1.Update of researches on acute lung injury in thoracic surgical procedures
Journal of Medical Postgraduates 2004;0(02):-
With the development of the thoracic surgery, clinicians are paying more and more attention to acute lung injury (ALI) following thoracic surgical procedures. Many factors may cause ALI during the operation. This review updates recent researches on the pathogenesis and treatment strategies of the ALI in thoracic surgical procedures.
2.Study on correlation between TSH decrease and post-stroke depression
Jinsong CHEN ; Guixi LIN ; Jian YAO
Chongqing Medicine 2015;(15):2040-2041,2044
Objective To study the correlation between TSH decrease and post‐stroke depression .Methods 101 patients with acute brain infarction in our hospital from October 2012 to July 2014 were collected as the study subjects and divided into the TSH decrease group and the TSH normal group according to whether serum TSH levels less than 0 .27 uIU/mL .The two groups were evaluated on admission by the National Institute of Health Stroke Scale (NIHSS) ,at 3 months after discharge by modifies Rankin′s Scale(mRS)and the Hamilton Depression Scale(HAMD)respectively .Results The HAMD scores at 3 months in the TSH decrease group were significantly higher than those in the TSH normal group (16 .04 ± 3 .34 vs .14 .03 ± 3 .47 ,P=0 .000)and the mRS scores NIHSS score were significantly higher than those in the TSH normal (3 .2 ± 1 .1 vs .2 .1 ± 1 .5 ,P<0 .05)) .The ra‐tio of poor prognosis in the TSH decrease group was higher than that in the TSH normal group (89 .3% vs .38 .4% ,P<0 .05) ,in‐dicating that the prognosis in the TSH decrease group was poor .Conclusion The correlation could exist between the decrease of TSH level with post‐stroke depression .In acute brain infarction ,the patient with low TSH level could have the poor prognosis .
3.Nutritional evaluation of porphyra haitanensis
Bilian CHEN ; Yuexin LIN ; Jian HUANG
Chinese Journal of Marine Drugs 1994;0(02):-
The main nutrient compositions of dry Porphyra haitanensis cultivated in Lianjiang,Fujian Province were analyzed: the total amino acids content was 35.48%. The scores of amino acids were 71 for Ile and 80 for Leu. Crude fatty acids was as low as 0. 5%,in which EPA took 24.8%. Minerals in Porphyra haitanensis were abundant. The content of Ca、Fe、 Zn、Mg were 3. 63、0. 56、0. 095 and 3. 29mg?g~-1. The results indicated that Porphyra haitanensis is a kind of health food with high nutrition.
4.The correlation of serum creatine kinaseisoenzyme-MB and the prognosis of patients with acute coronary syndrome
Ling CHEN ; Jian ZENG ; Xueying LIN
Chinese Journal of Postgraduates of Medicine 2009;32(16):22-24
Objective To investigate the correlation of serum ereatine kinase iseenzyme-MB (CK-MB) and recent cardiac events(30 days, 180 days) and late cardiac events (360 days) in patients with acute coronary syndrome (ACS). Methods Serum creatine kinase (CK) and CK-MB in 168 patients with ACS were measured, and these patients were divided into four groups according to the levels of CK and CK-MB. The occurrence of cardiac events analysis of CK and CK-MB was followed up for 30, 180 and 360 days and the relationship between the occurrence of cardiac events and the levels of CK and CK-MB were studied. Results There was statistical correlation between increased CK-MB and abnormal ECG Q wave, ST segment change (P< 0.05), 168 patients had followed up 30, 180 and 360 days, in which cardiac events happened in 57 common patients (64 examples), 27 examples (16.1%) happened in the recent cardiac event, and 37 examples(22.0%) happened in the late cardiac event. The cardiac event and CK-MB elevation had statistical correlation (P<0.05). Conclusion ACS patients with increased CK-MB levels prompt a poor prognosis, and could be an independent indicator of recent and late cardiac events in patients with ACS.
5.Distribution of Cadmium and Lead in Soil and Rice Along Road Polluted by Traffic Exhaust
Jian LIN ; Zixian DU ; Jianan CHEN
Journal of Environment and Health 1992;0(02):-
coarse polished rice for lead respectively. Positive correlations were observed in contents of cadmium and lead between soil and rice (r=0.942~0.994, P
6.Distribution of pegylated liposmal doxorubicin in animal model of tongue cancer
Shaowei CHEN ; Jian PAN ; Lin ZHOU
Journal of Practical Stomatology 2001;0(01):-
objective: To observe the distribution of pegylated liposmal doxorubicin(PLD) in animal model of tongue cancer. Methods: Tongue cancer model was established in 40 golden hamster, PLD or free doxorubicin at the dose of 9 mg/kg was injected perifocally into each of 20 mice, the concentration of the drugs in lypmph node and blood was measured with HPLC. Results: After injection of free ADM peak concerntration in blood was acheived in 3 h and in lymph nodes in 1 h, while after injection of PLD, that was in 16 and 6 h respectively. The concertration of PLD was heigher than that of ADM in both blood and lymph node from 16 or 6 h till 216 h after injetion.Conclusion: PLD can be regarded as valuable drug delivery system in the treatment of oral cancer.
