2.Effects of C-peptide on development of chronic diabetic complications and its mechanism
Chinese Journal of Endocrinology and Metabolism 2008;24(4):463-464
Recent studies have suggested that C-peptide in the nanomolar concentration range binds specifically to cell surfaces and plays an important role in the pathological mechanism of chronic complications of diabetes mellitus, via improving the microcirculation, diminishing glomerular hyperfiltration, reducing urinary albumin excretion, protecting the cardiac function and preventing nerve dysfunction. The effects of C-peptide on the development of the chromic diabetic complications and its mechanisms are reviewed.
3.Analysis of clinical features and its influencing factors of depression patients with and without psy-chotic symptoms
Xiuying LI ; Hong CHEN ; Jian XIN
Chinese Journal of Behavioral Medicine and Brain Science 2016;25(8):732-735
Objective To analyze the clinical features and its influencing factors of depression pa?tients with and without psychotic symptoms. Methods According to the presence of psychotic symptoms, 374 patients with major depression were divided into psychotic major depression ( PMD group,79 case) and nonpsychotic major depression ( NMD group,268 case) . All patients completed social demographic question?naire ( including gender,age,marital status,educational level,family history,positive family history of psychi?atric disorder,disease onset age,frequency of attack,times of hospitalization,etc.) and Hamilton's depression scale (HAMD?24). Results Positive family history(PMD group 47/79,NMD group 104/268, P<0.01), psychiatric disorder positive family history(PMD group 19/79,NMD group 26/268, P<0.01) and times of hospitalization(PMD group(2.52±1.29),NMD group(1.39±1.31), P<0.01) in the PMD group were signifi?cantly higher than the NMD group.HAMD total scores(PMD total score(47.85±8.69),NMD total score (43.44±8.51), P<0.01),the factor score of anxiety/somatization(PMD group(11.40±3.28),NMD group (9.19±3.54), P<0.01) and cognitive impairment(PMD group(12.24±3.77),NMD group(9.45±3.68), P<0.01) in the PMD group were significantly higher than the NMD group.Disease onset age(PMD group(30.09 ±5.17),NMD group(35.95±9.06), P<0.01),the course of the disease(PMD group(1.58±0.76),NMD group(3.02±2.87), P<0.01),the factor score of day and night change(PMD group(0.76±0.46),NMD group(1.01±0.51), P<0.01) in PMD group were significantly lower than the NMD. Logistic regression anal?ysis showed the major depression with positive family history of mental disorders( β=3.278) ,attack in early age( β=-2.524),seriously cognitive dysfunction in patients( β=3.836) may indicate the psychotic symp? toms( P<0.05).Conclusion PMD patients more positive family history,psychiatric disorder positive family history,likely to be hospitalization,severe symptoms and attack in early age compared with NMD. With posi?tive family history of mental disorders,attack in early age,seriously cognitive dysfunction in patients with ma?jor depression may indicate the psychotic symptoms.
4.Aorta Imaging with Multi-slice Spiral CT
Hong YAN ; Litong WANG ; Jian CHEN
Chinese Medical Equipment Journal 1989;0(02):-
Objective To investigate the optimum scanning parameters for multi-slice spiral CT aorta imaging so as to emphasize the contrast delay time and the method of image reconstruction.Methods 21 cases of patients were scanned with contrast enhancement by the method of bolus tracking.The contrast medicine was injected through elbow vein.Flow speed was 3.0ml/s,and contrast usage was 1.5 to 2ml/ kg.Scanning was triggered when the density of the enhancement at ROI arose to a prescribed value.After data acquisition and reconstruction,the aorta was displayed.Results The average time for the influx of contrast in aorta was 20 seconds.Data was reformatted with the thickness of 2.5mm and 50% overlapping.VR,CPR,MIP and SSD images were reconstructed.Conclusion With constant tracking of density by Smartprep software,the optimized scanning parameters and the proper image post-processing techniques,aorta can be clearly displayed.[Chinese Medical Equipment Journal,2008,29(2):88-89]
5.The evaluation of risk factors predicting perioperative mortality in patients with colorectal cancer
Jian CHEN ; Hong ZHANG ; Dengguo YAN
Chinese Journal of General Surgery 2014;29(9):708-711
Objective To investigate the potential risk factors for the death of patients with colorectal cancer during perioperative periods.Methods The clinical data of 545 patients with colorectal cancer were analyzed retrospectively.17 factors,which may influence mortality of patients with colorectal cancer during perioperative periods were evaluated.These enumeration data were analyzed with x2 test,then those factors with obvious difference in statistics were further analyzed by multi-factor Logistic regression analysis.The independent risk factors affecting the mortality of patients with colorectal cancer during perioperative periods were obtained from the analysis.Results There were 6 independent risk factors derived that had significant impacts on perioperative death that were postoperative complications,operation method,non-planed reoperation,preoperative electrolyte disturbance,preoperative hypoalbuminemia,and age(P < 0.05).Conclusions Many potential factors could affect perioperative mortality of patients with colorectal cancer undergoing surgical procedure.
