Objective To investigate the clinical application value of procalcitonin(PCT)and C reactive protein(CRP)detection in the newborns with septicemia.Methods 50 newborns with septicemia in the hospital were enrolled as the observation group,and 50 healthy newborns at the same period were enrolled as the control group.Then the serum PCT and CRP levels and positive rates of two groups were detected and compared.The specificity,sensitivity,negative predictive values and positive predictive values of two indexes′single and combined application were analyzed,too.Results The serum PCT and CRP levels and positive rates of ob-servation group were all higher than those of control group,and the specificity and positive predictive values of two indexes′com-bined application were all higher than those of PCT and CRP single application(P <0.05).Conclusion The clinical application val-ues of PCT and CRP detection in the newborns with septicemia are high.The combined application is helpful for the early diagno-sis,it also can be as the curative effect of disease treatment effect.

BACKGROUND: Personality obstacle is a special type of psychopathy. Since it can reflect personal psychological traits, such as emotion, cognition, behavior mode and the ways one gets along with others, it may lead to meaningful functional impairments and psychological pains if they obviously deviate the normal range, resulting in functional malajustment to society, occupation, social ethics, rules and law. Therefore it deserves further investigation with respect to its criminological significance.OBJECTIVE: To investigate the influence of personality traits, age, educational degree, and marriage state before serving the sentence on criminal behavior of female offenders.DESIGN: A retrospective and control study based on patients.SETTING: Center of psychological sanitary in a hospital of a university.PARTICIPANTS: This study was carried out in the Psychological Sanitary Center of the First Affiliated Hospital of Chongqing Medical College between April 2004 and May 2004. Totally 223 female offenders who incarcerated in Chongqing Female prison were selected. Inclusion criteria: All participants aged from 18 to 60 years old and received above elementary school education. Exclusion criteria: Those who have definite body ailments or psychopaths. Finally totally 204 valid questionnaires were collected from female offenders who were then divided into violent criminal group( n = 120) and non-violent criminal group ( n = 84).METHODS: Totally 223 female offenders who incarcerated in Chongqing Female Prison were asked to fill personality diagnostic questionnaires (PDQ-R), Esonk' personality questionnaires(EPQ), and symptom self-rating chart(SCL-90). Finally totally 204 effective questionnaires were collected for statistical analysis with SAS software.MAIN OUTCOME MEASURES: Comparison of scores for three questionnaires between the two groups; relationship between general condition(age,educational degree and marriage state before incarceration) with the scores for the three questionnaires.RESULTS: The total score for PDQ-R was above 30 in both the two groups and without significant difference between them, ( P ＞ 0.05); the different results for EPQ between the two group was of statistical significance( P ＞ 0. 05); but the total scores for SCL-90 were markedly different between the two groups,( P ＜ 0.01 ); only "educational degree" was found positively correlated with "histrionic trait"; all items except "psychopathy" were close lined with the general state in EPQ questionnaires( P ＜ 0.05); "impulsion and the number of positive items" in SCL-90 were found related with the general condition( P＜ 0.05).CONCLUSION:All criminals have personality obstacle of different type and different degree, but the difference of personality traits between violent female offenders and non-violent female offenders was of no statistical significance.

A protein was isolated by DEAE-cellulose Chromatography and ultracentrifuge from the fruits of Momordica charantid L., and identified by chemical and polyacrylamide gel electrophoresis methods. The molecular weight was 34 000; isoelectric point pH 8.4,N-end amino acid was leucine.It was composed of 17 kinds of amino acids. The protein has been shown to have antifertility action in male rats.

Objective To perform radical abdominal trachelectomy on cases with cervical tumors for the removement of tumors and retain of fertility. Methods 4 cases with cervical tumors were performed radical abdominal trachelectomy in order to reserve the uterine function. Results Menstruation of all the 4 cases recovered after operation .Postoperative follow-ups revealed good results. Conclusion Radical abdominal trachelectomy can reserve the uterine function of patients with cervical tumors.However,further clinical observation needs to be performed to compare its survival rate with that of traditional modi operandi.

Objective To explore the clinical efficacy in the treatment of early diabetic nephropathy from ro-suvastatin combined with benazepril .Methods 107 patients of early diabetic nephropathy in our hospital were retro-spectively analyzed .On the basis of the conventional treatment of diabetes ,the control group were treated with benaze-pril;while the observation group were treated with rosuvastatin combined with benazepril .Before and after treatment , the improvement of the related indicators were observed , such as blood glucose ,lipids and renal function .The clinical efficacy were comprehensively evaluated .Results The level of the fasting blood glucose and 2-hour postprandial blood glucose of the observation group were lower than those of the control group , the difference was significant ( t=9.785,9.525,all P<0.05);the blood lipid levels such as TC ,TG and LDL-C in the observation group were signifi-cantly lower than those of the control group .But the levels of HDL-c was significantly increased , the difference was significant(t=9.938,10.283,10.475,9.782,allP<0.05);the indicators of renal function such as UAER ,Scr and BUN were significantly lower than those of the control group , the difference was significant ( t =9.938,12.341, 11.265,9.982,all P<0.05);The total effective rate of the observation group was 94.55%,significantly higher than the 76.92%of the control group, the difference was statistically significant (χ2 =10.120,P<0.05).Conclusion The effect of rosuvastatin combined with benazepril for the treatment of early diabetic nephropathy is very significant which is worthy applying in clinical practice .

