1.Research progress on long non-coding RNA in renal cell carcinoma
Anbang HE ; Haodong CHEN ; Zhaojie Lü ; Jiangeng YANG ; Hongbing MEI
China Oncology 2016;26(8):704-711
Long non-coding RNA (lncRNA) is a class of RNA molecules, transcripted by RNA polymeraseⅡ, which consists of more than 200 nucleotides and protein-coding function. Many studies have indicated that lncRNA plays an important role in epigenetics, transcription and post-translational processing. The abnormal expression of lncRNA significantly correlates with occurence,development, and metastasis of renal cell carcinoma (RCC) and prognosis of the patients with RCC. This paper summarizes the advances in the research on lncRNA in RCC to reveal the mechanisms of the disease at the molecular level, in order to provide new methods of prevention, diagnosis, treatment and prognostic assessment of RCC.
2.Study on the age composition of blood donors in some areas of China
Yuxiang CHEN ; Dongyan ZHAO ; Ling HOU ; Nan ZHAO ; Jing XU ; Xiaohua YUAN ; Xinyi TANG ; Dengping LEI ; Guiqi ZHAO ; Ying LI ; Yifei WANG ; Dan LIU ; Dong LI ; Can HUANG ; Lin WANG ; Yang ZHANG ; Xia DU ; Bin JU ; Shuangqin LI ; Shuanglin XUE ; Xiaojuan WU ; Jiangeng ZHANG ; Wusheng LI
Chinese Journal of Blood Transfusion 2022;35(4):368-371
【Objective】 To explore the recruitment and retention strategy of blood donors by investigating the age composition of blood donors in some areas of China, so as to promote blood donation and enhance clinical blood supply. 【Methods】 Through the working platform of Practice Comparison Working Group of China’s Mainland Blood Collection and Supply Institutions, the average age and age composition of blood donors from 22 blood centers were collected, and statistical analysis was conducted after eliminating invalid data. 【Results】 The median average age of blood donors during the survey year was 30.02.The median age in 2.89% of the blood centers was lower than 25. The average age of different genders was statistically significant only in 2018(P<0.05). Fot first-time blood donors, the median constituent ratio of donors <25 and ≥25 years old was 54.53% and 44.28%, with median retention rate at 10.30% and 9.61%, respectively. The median overall participation rate of blood donors was 2.7%, with median participation rate of blood donors <25 years old at 5.1%. 【Conclusion】 The recruitment and retention of blood donor is crucial to enhance clinical blood supply. Blood donors <25 years old, with a longer period for future donation, should be the main target of blood donation recruitment. Meanwhile, the revision of upper age limit for blood donation is another important initiative to grow the blood donor pool.