7.The clinical research about the relationship between serum levels of 8-hydroxy-deoxyguanosine (8-OHdG) of type 2 diabetes patients and its macrovascular complications
Xiaozhen YE ; Hong DU ; Jihai CHEN ; Huimei CHEN ; Jian WANG
Journal of Chinese Physician 2009;11(2):145-147
Objective To investigate the role of oxidative stress in type 2 diabetes patients with macrovascular complications. Methods Serum levels of 8-hydroxy-deoxygnan osine (8-OHdG) and hemoglobin Alc (HbAlc) in 32 cases of type 2 diabetic patients with macrovascular complications and 46 cases of patients without complications were determined. 8-OHdG was detected by enzyme linked immu-nosorbent assay (ELISA). Results The level of 8-OHdG (2.93±1.37) ng/mL in type 2 diabetic patients with macrovascular complica-tions was higher than those without complications, whose 8-OHdG level was (2.67±1.30)ng/mL, but the difference was not significant(P>0.05). Compared with all kinds of macrovascular complications in patients, the 8-OHdG levels were increased, but the difference were not significant (P>0.05). Compared with patients without complications, the duration and age of the patients with macrovascular compli-cations also increased significantly (P<0.05), but the HbAlc levels were not statistical difference between them (P>0.05). Spearman regression analysis showed that 8-OHdG level was positively correlated with the duration (r=0.33, P<0.05), while the age and HbAlc level had no obvious correlation (P>0.05). Conclusion The role of oxidative stress may not be the important reason in type 2 diabetes with macrovascular complications, but the duration and age of the patients may be closely related with the disease.
8.A study of the mechanisms of recovery from aphasia by speech-activated SPECT brain imaging
Hong WANG ; Zhuo-Ming CHEN ; Jian CHEN ; Hao XU ;
Chinese Journal of Physical Medicine and Rehabilitation 2003;0(09):-
Objective To explore the mechanisms of recovery from aphasia by using speech-activated single photon emission computed tomography(SPECT)brain imaging.Methods The SPECT brain imaging of 7 aphasic patients caused by various brain disorders were performed while they were at rest and performing oral reading,respec- tively,with an one-day interval.A semi-quantitative analysis of regional cerebral blood flow(rCBF)was conducted using region of interesting(ROI).The change of rCBF before and after reading was calculated and compared to ana- lyze the role of both hemispheres in the recovery from aphasia.Results It was found that the activation pattern of brain region was associated with the speech performance of the patients.The activated brain regions were mainly loca- ted at the left hemisphere in 5 patients whose reading capacity was relatively better,and mainly at the right hemi- sphere in the other 2 patients who had poor performance in reading.Conclusion After a focal lesion of the left hemisphere,the recovery of speech function might be mainly attributed to the repair of the damaged left hemisphere language network.When the left-hemispheric centers were permanently impaired,the brain would recruit some right- hemisphere regions for speech processing,but this strategy was less effective than the repair of the original speech-rel- evant network.