Objective To investigate CT and MRI findings of primary hepatic neuroendocrine tumor (PHNET) and the correlation with the pathology.Methods 14 patients with pathologically confirmed PHNET were analyzed retrospectively.All the patients underwent CT and 9 patients underwent MR.The CT and MRI findings were analyzed and the correlation with pathology was evaluated.Results Single lesion was found in 8 cases, and multiple nodular lesions in 5 cases, diffuse nodular lesions of the liver in 1 case.The lesions showed low density on CT images in all patients, and liquid-liquid level was visible in 1 lesion associated with internal bleeding.Contrast-enhanced CT in arterial-phase phase showed nodular or marginal ring enhancement in 13 cases, diffuse enhancement in 1 case, and in portal venous and delayed phases the enhancement of lesion subsequently decreased, compared with surrounding liver parenchyma.MRI showed hypointensity on T1WI and hyperintensity on T2WI, intralesional hemorrhage appeared as hyperintensity on T1WI and hypointensity on T2WI, and the enhancement pattern of MRI was similar to that of CT.With the increase of pathology grade,G1 presented as a single solid nodule,G2 as solid or cystic-solid nodules, and G3 as diffuse nodules or intrahepatic metastasis was found.The lesions showed hyperintensity on DWI.Conclusion CT and MRI can show characteristic appearances of PHNET and its certain histological characteristics.

[ ABSTRACT] AIM:To observed the correlation between Th17 cell level and the symptom severity and prognostic factors of chronic obstructive pulmonary disease ( COPD) , and to explore the clinical application value of Th17 cell level in assessing the prognosis of patients with COPD.METHODS:The patients with diagnosed COPD ( n=110) in our hospital during May 2013 to December 2014, and 40 healthy subjects were enrolled in the study.According to the Global Initiative for Chronic Obstructive Lung Disease ( GOLD) , the COPD patients were divided into group A ( low risk, less symptoms) , group B (low risk, more symptoms), group C (high risk, less symptoms) and group D (high risk, more symptoms), which were given inhaled corticosteroid/long-acting β2 agonist or corticosteroid/long-acting β2 agonist +long-acting anti-muscarinic agent treatment for 3 months.The proportion of Th17 cells, cytokines (IL-17 and IL-6), the COPD assessment test ( CAT) score, age, body mass index, pulmonary function and the times of acute exacerbation of COPD in previous 1 year were observed before and after treatment.The correlation analysis between the level of Th17 cells and other clinical characteristics was performed.RESULTS:Th17 cell, IL-17 and IL-6 levels in COPD group were significantly higher than those in control group (P<0.05).With the increase in the severity of COPD symptoms, Th17 cells, cytokines (IL-17 and IL-6) and CAT score in groups B and D were significantly higher than those in groups A and C (P<0.05).The univariate analysis showed that the levels of Th17 cells in groups B and D before treatment were positively correlated with the CAT score (P<0.05), which were negatively correlated with FEV1, FEV1%Pred, FVC and FVC%Pred.The levels of Th17 cells were not correlated with the CAT score, FEV1 , FEV1%Pred, FVC and FVC%Pred in groups A and C.The levels of Th17 cells after treatment were positively correlated with the CAT score, which were negatively correlated with FEV1 , FEV1%Pred, FVC and FVC%Pred (P<0.05).CONCLUSION:The peripheral Th17 cell level has a good correlation with IL-17, IL-6, CAT score and pulmonary function in COPD patients, suggesting a potential value to predict the symptom severity and prognosis of COPD.

0.05) none of the 39 cases of small cell type was in the AB blood group

Objective:To evaluate the clinical value of MR cholangiopancreatography(MRCP) as the only imaging procedure in diagnosing biliary complications after orthotopic liver transplantation(OLT).Methods: The MRCP results were analyzed in 54 consecutive patients presented with clinical or biochemical signs of biliary complications after receiving OLT,and were compared with the findings eventually confirmed by surgery,direct cholangiography,and clinical follow-up.Two different MRCP snapshot techniques were applied: thick-slab T_(2)-weighted sequences and multi-section thin-slab T_(2)-weighted sequences.Results: Surgery,direct cholangiography,and clinical follow-up confirmed that 36 patients had biliary complications.MRCP had a sensitivity of 100%(36/36) in diagnosing biliary complications after OLT,with a positive predictive value of 91.7%(33/36),a false-positive rate of 5.56%(2/36),and an overall diagnostic accuracy of 94.4%(51/54).MRCP as the only imaging procedure achieved a specific diagnosis in 96.3%(52/54) of the patients in the present study.Only 2 patients required additional endoscopic retrograde cholangiopancreatography and percutaneous transhepatic cholecystostomy.Direct cholangiography was required only as a therapeutic procedure in 25.9%(14/54) of the patients.Conclusion: MRCP is an effective imaging procedure in the assessment of biliary complications after OLT.Direct cholangiography is not needed for diagnosis but should be reserved as a therapeutic procedure.

