Objective To investigate the clinical efficacy and safety of decompression in the treatment of large jaw cystic lesions.Methods 42 patients suffered from large jaw cystic lesions were randomly divided into two groups,21 patients in the control group performed the traditional curettage surgery;21 patients in the experiment group performed the decompression surgery.The intraoperative blood loss,operative time,the incidence rate of postoperative pain and postoperative infection,follow-up recurrence rate were compared between the two groups.Results The intraoperative blood loss,operative time,postoperative pain and postoperative infection rates of the experiment group were significantly better than the control group,the differences between two groups were significant(P ＜ 0.05).The recurrence rate of the control group and the experiment group was 24.0％,4.8％.The recurrence rate of the experiment group was significantly lower than the control group (P ＜ 0.05).Conclusion Compared to the traditional curettage surgery,decompression surgery can reduce blood loss,shorter operative time,reduce postoperative infection,reduce the risk of recurrence,then improve the clinical efficacy.