Objective To explore the clinical application of two endometrial mechanical stimulation methods in patients with repeated implantation failure (RIF) in frozen-thawed embryo transfer (FET) cycle. Methods A total of 127 women with RIF who planned to perform FET again were included. They were separated into 3 groups: Group A (45 cases) with endometrial scratching and group B (42 cycles) with endometrial sucking within menstrual period in FET cycle, while in control group C (40 cases), no endometrial mechanical stimulation was performed. The outcomes of pregnancy were compared. Results The endometrial types of endometrial scratching group were mainly type A. The embryo implantation rate and clinical pregnancy rate in group A (27.27%, 46.67%) were significantly higher than those in group B (12.75 %, 21.43%) and group C (11.46%, 20.0%) (P <0.05). Conclusion The endometrial mechanical stimulation can improve the endometrial receptivity, compare with endometrial sucking, endometrial scratching can improve the clinical pregnancy rate of RIF patients more obviously.

Objective To explore the research status and hot highlights in the field of Alzheimer's disease nursing,and provide reference and direction for future research.Methods The high-level articles on Alzheimer's disease nursing during 2012 to 2022 were collected from Web of Science core database,were analyzed and visualized by the CiteSpace 5.8.R3C software.Re-sults 956 articles were included in the Web of Science core database.The demand and focus on AD nursing research increased year by year.United States America had the largest number of articles(175 articles),followed by France(43 articles)and Chi-na(31 articles).Minnesota University and Harvard Medical School had the largest number of articles(11 articles).The authors'analysis shows that BRUNO VELLAS,an academician of the French Academy of Sciences,had the largest number of articles.Keyword co-occurrence analysis shows that the research in the past decade mainly focuses on"nursing home","people"and"quality of life","long-term care"and"exercise therapy"may become the key research directions in the future.Conclusion Domestic scholars should improve the social security system of long-term care,promote"people-oriented"humanistic nursing services and develop appropriate sports training programs in the future.