Objective To investigate the association between diabetes and pancreatic cancer to provide the basis for the early di‐agnosis and prevention of pancreatic cancer .Methods By formulating the retrieval stategy ,the databases of PubMed ,EMbase ,Ov‐id 、EBSCO ,CNKI and CBMdisc ,VIP ,Wanfang/database etc .were retrieve by computer from their establishment to July of 2013 .At the same time ,the relevant literature references were also retrieved .All case‐control studies(CCS) on the association between diabe‐tes and pancreatic cancer were included and their quality was assessed .The meta analysis was conducted by using Review Manager 5 .0 software .Results A total of 21 CSC were included ,finally 18 case‐control studies met the inclusion criteria for conducting meta analysis ,including 6 184 cases in the pancreatic cancer group and 10 296 cases in the control group .The meta analysis on the pan‐creatic cancer group and the control group showed that the result of heterogeneity test from all research data was I2 = 74% ,χ2 =65 .38 ,P< 0 .01 ,the random effects model was adopted ,the pooled odds ratio(OR) was 3 .60 and 95% confidence interval(95% CI) was 3 .28 - 3 .94 ,the difference showed the statistic significance(P< 0 .05) ,which indicating that the risk suffering diabetes in the patients with pancreatic cancer was 3 .6 times of the normal population .Conclusion Diabetes is associated with pancreatic cancer and diabetes may be an early clinical manifestation of pancreatic cancer .

Objective To develop a method for determination of magnolin in Bimingan Pellets. Methods HPLC was adopted for determination by using Agilent Eclipse XDB-C18 column (4.6 mm×150 mm, 5 μm), acetonitrile-water(40∶60) as the mobile phase. The detection wavelength was 278 nm. Results The method was linear in the range of 0.117~2.340 μg for the injection volume of magnolin(r=0.999 94), and the average recovery was 99.4%, RSD=1.9%. Conclusion The method was simple, accurate, reliable and reproducible for the quality control of Bimingan Pellets.

Objective To observe the therapeutic effect of hydrogel dressing for alprostadil-induced phlebitis. Methods Forty-three patients with alprostadil-induced phlebitis were randomly divided into two groups:the treatment group (n= 22),in which hydrogel dressing was applied to affected area,and control group(n = 21),in which mucopolysaccharide polysulfate cream was used to coat the surface of the skin. The curative effects were observed and compared between the two groups. Results The therapy effect on day 7 was superior to that on day 3 in both groups.The curative rate was 86.36% in the treatment group and 47.62% in the control group(P<0.05). Conclusion Hydrogel dressing can effectively treat alprostadil-induced by phlebitis.

OBJECTIVE To investigate the status of the sharp injuries among medical workers in operating department and explore the countermeasures for the occupational protection.METHODS The status of the sharp injuries was investigated retrospectively from Jul 2006 to Jun 2007 used a self-designed questionnaire among 255 medical workers in three grade 2A hospitals in Tongcheng city.RESULTS Among the medical workers 63.14% suffered sharp injuries.Furthermore,the proportion of sharp injuries among doctors,nurses and nurse students were 46.67%,80.00% and 92.73%,and the sharp injuries rate was closely associated with the working years.The type of sharp injuries was closely associated with occupation.The proportion of reporting sharp injuries among doctors,nurses and nurse students was 38.57%,87.50% and 3.92%,respectively.The proportion of taking on gloves among doctors,nurses and nurse students was 88.0%,80.0% and 16.37% when they worked in contact with blood or body liquid.CONCLUSIONS The medical workers meet the danger of sharp injury.Nurse students and new medical workers have high incidence of the sharp injury,so they are high-risk subjects who should enhance their safeguard procedures.Thus,perfecting the operating protocols and standardizing the managements of occupational prevention and protection could reduce the sharp injuries rate.

Objective To study the influence of evidence-based health education in improving the ability of daily life and nursing satisfaction of patients.Methods A total of 80 schizophrenic patients were randomly divided into a control group (40 persons) and an experimental group (40 persons).The health education of routine ways was adopted on the control group.As for the experimental group,we posed questions,collected related literature and evidence through evidence-based support,set the health education based on the actual situation for individual and adjusted flexibly according to the affect of the health education during practice process.Two groups of patients were assessed by daily activity scale,positive and negative symptom scale weekly.We use questionnaire to compare with the satisfaction of two groups for patients when they left hospitals,including the disease-related knowledge,the satisfaction of the ways of the health education,the satisfaction of nurses.Using SPSS 18.0,the data between two groups were compared by t test,or Z test,or chi square test.Results After the implementation of evidence-based health education,the experimental group started at the second week,the PANSS scale score was lower than the control group,and the difference was statistically significant (P＜0.05).The score of experimental group'ADL scale compared with control group reached normal level in the third week and had statistic significance,P＜0.05.The questionnaire results showed that the average score of disease related knowledge and the average score of health education methods were higher in the experimental group than in the control group,and the difference was statistically significant (P＜0.05).In the evaluation of the most satisfactory nurses,patients' satisfaction in experimental group was higher than the control group,and the difference was statistically significant (x2=16.56,P=0.000).Conclusion The implementation of evidence-based health education for patients with schizophrenia can effectively improve their daily living ability,improve their mastery of disease-related knowledge and satisfaction with nursing.

