Abstract: Objective　To study the distribution and influencing factors of hospitalization costs of elderly patients with diabetes in Hainan Province, providing evidence for the relevant governmental departments in the formulation of prevention and treatment strategies for elderly diabetes. Methods Based on the homepage data of medical records of tertiary hospitals in Hainan Province in 2022, the hospitalization costs of elderly diabetes patients in Hainan Province were divided into five grades: lower, low, general, high, and higher. The hospitalization costs of 8 183 elderly diabetes patients in Hainan Province and their influencing factors were analyzed by using an ordered multicategory logistic regression model. Results The hospitalization costs of the elderly patients with diabetes in Hainan Province as a whole showed a right-skewed distribution but followed a nearly normal distribution within the range of 0-50 000 yuan, with a mean value of (10 446.32±10 228.36) yuan. The number of hospitalizations, medical institution visited, type of medical insurance, reimbursement ratio, household registration, gender, age, place of birth, marital status, and work unit were related factors affecting the level of hospitalization costs of elderly diabetes patients in Hainan Province (P<0.05). Compared to the group with ≥4 hospitalizations, the estimated coefficients for the group with 1 hospitalization was (β=-0.728, 95%CI: -0.852 to -0.603, P<0.001), for the group with 2 hospitalizations: (β=-0.359, 95%CI: -0.511 to -0.206, P<0.001), and for the group with 3 hospitalizations: (β=-0.314, 95%CI: -0.495 to -0.133, P<0.001), indicating that fewer hospitalizations significantly reduced hospitalization costs. Compared to those treated in medical institutions in other cities and counties, patients treated in Haikou City had (β=1.137, 95%CI: 1.028 to 1.247, P<0.001), and patients treated in Sanya City had (β=1.046, 95%CI: 0.916 to 1.175, P<0.001), showing that hospitalization costs for patients in Haikou and Sanya cities were significantly higher than those in other regions. Compared to those using commercial health insurance, patients using urban employee basic medical insurance had (β=-0.352, 95%CI: -0.531 to -0.173, P<0.001), those using urban resident basic medical insurance had (β=-0.384, 95%CI: -0.587 to -0.182, P<0.001), and those using the new rural cooperative medical insurance had (β=-0.545, 95%CI: -0.754 to -0.335, P<0.001), indicating that using social medical insurance significantly reduced hospitalization costs. Conclusions Diabetes patients consume a lot of medical and health resources, imposing a heavy economic burden on individuals, families, and society. Early prevention and treatment of diabetes should be implemented, with a focus on the health management of the elderly population to reduce the medical burden of diabetes in the future.

Objective To explore the influence of recombinant human brain natriuretic peptide(rhBNP)on the ventricular re-modeling and cardiac function of chronic heart failure rats.Methods Doxorubicin was injected for 2 weeks to obtain the chronic heart failure rats.Then different doses of rhBNP were injected for 4 weeks and objective indexes were recorded.Results The inde-xes were generally improved in the rats with rhBNP injection.The left ventricular absolute weight and left ventricular mass index obviously decreased in both middle and high dose group,but none difference was found between the two groups(P >0.05).The in-dexes of cardiac function of the high dose rhBNP group were improved most obviously,with the systolic pressure,diastolic pres-sure,left ventricular systolic pressure increasing and left ventricular end-diastolic pressure decreasing.right ventricular and diastolic stage decreased significenfly(P <0.05).The serum and myocardial levels of TNF-α/IL-10 generally decreased/increased in the rats after rhBNP treatment(P <0.05).Conclusion Long-term rhBNP treatment is likely to protect the ventricular remodeling and car-diac function and of chronic heart failure,which maybe relative to the positive regulation on inflammatory cytokine network of rhB-NP.

In order to investigate the neurotoxicity of lipopolysaccharide (LPS) on the dopaminergic neurons of substantia nigra and the pathogenesis of Parkinson disease, LPS was stereotaxically infused into substantia nigra (SN). At different dosages and different time points with 5 microg LPS, the damage of the dopaminergic neurons in SN was observed by using tyrosine-hydroxylase (TH) immunohistochemical staining. The results showed that 14 days after injection of 0.1 microg to 10 microg LPS into the rat SN, TH-positive (TH+) neurons in the SN were decreased by 5%, 15%, 20%, 45 %, 96% and 99% respectively. After injection of 5 microg LPS, as compared with the control groups, TH+ neurons began to decrease at 3rd day and obviously decrease at 14th day, only 5% of total cells, and almost disappeared 30 days later. The results suggested that LPS could induce the degeneration of dopaminergic neurons in the SN in a dose- and time-dependent manner.
Dopamine/metabolism ; Dose-Response Relationship, Drug ; Lipopolysaccharides/*toxicity ; *Nerve Degeneration ; Neurons/pathology ; Parkinson Disease, Secondary/*chemically induced ; Random Allocation ; Rats, Sprague-Dawley ; Substantia Nigra/*pathology

In order to investigate the neurotoxicity of lipopolysaccharide (LPS) on the dopaminergic neurons of substantia nigra and the pathogenesis of Parkinson disease, LPS was stereotaxically infused into substantia nigra (SN). At different dosages and different time points with 5 microg LPS, the damage of the dopaminergic neurons in SN was observed by using tyrosine-hydroxylase (TH) immunohistochemical staining. The results showed that 14 days after injection of 0.1 microg to 10 microg LPS into the rat SN, TH-positive (TH+) neurons in the SN were decreased by 5%, 15%, 20%, 45 %, 96% and 99% respectively. After injection of 5 microg LPS, as compared with the control groups, TH+ neurons began to decrease at 3rd day and obviously decrease at 14th day, only 5% of total cells, and almost disappeared 30 days later. The results suggested that LPS could induce the degeneration of dopaminergic neurons in the SN in a dose- and time-dependent manner.
Animals ; Dopamine ; metabolism ; Dose-Response Relationship, Drug ; Female ; Lipopolysaccharides ; toxicity ; Nerve Degeneration ; Neurons ; pathology ; Parkinson Disease, Secondary ; chemically induced ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Substantia Nigra ; pathology

OBJECTIVETo investigate the effects of modified vacuum sealing drainage (VSD) technique in treating refractory sinus in the lower leg.

METHODSFrom January 2010 to December 2011, 11 patients with refractory sinus in the lower leg, including 7 males and 4 females, with an average age of 34.5 years (ranged,23 to 56). These patients were treated with modified VSD technique after thorough cleaning sinus and continuous washing. After 14 to 21 days of treatment, removed VSD and re-debrided the sinus and sutured wound.

RESULTSInfections got control after operation, sinus in the lower leg healed. All patients were followed up from 6 to 14 months with an average of 10 months, no recidivations were found.

CONCLUSIONModified VSD technique is an effective method in the treatment of stubborn sinus in the lower leg.

Adult ; Drainage ; methods ; Female ; Fracture Fixation, Internal ; adverse effects ; Humans ; Leg Bones ; injuries ; surgery ; Male ; Middle Aged ; Postoperative Complications ; therapy ; Vacuum