Objective To provide an ideal tissular flap for the soft tissue defects of the oral commissure. Methods The observation and measurement of the source of blood supply and nerve innervation to the great/second toe web was carried out on 40 sides of adult specimens lower limbs perfused with red latex in artery. Results The first dorsal metatarsal artery which originated from the dorsal pedal artery was the chief artery to this region. Its external diameter at the beginning was (l. 6 ? 0. 3) mm and was (4. 6?0. 6) cm in length. Sensory nerve of the flap is deep peroneal nerve Conclusion The great/second toe web flap was an ideal tissue defects of the oral commissure.

OBJECTIVE: To explore the effect of positive-pressure ventilation on dust removal in whole lung lavage( WLL).METHODS: By random sample method,21 patients with stage Ⅱ or Ⅲ pneumoconiosis were chosen for different WLL.Using the patients' own left and right lung was used for matched control study. The positive pressure ventilation was performed at the end of the 3rd,6th,9th and 12 th lavage in treatment lung( treatment groups). The positive-pressure ventilation was not implemented at the end of the 3rd and 6th lavage in the contralateral lung( control groups) but implemented at the end of the 9th,11 th and 12 th lavage. The recovery of lavage fluid,dust and dust concentration drained from 4th to 9th lavage were compared in the two groups. RESULTS: There was no statistical difference in the recovery of the lavage fluid in the 4th to 9th lavage in the two groups( P > 0. 05). The amount of dust and the dust concentration in the fourth lavage drainage in the treatment group was higher than that in the control group( P < 0. 01). The amount of dust and the dust concentration in the 6th,8th and 9th lavage drainage in the treatment group was lower than that in control group( P < 0. 01). The amount of dust and the dust concentration in the 3rd positive pressure ventilation were higher than that in the 6th positive pressure ventilation in the treatment group( P < 0. 01). The total amount of dust in the treatment group was higher than that in the the control group( P < 0. 01). CONCLUSION: In whole lung lavage,the positive pressure ventilation can accelerate the discharge of dust in the lung of patients with pneumoconiosis.

Aromatic Chinese materia medica (CMM) have special aromatic odor, in which essential oils are widely present. It is reported that some essential oil components can significantly improve cardiovascular diseases by scavenging oxygen free radicals, relaxing blood vessels, improving lipid metabolism, reducing heart rate, and antiplatelet aggregation. Several mechanisms have been proposed for the role of essential oils in promoting cardiovascular health in aromatic CMM. The purpose of this review is to highlight and summarize the role of essential oils from aromatic CMM in reducing the risk of cardiovascular disease and their mechanisms. The research on essential oil components of aromatic CMM could discover new bioactive compounds and provide ideas for the development of new functional products for the treatment of cardiovascular diseases such as arterial hypertension, angina, heart failure, and myocardial infarction.

Objective To study the effect of different cutting time and drying methods on the index components of pharmacopeia in different fresh-cutting Aurantii Fructus, and investigate the difference of component and efficacy between the preferred fresh-cutting Aurantii Fructus and the traditional slices. Methods The HPLC system consisted of a Diamonsil C18 (250 mm × 4.6 mm, 5 μm) with acetonitrile/phosphoric acid water (20∶80, pH 3.0) as the mobile phase, the flow rate was 1.0 mL/min, column temperature was 30 ℃, detection wavelength was 283 nm, and the injection volume was 20 μL. The content of naringin and neohesperidin in fresh-cutting Aurantii Fructus with different processing methods was determined to optimize the cutting time and drying method. At the same time, the effects of sclices from fresh-cutting and traditional process on the small intestine propulsion rate, gastric emptying rate, gastrin, and hemorheology were determined. Results The content of naringin and neohesperidin of the fresh-cutting Aurantii Fructus that dried in sun was higher than that dried at 60 ℃ in oven at the corresponding days from the same origin, and the highest content was from fresh-cutting slices dried in sun for 3 d. There was no significant difference in the indexes of small intestine propulsion rate, gastric emptying rate, and gastrin between the preferred fresh-cuting Aurantii Fructus and the traditional ones, but the indexes of hemorheology showed significant difference (P < 0.05). Conclusion The preferred fresh-cutting Aurantii Fructus (processed by half cutting horizontally, drying for 3 d, and then cutting into thin slices and drying in the sun) showes no significant difference in gastrointestinal motility indexes when compared with the traditional ones.

OBJECTIVE: To study the endophytic fungi in the seeds of Gardenia from different regions, identy the strains carried by the seed surface and interior, and compare the treatment effects of different fungicides, to provide reference for the antibacterial treatment before gardenia seed sowing and fungal disease control. METHODS: Plate method was used for the surface and internal detection of Gardenia seeds from 15 countries in China, method of seed dressing was used for seed treatment and disinfection effects of 6 kinds of fungicides is done. RESULTS: Main flora in surface of the seed are genus Fusarium, Mucor, Penicillium, Aspergillus and Rhizopus, Penicillium and Aspergillus are the dominant species.There is no significant difference in this 5 species of the seeds from different places, but significant difference in isolation frequency.Load capacity of the spore range from (6.7±11.5) to (1333.3±230.1) per seed. There is significant difference in spore load from different places.Endophytic fungi inside the seeds are mainly Aspergillus, Penicillium, Mucor, Rhizopus and etc.There is significant difference in seeds of these fungi, it ranges from (1.7±2.9)% to (58.3±17.6)%. Carrier rate and species of fungal among different habitats are significantly different, discrete frequency of Aspergillus is the highest. CONCLUSION: The six antiseptics provided all have kill and inhibition to Gardenia seed fungus in some extent. Bactericidal effects of carbendazim fernasan and carbendazim are the poorest, and fernasan ziram and oxadixyl mancozeb and evil frost are the best, which can achieve above 95.0%. Suggestion is made to choose fernasan ziram and oxadixyl mancozeb as inhibiting fungus agents of Gardenia seed disinfection treatment.

