear.However,in view of these potential adverse side effects,the use of ACH in the treatment of the epilepsies in children must be determined on a risk-benefit basis.

OBJECTIVE: To observe the efficacy of Yiqi runchang decoction in the treatment of pediatric constipation. METHODS: 300 young children in out-patient department were randomly divided into treatment group and control group(n=150). Treatment group were treated with Yiqi runchang decoction made by our hospital and control group were given Wangshi baochi pills. Usage and dosage of drug for children were determined based on the age of children. After 20 days of treatment, the clinical efficacy and symptoms of two groups were observed, such as abdominal pain, abdominal distension, anorexia, feeble and perspire. RESULTS: After two treatment courses, treatment group was superior to control group in clinical efficacy and improvement of symptom(P