Objective To investigate the clinical effect and the influence to coagulation factor of carboprost tromethamine on the treatment of the patients with postpartum hemorrhage. Methods 60 pregnant women with placenta previa complicated with postpartum hemorrhage from May 2016 to March 2017 were randomly divided into the control group (n=30) and the observation group (n=30). The control group were given oxytocin, the observation group were received carboprost tromethamine. Fibrinogen (FIB), prothrombin time (APTT), prothrombin time (PT) and platelet count before and after surgery in the two groups were analyzed by CA7000 automatic blood analyzer. The effect and coagulation indexes in the two groups were compared. Results The clinical curative rate in the observation group was 96.67% and 93.33% in the control group, the differences had no statistically significant. The amount of hemorrhage in postpartum 2h and 24h and the hemoglobin in postpartum 24h in the observation group were less than those in the control group (P<0.05); There was no significant difference about coagulation indexes between the 2 groups before treatment;The platelet count, PT and APTT levels in the observation group were lower than those in the control group, and the level of FIB was higher than that in the control group (P<0.05); The incidence of adverse reaction was 6.67% in the observation group and 10% in the control group, the difference was not statistically significant. Conclusion Choosing carboprost tromethamine to treat placenta prevail complicated with postpartum hemorrhage has a good curative effect, which is helpful to reduce the amount of postpartum hemorrhage and improve the coagulation indexes, so it is worth popularizing

Objective To explore the effect of different treatments for breast cancer patients.Methods The clinical date of 24 patients with breast cancer were retrospectively analyzed.According to treatment method,24 patients were divided into 2 groups,control group of 12 patients received,and vinorelbine plus cisplatin.Experimental group of 12 patients received gemcitabine plus cisplatin.Both groups were treated for 6 weeks,follow-up in JanuaryFebruary,after treatment the short-term efficacy and toxicity were observed.Results During follow-up compared betwween two groups,after 6 weeks of treatment in patients with overall response rate ( complete response + partial response) are better than 1 week after treatment,the difference was statistically significant( P ＜0.05 ) ;between the two groups compared after treatment,experimental group patients overall efficiency as better than the control group,but had no statistically significant difference( P ＞ 0.05 ).In the control group,Ⅲ + Ⅳ leukopenia,nausea,vomiting and phlebitis rate were relatively high than experimental group,experimental group Ⅲ +Ⅳ thrombocytopenia was higher than control group,the differences were statistically significant( P ＜0.05 ).Conclusion Early application of gemcitabine plus cisplatin in patients with breast cancer could significantly improve,the survival and prognosis,improve patients quality of life,and safe,it's worthy of promoting in clinic.

Medicine, Chinese Traditional ; Terminology as Topic ; Translations

Helicobacter pylori infection is a common gastrointestinal infection,which is a major cause of chronic gastritis,peptic ulcer,stomach cancer and gastric mucosa-associated lymphoid tissue lymphoma and other diseases.In recent years,many studies show that Helicobacter pylori infection is closely related with many diseases,which may cause the retardation of children development and affect blood lipids and glucose metabolism.Helicobacter pylori infection may also lead to chronic inflammatory process,results in a large number of cytokines and play an important role in artery atherosclerosis.This paper reviews on the correlation between Helicobacter pylori infection and metabolic diseases and its mechanism as well.

Mitogen-activated protein kinase (MAPK) signaling pathways are involved in multiple important cellular responses. To activate their downstream protein kinases by phosphorylation is a crucial manner for MAPK family members to fulfill their physiological functions. Downstream of MAPKs, there exist three structurally related MAPK-activated protein kinases (MAPKAPKs or MKs), i.e., MK2, MK3 and MK5. Once upon activated by MAPKs, MKs signal to different cellular targets, to regulate gene expression at the levels of transcription and translation, control cytoskeleton remodelling and cell cycle, and mediate cell migration and embryonic development. Recently, based on the gene knockout studies, the function divisions among different MK subfamily members are gradually clear, leading to tremendous advancements of our knowledge on MKs.

Intracoronary stent implantation is a safe and effective treatment for coronary artery disease.In-stent restenosis has been significantly reduced by utilization of drug eluting stents.This article reviews the results of long-term follow-up after intracoronary stent implantation and their implication.

0.05).Conclusion The intervertebral fusion cage of n-HA/PA66 has good biocompatibility and osteo-conductibility.It may be the ideal interbody fusion cage.

The flow distribution of leukocytes in the microvasculature of rat skeletal muscle during hemorrhagic shock was measured by Microcirculation Image Multiple Parameters Computer Analysis System (MIMPCAS). It was found that the change of leukocyte flow distribution had taken place in V3 during hemorrhagic shock as follows: central axial-flowing leukocytes moved slowly, marginated to the vessel wall then started to roll along the wall, and stuck to the endothelium at last. During transfusion blood flow became faster, sticking leukocytes were rushed out to be rolling along the vessel wall and accelerated to enter the central stream. Total leukocyte -endothelium contact time (TLECT), which is a quantitative index for leukocyte endothelium interaction, is calculated, and it was found that TLECT was prolonged in shock state. The results show that it is not enough to increase blood pressure and shear stress to liberate sticking leukocytes, and it is necessary to search for a new approach to decrease the adhesive force between leukocyte and endothelium. Polygonum cuspidatum may not only increase wall shear rate but also decrease the adhesive force.

Sepsis is systemic inflammatory response syndrome(SIRS)associated with the presence of pathogenic microorganisms or their toxin.Lipopolysaccharide(LPS)is an important component of the outer membrane of Gram negative bacteria and has a pivotal role in inducing Gram negative sepsis.Macrophages play an essential role in infection and inflammation.Specific recognition of LPS is of particular importance in the defense system and pattern recognition receptors(PRR)have been considered to be important in initial steps for cellular recognition of LPS and consequence initiation of LPS responses.In the past few years,intense research in the fields of PRR and their recognition mechanism has been achieved.In this review,we attempt to expound recent research advances of macrophage PRRs for LPS recognition and their mechanism.

There are some characteristics in the teaching of amateurish adult medical students.As a bridge connecting basic medicine and clinical medicine,pathophysiology is very important in medical education.Aiming at the specialties of amateurish adult medical students,it has very realistic significance for us to explore and reform the teaching methods of pathophysiology,in order to improve the teaching quality and effect.