Breast Neoplasms ; therapy ; China ; Female ; Humans

Antineoplastic Agents, Hormonal ; therapeutic use ; Breast Neoplasms ; chemistry ; therapy ; Carcinoma, Intraductal, Noninfiltrating ; chemistry ; therapy ; Female ; Humans ; Immunohistochemistry ; Medical Oncology ; standards ; Practice Guidelines as Topic ; Receptors, Estrogen ; analysis ; Receptors, Progesterone ; analysis ; Societies, Medical ; Tamoxifen ; therapeutic use ; United States

Objective To evaluate the effects of continuous application of niclosamide ethanolamine salt on Oncomelania hu-pensis snail control in a marshland,river and channel. Methods The Beiwei marshland in Houxiang Town,the Xiaoliang River in Lingkou Town and Laomiao channel in Yunyang Town in Danyang City were selected as study sites,and 4%niclosamide etha-nolamine salt and 26%niclosamide powder were used to kill the snails. Based on the historical records and field investigations, the effects of continuous application of niclosamide ethanolamine salt on snail control were evaluated. Results Compared with the first time of snail repetition,the snail areas decreased by 82.80%,63.14%and 70.00%in the Beiwei marshland,Xiaoliang River and Laomiao channel,respectively,in 2013. There was a positive correlation between the area and density of snails(r=0.931, 0.975 and 0.916,respectively;all P values < 0.05). The average densities of living snails decreased significantly by 92.34%, 87.91%and 97.66%,respectively. There was a negative correlation between the corrected mortality of snails and the average densi-ty of living snails in the following year,and a negative correlation between the reduction rate of living snail density and the average density of living snails in the following year. Conclusion Molluscicides plays an important role in compressing the snail area,re-ducing the snail density,and controlling the schistosomiasis transmission.

Objective To study a new method and technical specification for Oncomelania snail control in irrigation canals.Methods Four percent niclosamide ethanolamine salt dustable powder was dusted in a test canal three times continuously,and a control canal was set up at the same time.The molluscicidal frequency and effect of niclosamide ethanolamine salt powder was observed and the results,including the change of living snail frames,average density of living snails and mortality of snails,were analyzed.Results Between the third and fifteenth day after the first dusting in the test canal,the reduction rate of the density of snails was more than 90% and after the second and third dusting,the reduction rate was more than 99%.For the average rates of living snail frames and mortality of snails,there were significant differences between the first dusting and later two dustings,while there was no significant difference between the second dusting and the third dusting.On the thirtieth and ninetieth day after the third dusting,the effect of snail control was still satisfactory.There were significant differences between the test canal and control canal about all the observation indexes.Conclusion The application of 4% niclosamide ethanolamine salt dustable powder is efficient in the snail control in irrigation canals,and the suitable frequency of dusting is 2 or 3 times.

BACKGROUND:The traditional treatment for thoracolumbar vertebral fractures is posterior short-segment pedicle screw fixation. This method uses vertebral soft tissue stretch through distraction reduction mechanism, makes shift bone reset, and restores shape and height of vertebral body. Long-term folow-up found that part of cases experience complications such as vertebral height loss, loss of spinal correction of Cobb angle, the pedicle screw breakage and loosening. OBJECTIVE:To explore clinical effects of pedicle screw fixation combined with the implantation of artificial bone composite for the treatment of thoracolumbar fractures, and to compare with conventional pedicle screw. METHODS: A total of 80 patients with thoracolumbar fractures, who were treated in the Yantaishan Hospital from March 2011 to May 2014, were randomly divided into two groups. In the experimental group, patients received pedicle screw fixation combined with the implantation of artificial bone composite. In the control group, patients received routine pedicle fixation. Pain visual analog scale score was evaluated before treatment and at 6 months after treatment in patients of both groups, and easement of pain was evaluated after treatment. Vertebral body height (normal anterior flange height and up and down the front cone height and the ratio of the average multiplied by 100%) and sagittal Cobb angle (sagittal measurements of X-ray film) were measured in patients of both groups before treatment and at 1 and 12 months after treatment. According to conventional hierarchical evaluation criteria used al over the world, prognosis was assessed at 6 months after treatment, including basic cure, powerfuly, effectively, and invalid. RESULTS AND CONCLUSION: At 6 months after treatment, significant differences in pain visual analog scale scores were detected in the experimental group (2.4 points) and control group (3.7 points) (P < 0.05). No significant difference in height of the injured vertebra and Cobb angle was detected between the two groups before treatment (P> 0.05). The height of the injured vertebra and Cobb angle were better in the experimental group compared with the control group at 1 and 12 months after treatment (P < 0.05). Significant differences in treatment efficiency were detectable between the experimental group (90%) and the control group (73%) at 6 months after treatment (P < 0.05). These data indicate that pedicle screw fixation combined with the implantation of artificial bone composite in the treatment of thoracolumbar fractures can be used to fix fracture reduction, effectively restore height of injured vertebral body, prevent postoperative Cobb angle loss, and improve the treatment efficiency.

Objective To summarize the nursing experience of patients with artificial airway in intensive care unit(ICU).Methods 126 patients with artificial airway in ICU were collected,by using the digital table method,the patients were randomly divided into observation group(69 cases)and control group(57 cases).The control group was only given traditional nursing method,the observation group was given cluster nursing.The hospital time,indwelling time,unplanned extubation,ventilator associated pneumonia and the patients' satisfaction were assessed.Results After treatment,the hospital time,indwelling time,unplanned extubation,ventilator associated pneumonia of the observation group were(7.47±1.35)days,(4.16±0.89)days,four cases(5.80%),six cases(8.70%),respectively,which of the control group were(14.06±2.39)days,(9.64±2.34)days,nine cases(15.79%),fifteen cases(26.32%),respectivelywhich was lower than those of the control group [(14.06±2.39)days,(9.64±2.34)days,nine cases(15.79%),fifteen cases(26.32%)].The hospital time,indwelling time,the incidence rate of unplanned extubation and ventilator associated pneumonia of the observation group were shorter or lower than those of the control group(t=4.785,5.312,x2=4.991,5.471,all P<0.05).The satisfaction of the observation group was higher than that of the control group,the difference between the two groups was statistically significant(P<0.05).Conclusion Cluster nursing can significantly reduce the length of stay in hospital,extubation time,and reduce the incidence of accidental extubation and ventilator associated pneumonia.At the same time,psychological nursing can improve the satisfaction of patients and promote the recovery of patients.