BACKGROUND:Studies have shown that inflammatory cytokines may influence the prognosis after myocardial infarction, and play an important role in the process of cardiac remodeling. The non-hematopoietic effects of
erythropoietin have been confirmed:erythropoietin can reduce the inflammatory reaction through bending with
the erythropoietin on the surface of target cel membrane, thus decreasing the reperfusion injury after myocardial ischemia.
OBJECTIVE:To observe the effect of recombinant human erythropoietin on the inflammatory factor expression during cardiac remodeling in rats with acute myocardial infarction.
METHODS: Sprague Dawley rat models of acute myocardial infarction were established through the ligation of the left anterior descending coronary artery. The rats were divided into five groups:sham operation group was
injected with normal saline;operation control group was injected with normal saline after modeling;SB203580 group was injected with highly selective p38 MAPK inhibitor SB203580 after modeling;erythropoietin group was injected with
erythropoietin after modeling;the erythropoietin+SB203580 group was injected with erythropoietin+SB203580 mixed solution after modeling. The tail vein blood samples were col ected before modeling, 1 day, 1 week, 2 weeks and 4 weeks after modeling, and then enzyme-linked immunosorbent assay was used to detect the levels of interleukin-1β, interlrukin-6 and tumor necrosis factor-α.
RESULTS AND CONCLUSION:There were no significant differences in the levels of interleukin-1β, interlrukin-6 and
tumor necrosis factor-αbetween groups before modeling (P>0.05). There were no significant differences in the levels of interleukin-1β, interlrukin-6 and tumor necrosis factor-αbetween different time points in the sham operation group (P>0.05), and the levels were highest at 1 day after modeling in the other four groups, and then decreased at 4 weeks after modeling (P<0.05). After modeling, the level of serum cytokines in the operation control group were higher than those in the other four groups, while level of serum cytokines in the sham operation group was lower than that in the other four groups (P<0.05);among the three groups intervened with drugs, level of serum cytokines was lower in the
erythropoietin+SB203580 group (P<0.05), while there was no significant difference in the level of serum cytokines between erythropoietin group and SB203580 group (P>0.05). Recombinant human erythropoietin can inhibit the expressions of inflammatory factors (interleukin-1β, interlrukin-6 and the tumor necrosis factor-α) during cardiac
remodeling after rat acute myocardial infarction, and the mechanism of recombinant human erythropoietin for inhibiting the expressions of inflammatory factors may related with the transforming growth factorβ1-TAK1-p38 MAPK signal pathway.

Aqueous extract of Huaibaipi (Sophorae japonica)was shown to possess analgesic and antiinflammatory effects. It reduced rat paw edema,mice ear-swelling,and mice inflammatory peritoneal exudatinn induced by histamine, xylene,and acetic acid. It also prolong the tail-twisting time in rats stimulated by potassium ion permeation,and lengthened the leg-licking time in mice provoked by hotplate. Prolong administration can increase the weights of thymus and spleen in mice.

Objective: To investigate the clinical efficacy of remissive stage-reinforcing and acute stage-reducing acupuncture for treating apoplectic myospasm. Methods: Sixty patients with apoplectic hemiplegia were randomly divided into a treatment group of 30 cases and a control group of 30 cases. The treatment group was treated by remissive stage-reinforcing and acute stage-reducing acupuncture and the control group by modern rehabilitation training. Before and after treatment, the degree of spasm, the level of motor function and ability for daily life were evaluated by modified Ashwordth spasm grading, Brunnstrom grading and Barthel index now often used in the rehabilitation field. Results: Remissive stage-reinforcing and acute stage-reducingacupuncture was superior to modern rehabilitation training in relieving apoplectic myospasm. Conclusion: Remissive stage-reinforcing and acute stage-reducingacupuncture has a unique advantage in relieving spasm.

OBJECTIVE:To establish a method for simultaneous determination of gallic acid and ellagic acid in Xihe majun ointment. METHODS:HPLC method was performed on the column of X-Bridge C18 with mobile phase of methanol-acetoni-trile-0.2% Phosphoric acid solution (gradient elution) at a flow rate of 1.0 ml/min,detection wavelength was 254 nm,detection temperature was 30 ℃,and injection volume was 10 μl. RESULTS:The linear range was 0.132-0.792 μg for gallic acid (r=0.999 9) and 0.108 0-0.648 2 μg for ellagic acid (r=0.999 9);RSDs of precision,stability and reproducibility tests were lower than 3%;recoveries were 95.15%-99.69%(RSD=1.64%,n=9) and 97.24%-100.43%(RSD=1.24%,n=9). CONCLUSIONS:The method is simple,accurate and sensitive,and can be used for the content determination of gallic acid and ellagic acid in Xihe majun ointment.

OBJECTIVE: To evaluate the therapeutic efficacy and pharmacoeconomic results of 3 varieties antihistamines in the treatment of chronic idiopathic urticaria. METHODS: 96 patients with idiopathic urticaria were randomly divided into Group A, B and C, treated with mizolastine ,cetirizine and loratatine for 28 days, respectively. The therapeutic effects and recurrence within 7 days after drug withdrawl were observed, and the results were analyzed using cost-minimization analysis. RESULTS: The effective rates in Group A, B, and C were 96.7%, 94.1% and 93.8%, respectively. The recurrent rates within 7 days after discontinuation of the treatment were 40.0%, 35.3% and28.1%, respectively . The cost of drugs were 116.76 yuan, 45.64 yuan and 128.8 yuan, respectively. CONCLUSION: Cetirizine is the preferable treatment prescription for idiopathic urticaria