1.The Effect of Bone Marrow Mononuclear Cells Transplantation on Myocardial Apoptosis after Acute Myocardial Infarction in Rats.
Ruicheng ZHANG ; Gang WU ; Jianfeng HOU ; Rujun ZHU ; Jianwei WANG ; Xia GAO ; Kai LIANG ; Baocai WANG ; Jiangjiang RU
Journal of Medical Research 2006;0(02):-
Objective To observe the effect of allogenic bone marrow mononuclear cells(BM-MNCs) transplantation on myocardial apoptosis after acute myocardial infarction(AMI) in rats.Methods 40 Wistar rats were randomly divided into control group(n=20) and transplantation group(n=20).Myocardium around the infarcted left ventricular area of the rats in transplantation group were injected with BM-MNCs suspension beneath the epicardium.Myocardium the area of control group was injected with culture solution.Results After 4 weeks of the operation,the myocardial apoptosis index,the TNF-? content and the PDCD5 mRNA of transplantation group were all notably less than those of control group(P
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