The review summarized the diagnostic strategy of ischemic cerebrovascular diseases and introduced some progress in clinic.As ischemic cerebrovascular diseases were highly heterogeneous,the review analyzed their characteristics step by step.Through the primary diagnosis,etiological diagnosis,evaluation of risk factors and factor analysis of the whole body,the review describe the diagnostic program of the diseases and provide suggestion about the individually therapy and prevention.

Objective To observe the targeting effect of curcumin gelatin microsphere in rats in vivo. Methods Injections of curcumin gelatin microsphere and curcumin were injected via tail vein, respectively. HPLC was used to determine the content of curcumin in different organs. The pharmacokinetic parameters were calculated on the basis of compartment models by using DAS 2. 0 program. Targeting efficiency was used to evaluate tissue distribution of curcumin. Results Targeting efficiency of curcumin gelatin microsphere in heart, liver, spleen, lung and kidney was 0. 875, 0. 121, 1. 182, 5. 834 and 0. 896, respectively. Conclusion Curcumine gelatin microspheres can improve lung-targeting efficiency, and benefit for study on lung targeting therapeutic effect.

Objective To screen extraction process for Rosae Laevigatae Fructus.Methods With the content of total saponins and total phenolic acids from Rosae Laevigatae Fructus as the evaluation indexes, ethanol concentration, extraction time, solid-liquid ratio and extraction times as investigation factors, the test data were analyzed by Design-Expert8.0.5 software, and a multiple quadratic regression equation was set up to screen extraction process parameters of Rosae Laevigatae Fructus.Results The best extraction process parameters of Rosae Laevigatae Fructus were as follows:ethanol concentration was 62.79%;solid-liquid ratio was 13.12:1;the extraction time was 137.93 min;extraction times were 1.85 times. Considering the convenience for actual operation and the practicability of industrial production, the extraction process parameters should be ethanol concentration of 60%, revised solid-liquid ratio of 13:1, 2 hours' extracting time, and 2 extraction times.Conclusion Final selected parameters provide the basis for the extraction process of Rosae Laevigatae Fructus.

Objective To investigate the feasibility with low dose contrast agent in patients undergoing peripheral magnetic resonance angiography with high spatial resolution at open-bore 3 T scanner. Methods Images of MRA were assessed separately by two radiologists. And the images of DSA were assessed by one radiologist. The degree of the two interobservers' consensus for detection of arterial stenosis was determined by calculating the Kappa coef-ficient. Spearman rank correlation coefficient was used for revealing the relationship between contrast-enhanced MR angiography and DSA,in terms of categories of stenosis. Results For the degree of vessel stenosis, Cohen' s statis-tics revealed excellent agreement between the two observers. There was a significant correlation between DSA and MRA(P<0. 05). Conclusion At this open-bore 3 T scanner, high spatial resolution peripheral magnetic reso-nance angiography is achieved with low dose contrast agent.

Objective To study whether the correlation exists between 6 kinds of autoimmune antibodies and female infertility . Methods The protein microarray technique was adopted to detect serum antibodies of anti-sperm antibodies(ASAb) ,anti-endome-trial(AEmAb) ,anti-zona pellucida(AZpAb) ,anti-ovarian(AVoAb) ,anti-hCG(AhCG Ab) and anti-trophoblastic(ATAb) in 140 ca-ses of female infertility and the correlation between these 6 kinds of antibody with female infertility was evaluated .Results Com-pared with the control group ,except AvoAb ,the positive rates of other 5 kinds of antibody had statistically significant differences (P<0 .05) .In the infertility group ,the positive rate of the combined detection of these 6 kinds of autoimmune antibody had statisti-cal difference compared with that of single item detection (P<0 .05) .The positive rate of these 6 kinds of autoimmune antibody in the primary infertility group and the secondary infertility group had statistical difference compared with the control group ;the posi-tive rate of these 6 kinds of autoimmune antibody in the secondary infertility caused by different etiologies had no statistical differ-ence (P>0 .05) .The positive rate of ANA had no statistical difference between the infertility group and the control group (P>0 .05) ,but the titers of ANA in the experimenter were ≥1∶100(6/7) and most of karyotypes were nuclear coarse (5/7) ,which was differed from the low positive titer in the control group .The positive rate of ANA had statistical difference between the infertility related antibody positive and the infertility related antibody negative in the infertility patients .Conclusion ASAb ,AZpAb AEmAb , AhCGAb and ATAb are related with female sterility .The combined detection of these 6 kinds of antibody can significantly increase the detection sensitivity .