The distribution of properdin factor B (Bf)allotypes and their gene frequencies in 81 patients with systemic lupus erythematosus (SLE) was investigated using high voltage agarose gel electrophoresis and subsequent immunofixation, in an attempt to define whether specific Bf allotypes were associated with the disease. An increase in gene frequency of Bf F in the patients with SLE (0.1914) was found in comparison with that in the controls (0.1159), P_(correct)

Disdvantages of chemotherapy in treating breast cancer were insensitivity or intolerance.There were different opinions on chemotherapy in treating negative axillary lymph notes or positive hormone receptors after breast cancer surgery.The advantages of TCM in treating breast cancer were:there were many Chinese medical oncologists who had rich clinical experiences in treating breast cancer before and during surgery,before and during chemotherapy,before and during radiotherapy and during the consolidation period;treatment according to syndrome differentiation with TCM for different stages of breast cancer had been gradually standardized;a well developed network of academic information provided a good platform for establishing the unified treatment protocols with TCM for different stages of breast cancer.It was indicated that large scale prospective clinical trials with TCM in the treatment of after-surgery breast cancer patients who had negative auxillary lymph notes and positive hormone receptors should be carried out.

Five min coronary artery occlusion followed by reperfusion in rats could produce arrhythmias which were rapid in onset & of short duration. The incidences of VT & VF being 100% & 72% respectively. Quinidine & dauricine reduced the incidence & severity of VT significantly; and abolished VF. Tetrandrine could reduce the incidence of VF significantly, but it had no significant effect on the incidence of VT.

Objectives To explore the pathological characteristics, treatment and prognosis of medulloblastoma (MB) in children. Methods Pathological characteristics, treatment outcomes and other clinical data were retrospectively analyzed in 60 children with MB. Results The MB in all 60 children were high-grade tumor. The pathological type was mainly classic (45 cases, 75.00%) and other subtypes were seen in 15 cases (25.00%). Forty-eight (80.00%) children had total resection by micro-surgery, 9 children (15.00%) subtotal resection, and 3 children (5.00%) partial resection. Twenty-seven children were treated by radiotherapy after surgery, 6 children were treated by chemotherapy after surgery, and 5 children were treated with radiotherapy combined chemotherapy after surgery. Thirty-eight cases were followed up. The 2-year survival and disease-free survival rates were 63.16%and 55.26%. The 5-year survival and disease-free survival rates were 26.32%and 18.42%. The children with des-moplastic/nodular type survived significantly longer than the children with large cell anaplastic. The children with total resection survived significantly longer than the children with partial resection. The children with radiotherapy or chemotherapy survived significantly longer than the children without chemotherapy (P<0.05). Conclusions MB in most of children is high-grade tu-mors and the prognosis is poor. The pathological type is related with prognosis. Microsurgical total resection is the first choice of treatment. Postoperative radiotherapy and chemotherapy can increase the survival rate.

Objective To investigate the value of ultrasound-guided Mammotome minimal invasive system in the treatment of breast fibroadenoma.MethodsFrom January 2007 to October 2008,266 benign breast lesions of 183 cases were treated by ultrasound-guided Mammotome minimal invasive system.The diameter of the masses ranged from 4 to 25 mm(≤ 10 mm in 73 cases,10-20 mm in 148,and ≥ 20 mm in 45).ResultsThe 266 lesions in the 183 patients were excised completely by using the Mammotome system.The excision was performed for a mean of 15 times in each case(ranged from 5 to 44 times) with an average operation time of 26 minutes(10 to 60 minutes).No complication was found after the surgery except slight subcutaneous ecchymosis in 2 cases.The length of the incisional scar,which was not apparent,ranged from 2.5 to 4 mm.The 183 cases were followed up by ultrasonography for 2 to 22 months(mean,12 months),during which their BI-RADS scales ranged from Ⅰ to Ⅱ,no local recurrence was found.ConclusionsUltrasound-guided Mammotome minimally invasive system is feasible for total resection of breast fibroadenoma with appropriate sizes.The technique leads to fewer complications and good cosmetic results.Further studies on the system are necessary for the treatment of multiple breast fibroadenomas.