7.Extraction of Essential Oil from Asarum forbesii Maxim. by Supercritical Fluid Extraction(SFE)
Jian CHEN ; Yi PAN ; Qingsheng LIN
China Pharmacy 2007;0(36):-
OBJECTIVE:To facilitate the application of Asarum forbesii Maxim. in the fields of medicine and fine chemicals. METHODS:The essential oil was extracted from Asarum forbesii Maxim. by supercritical fluid extraction (SFE), and the chemical constituents of essential oil were analyzed by GC-MS. RESULTS:22 constituents were identified, dominating the list were 1,2-Benzenedicarboxylic acid (mass fraction:20.47%), Eugenol methyl ether (15.37%),(Z)-9-Oleic acid(13.21%), 9,12-Octadecadienoic acid (Z, Z) (12.53%),Elemicin (11.05%), n-Hexadecanoic acid (7.59), Octadecanoic acid (4.36%). CONCLUSION:The method used on essential oil extraction serves as references for the further exploitation and utilization of Asarum forbesii Maxim..
8.Investigation of Dissolution of DEHP in Packaged Infusion Sets of Paclitaxel Injection
Enjuan ZHANG ; Lin CHEN ; Jian CAO
China Pharmacy 2001;0(09):-
OBJECTIVE:To investigate the dissolution of DEHP in PVC infusion set and the packaged infusion sets of the Paclitaxel injection so as to evaluate the safety of clinical infusion sets for paclitaxel.METHODS:The packaged infusion sets of Paclitaxel injection were collected from 9 Three-A grade hospitals in Chongqing.Paclitaxel injections were prepared as per actual concentration needed by the clinic and dripped through eight different infusion sets(in which 7 were packaged infusion sets) for 3 h.The peak area of the collected solution was measured and its content was determined by HPLC,and the effect of infusion time on the dissolution of DEHP was investigated as well.RESULTS:The dissolution of DEHP dripped through eight infusion sets were 1 408,9 393,6 576.5,2 412.6,8 194.4,0,8 477.2,and 8 037.4 ?g,respectively.The dissolution increased with the prolonging of infusion time.CONCLUSION:At present,the majority of packaged infusion sets of Paclitaxel injection were made form PVC materials.The safe medication of Paclitaxel can't be ensured for the dissolved DEHP can enter the blood directly,thus its hazardness should be given great attention.
9.Evaluation on in vitro experiment method for Vincristine induced human lymphocyte genetic impairment.
Wei JIANG ; Zhi-Jian CHEN ; Jian-Lin LOU
Chinese Journal of Industrial Hygiene and Occupational Diseases 2007;25(12):759-760
Cells, Cultured
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Comet Assay
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DNA Damage
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drug effects
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Female
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Humans
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Lymphocytes
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drug effects
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Male
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Micronucleus Tests
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Vincristine
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toxicity
10.Applied anatomy of free flap transplant with long superior genicular vessles in reconstruction of lower leg's smashed wound
Jiafu LIN ; Jian LIN ; Bilian WU ; Linglong CHEN
Chinese Journal of Microsurgery 2014;(6):578-581
Objective Anatomical researches of two long superiror genicular vessels,the descending branch of lateral circumflex femoral artery (LCFA) and the descending genicular artery(DGA),were performed to discuss the feasibility of reconstruction in lower leg's destruction injury by free flaps transplant anastomoses with these two long superior genicular vessels.Methods Thirty embalmed lower limb specimens from adult cadavers perfused with red latex were used for this anatomical study.The superior of patella,anterior inferior iliac spine and adductor tubercle were used as observation landmark.Dissection started along the line that from the middle point of Inguinal Ligament to the middle point of superior line of patella,and dividedly turned over to posterior lateral part and posterior medial part.The followings were focused observed:①The external diameter at the beginning of the D-LCFA ; the 0.5 mm external diameter point of this artery,and its length to the beginning and superior of patella.②The external diameter at the beginning of DGA,the distance between the beginning of DGA and adductor tubercle.③Anastomoses relations of final branches of D-LCFA and DGA with other arteries around the knee.Results The external diameter of the beginning of D-LCFA was (2.73 ± 0.35) mm ; the 0.5 mm external diameter point of this artery's length to the beginning and to the superior of patella were (24.56 ± 0.92) cm and (6.09 ± 0.86) cm; both D-LCFA and DGA had sent out many perforator arteries on their ways; the final branch of D-LCFA and DGA had lots of anastomoses relations in perioseal deep fascia and superficial fascia with other genicular arteries.Conclusion Base on the anatomical researches,in theory,the two long superior genicular vessels (D-LCFA and DGA) have enough lengthes and blood supply to regress and anastomosis with free flaps transplant to repair lower leg's smashed wound.