Abstract The harm of head injury in skateboarding is more serious. The common injury cause is fall, collision, high speed impact. The primary types of injury include skull fracture, subdural hemorrhage, brain laceration contusion and concussion. Older children and adolescents, males, longboard, inappropriate sports venue are important risk factors for severe traumatic brain injury. Designing special skateboard parks and wearing protective equipment (helmets) can effectively reduce the incidence and severity of head injuries. The occurrence of injury can be reduced by adopting both legislation and education measures.

Cardiovascular diseases have become the most common and most prevalent chronic diseases in the elderly.Smoking, hyperlipidemia, diabetes and other high-risk factors participate in the occurrence and development of atherosclerosis by impairing the structure and function of the vascular wall, resulting in the occurrence of arterial stiffness.Pulse wave conduction velocity(PWV) is the rate at which a pulse wave travels from one specific location of the artery to another specific location along the wall of the artery.It is a simple, effective and repeatable noninvasive index for evaluating arterial elasticity and vascular function.PWV is closely related to cardiovascular disease.In recent years, the relationship between PWV and cardiovascular disease has been deeply studied.The relationship between PWV and coronary heart disease, hypertension, cardiac function, atrial fibrillation and pulmonary hypertension is described in this paper.

OBJECTIVE To establish the fingerprints of Ligusticum sinense from different habitats ，screen differential components and determine their contents. METHODS Using Z-ligustilide as reference ，HPLC fingerprints of 12 batches of L. sinense were established by using Similarity Evaluation System of Chromatographic Fingerprints of TCM （2012 edition）；common peaks were identified and their similarities were evaluated. Cluster analysis （CA），principal component analysis （PCA）and orthogonal partial least squares-discriminant analysis （OPLS-DA）were performed to screen differential components with variable importance in the projection （VIP）＞1 as standard ；meanwhile，the contents of above differential components were determined by the same HPLC method. RESULTS There were 17 common peaks in the fingerprints of 12 batches of L. sinense ，and their similarities ranged 0.989-1.000. A total of 9 common peaks were identified ，i.e. chlorogenic acid （peak 1），ferulic acid （peak 2）， senkyunolide Ⅰ（peak 7），coniferyl ferulate （peak 9），E-ligustilide（peak 13），senkyunolide A （peak 14），Z-ligustilide（peak 17）. CA results showed that 12 batches of L. sinense were divided into 3 categories，S1-S5（Wuning）were clustered into one category，S6-S8（Ruichang）were clustered into one category ，S9-S12（De’an）were clustered into one category ；the VIP values of peaks 2，13，14 and 17（corresponding to ferulic acid ，E-ligustilide，senkyunolide A ，and Z-ligustilide respectively ）were all greater than 1，respectively. In S 1-S5，S6-S8 and S 9-S12 samples，the contents of ferulic acid were 0.488-0.533，0.603-0.658 and 0.415-0.433 mg/g，respectively；senkyunolide A were 1.184-1.295，1.450-1.588 and 1.307-1.377 mg/g，respectively；E-ligustilide were 0.118-0.125，0.130-0.135 and 0.223-0.229 mg/g，respectively；Z-ligustilide were 7.200-7.681，8.076-8.643 and 4.508-4.996 mg/g， respectively；the differences between two groups were statisti-cally significant （P＜0.05）. CONCLUSIONS Established ARS-11）；fingerprint is simple and accurate ，and can be used for overall quality evaluation of L. sinense from different habitats by combining with multivariate statistical analysis. Ferulic acid ， senkyunolide A ，Z-ligustilide and E-ligustilide may be the differential components that affect the quality of L. sinense from different habitats ，the contents of the first 3 components in L. sinense from Ruichang are the highest ，and the content of E-ligustilide in samples from De’an is the highest.

Objective:To use autoregressive integrated moving average （ARIMA） model for predicting the mortality of cardiovascular diseases in residents in Yushui District， Jiangxi Province， and to provide basis for developing the prevention and control strategies as well as to promote the continuous optimization of chronic disease prevention and treatment demonstration area. Methods:Based on the cardiovascular death monitoring data of residents in Yushui District， Jiangxi Province from 2014 to 2018， Econometrics View 9.0 software was used to construct the ARIMA seasonal adjustment model to predict the monthly cardiovascular death in this area. Results:The monthly death rate of cardiovascular diseases in Yushui showed a long-term rising trend， with an apparent seasonal pattern （a peak of cardiovascular death from December to January each year）. After the original sequence was subjected to first-order difference and first-order seasonal difference， the difference sequence showed good stationarity （P<0.05）. All the theoretical models were listed and their model parameters were calculated respectively. After statistical test （P<0.05）， 7 alternative models for seasonal adjustment of ARIMA were selected. Among them， ARIMA（1，1，1）（1，1，1）₁₂ is the optimal model selected in this study （R²=0.749， Adjustment R²=0.724， AIC=8.454， SC=8.633， HQ=8.515）.And its residual sequence was tested by white noise test （P>0.05）， indicating that the prediction effect was good. Conclusion:ARIMA（1，1，1）（1，1，1） ₁₂ model can accurately simulate the long-term trend and seasonal pattern of cardiovascular disease death in Yushui， and make a scientific prediction of the trend and monthly distribution of cardiovascular disease death in the next three years.