ObjectiveTo investigate the curative effect of the treatment for the distal humeral shaft fracture with double steel plate internal fixation. Methods A total of 60 individuals who were humeral shaft fractures were included from March 2009 to April 2014 in the second people's hospital of Yunnan province. 28 of them were treated using double plate fixation(group A)and 32 of them were treated using single-plate treatment (group B). Blood loss, hospital stay, postoperative drainage, healing time and Mayo elbow performance score were compared between the two groups. Results(1)Blood loss, hospital stay and postoperative drainage showed no differences between two groups. However, the healing time between these two groups showed difference(P < 0.05).(2)MEPS score results showed a significantly difference in the excellent rate of patients between groups A and B(96.4% and 75%, respectively,P < 0.05). Conclusion The double plate fixation and single plate fixation for treatment of humeral shaft fracture showed no differences in operation time,blood loss,postoperative drainage and hospital stay. However,the double plate fixation showed a shorter healing time and better efficacy. Thus,the double plate fixation of humeral shaft fracture can contribute to obtain the rigid internal fixation,early functional exercise and better clinical efficacy.

Objective To analyse effect of dobutamine on C-reactive protein,D-dimer,BNP and blood gas analysis in children with neonatal pulmonary hypertension.Methods 46 patients who were diagnosed with neonatal pulmonary hypertension in our hospital were collected.All patients were randomly divided into experimental group and control group, 23 cases in each group.Control group was treated with sedation, maintenance of water electrolyte balance, blood pressure, anti-infection,experiment group was treated with dobutamine hydrochloride injection 5μg/(kg· min) intravenous infusion, continuous for 48 h on the basis of conventional therapy, after treatment,the levels of peripheral blood C-reactive protein, D-dimer and BNP and blood gas analysis effect were detected in all patients.Results Compared with control group post-treatment, the serum level CRP,D-dimer, BNP were lower in experimental group ( P <0.05 );the PaO2 and SpO2 levels were higher, the PAH level was lower in experimental group ( P <0.05 ) . Conclusion The dobutamine can significantly reduce the serum CRP, plasma D-dimer and BNP levels in children with neonatal pulmonary hypertension, reduce pulmonary hypertension.

Objective To observe the abnormity of heart function in rats with pressure overload-induced left ventricular hypertrophy and the changes of NCX,SERCA2a expression in myocardial tissues. Methods Cardiac hypertrophy was induced by clipping the abdominal aorta in rats. The cardiac hypertrophy was evaluated by Left ventricular weight index(LVWI,left ventricular weight/body weight). NCX, SERCA2a mRNA and protein expressions in left ventricular tissues were determined by half-quantitative RT-PCR and Western blot normalized to abundance of GAPDH mRNA and protein,respectively. Results LVSP and LVEDP were obviously enhanced(P

Objective: To study the characteristics of QT interval dynamicity in patients with heart failure (HF) and provide reference for predicting risk of sudden death in HF patients. Methods: A total of 80 inpatients with chronic HF from our department of cardiology were selected as HF group, and another 50 healthy volunteers were enrolled as healthy control group. All subjects received 24h ambulatory electrocardiography (ECG), surface ECG and echocardiography examination. Left ventricular ejection fraction (LVEF), left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), QT dispersion (QTd), index for heart rate variability-- standard deviation of normal to normal RR intervals calculated over the 24 h period (SDNN) and slope of QT/RR correlated linear were measured. Results: Compared with healthy control group, there were significant increase in LVESV [(34.0±8.3) ml vs. (90.4±15.4) ml], LVEDV [(86.0±32.2) ml vs. (150.3±30.4) ml], QTd [（35.6±8.5）ms vs.（46.6±10.4）ms], slopes of QTe /RR [(0.136±0.021) vs. (0.175±0.023)] and QTp/RR [(0.130±0.026) vs. (0.158± 0.033)], and significant decrease in LVEF [(60.6±8.4) % vs. (38.5±8.8) %], and SDNN [（140.3±53.3）ms vs.（100.4±40.3）ms] in HF group, P<0.01 all.. Conclusions: Instability of ventricular repolarization in patients with heart failure makes their QT/RR slope significantly higher than that of normal subjects.