Curcumin can suppress the proliferation of esophageal cancer cells by inducing cell cycle arrest and blocking Notch signaling pathway,and can inhibit the invasiveness of esophageal cancer cells by inhibiting the nuclear factor-κB (NF-κB) signaling pathway and suppressing the formation of tumor blood vessels and inhibiting matrix metalloproteinase (MMP).Curcumin can also regulate apoptosis of esophageal cancer cells by changing the expression and localization of nucleophosmin.

Objective To investigate the gastric smooth muscle tumor in the stomach filling under Ultrasound imaging characteristics. Methods 38 cases confirmed by pathology in the stomach filling leiomyoma Ultrasound image data of the Ultrasound were retrospectively analyzed. Results Characterized by; submucosal circular, round,solid,hypoechoic,clear boundary,echo uniform tumor;a few blood flow within tumor,was particularly prevalent in the fundus,body;Size 0.5～5.0 cm,clear boundaries with the surrounding tissue. Filling the stomach Ultrasound technology to the diagnosis of gastric lipoma in line with the rate of 85. 2%. Conclusion Leiomyoma of the stomach in the stomach filling with characteristic under Ultrasound,stomach filling Ultrasound diagnosis of gastric smooth muscle tumors have a certain value.

Objective To investigate the effect of curcumin(Cur)on proliferation and apoptosis of human esophageal carcinoma drug-resistant cells Eca-109/VCR in vitro and in vivo. Methods The inhibitory effect of Cur on Eca-109/VCR was detected by CCK-8 method. The apoptosis rate of Eca-109/VCR cells after treatment with Cur was determined by flow cytometry. Eca-109/VCR xenografts were established in nude mice and inhibitory effect of Cur on xenografts was observed. HE staining was used to observe the morphological changes. Apoptosis was detect-ed by TUNEL. ELISA was used to measure Caspase-3,Caspase-8 and Caspase-9 expression in nude mice serum. Results Cur significantly inhibited the proliferation of Eca-109/VCR in a time and concentration-dependent man-ner and it could induce apoptosis of Eca-109/VCR. Cur significantly inhibited the growth of xenografts and a large number of necrosis existed in Cur group. Cur induced apoptosis in xenografts and the expression of Caspase-3,Cas-pase-8 and Caspase-9 in serum increased with the increase of Cur concentrations. Conclusion Cur could inhibit the growth of esophageal carcinoma xenografts in vitro and in vivo and its role might be up-regulating the expression of Caspase-3,Caspase-8 and Caspase-9 and associated with the apoptosis induction of drug-resistant esophageal carcinoma cells.

Objective To observe the clinical efficacy of valsartan combined with alprostadil in treatment of diabetic nephropathy. Methods Selected 84 cases of diabetic nephropathy patients in our hospital from January 2010 to January 2014. According to the different treatment methods they were divided into observation group and control group, each of 42 cases, two groups were treated with high quality low protein diabetic diet, and received the hypoglycemic (insulin), symptomatic treatment, anticoagulant buck. The control group was treated with alprostadil injection 10 μg with 20 mL of physiological saline bolus, once a day, for 12 weeks. On the basis of control group, the observation group was given valsartan 80 mg, 2 times daily, orally, 4 weeks for a course of treatment for 12 weeks. The changes of 24 hours urinary protein, creatinine, urea nitrogen before and after treatment and the effects of two groups after treatment were com-pared. Results The 24 hours urine protein, Cr, BUN levels before treatment had no significant difference between two groups of patients (P>0.05). After treatment, two groups of patients with Cr, BUN levels had no obvious changes with those before therapy, but of 24 hour urinary protein quantitative the observation group significantly decreased than be-fore treatment and control group after treatment, there was statistically significant difference between two groups (P<0.05). After treatment, the observation group's efficiency was 90.5%, control group was 73.8%, observation group's effi-ciency was significantly higher than the control group, there was significant difference between two groups (P<0.05). Throughout the course of treatment, the control group one case of transient palpitations, three cases of dizziness and headache, one case of cough. In the observation group two cases of cough, two cases of dizziness and headache, which were mild severity and did not affect the continued treatment. Conclusion The therapeutic effect of valsartan com-bined with alprostadil in treatment of diabetic nephropathy is accurate, can significantly improve renal function, is wor-thy of promotion and application.