Spesis/severe sepsis remains a serious problem in pediatric intensive care unit.The mortality of sepsis/severe sepsis is still very high.The waterfall cascade reaction of cell factors is the main reason leading to the continued deterioration of the condition.Continuous blood purification technology can not only remove inflammatory mediators by adsorption and filtration function,but also improve the immune function,even reduce the mortality rate.But there is a controversial topic on the selection of the appropriate dose.This review not only introduces the effects of high-volume hemofiltration and low-volume hemofiltration from different aspects,but also analyses the influencing factors of different effects.

[Objective]To introduce the clinical experience of Pro.Huo Jiege treating lung cancer in the elderly. [Methods]Through copying prescription with the teacher and carding records, and studing on Chinese literature, sum up Pro.Huo Jiege ’s unique insights for the etiology, pathogenesis, principles and methods, and explains it by one case. [Results] Pro.Huo Jiege thinks that the treatment of elderly lung cancer should base on syndrome differentiation, regulate spleen and stomach and nutrition to other organs at the same time.[Conclusion]The treatment of lung cancer in the elderly patients by Traditional Chinese medicine has achieved some effect in clinical practice and provides guidance in the clinical practice.

laboratorian should understand and evaluate them correctly.

Objective To explore the relationship of test anxiety status between the senior high school students and their parents before college examination entrance.And to study the method and effect of psychological intervention on test anxiety.Methods 315 grade 1 and 295 grade 3 of senior high school students were investigated by using Test Anxiety Scale(TAS),State Anxiety Inventory(S-AI) and Self-Rating Anxiety Scale(SAS);and their Darents were investigated by SAS,S-AI.57 grade 3 of senior high school students and their 102 parents were tested before and after psychological intervention.Results Grade 3 of senior high school students and their parents acquired higher SAS.S-AI scores than grade 1 students and their parents(t=2.422～3.975,P<0.05,P＜O.01).The TAS scores of grade 3 students were higher than grade 1(P＜O.01).The correlative coefficient between students and parents were 0.641,0.759,0.733,0.824 respectively(P<0.01).The TAS,SAS,S-AI scores of grade 3 of senior high school students and the SAS,S-AI scores of their parents were descended significantly [(41.12±10.13)vs(49.24±11.80),(43.05±9.97)vs(49.01±11.29),(53.28±9.87)vs(58.55±10.20),(52.47±9.91)vs(59.18±11.75),t=2.861～4.456,P＜O.01].Conclusion There was higher anxiety level in grade 3 of senior high school students and their parents.The correlations was strong between themPsychological intervention on students together with their parents are effective to relax test anxiety level of senior high school students before college examination entrance.

The new,rapid,accurate and convenient tests for tuberculosis diagnosis and drug resistance are urgently needed for effective tuberculosis control.In this review,two novel,inexpensive diagnosis methods of active TB were introduced.They can detect tuberculosis disease and drug resistances directly form sputum specimens and might have greater applicability in developing countries.Several concerns about the research and development of innovative diagnosis technology in our country also are described.

Objective:To evaluate the bio-mechanics of the cracked molars. Methods: A three dimensional finite element(3D-FEM) model of an upper first molar was constructed by Ansys 8.0 software. The model's cuspal inclination was shaped according to the mean value of the cuspal inclination in the cracked maxillary first molars and the intact ones respectively. The influence of cuspal inclination on the stress distribution was evaluated under different loads:Load of 600 N vertically applied to the occlusal surface of the model, or load of 200 N applied from three directions (vertically, at a 45?angle, horizontally). Results:For the model with the cuspal inclination of the cracked maxillary first molars, its maximum tensile stress, compressive stress and Von Mises stress were higher than those of the control models. The tensile stress and Von Mises stress increased with the increase of force direction and became to the highest under horizontal loads. The tensile stress was mainly distributed at the mediolingual cusp, centre groove and the palatal side of the cervical region. Conclusions: Under equivalent loads, the molar with bigger cuspal inclination suffers more unfavorable stress, which will magnify the occurrence of cracked tooth syndrome (CTS), and horizontal bite force may be a critical factor.

BACKGROUND:Preparation of titanium/hydroxyapatite composite by conventional methods has the deficiency of simple structure, low degree of automation and difficulty in porosity and pore size control, which limits the diverse process and manufacture. OBJECTIVE:To evaluate the feasibility of three-dimensional printing technology for the preparation of titanium/hydroxyapatite composite and titanium/hydroxyapatite functional y graded material molding. METHODS:A CAD model of titanium/hydroxyapatite composite was designed to be the cylinder (diameter 25 mm, height 20 mm), while the titanium/hydroxyapatite functional y graded implant designed as a CAD model of the cylinder with 25 mm in diameter asnd 10 mm in height with two layers, the upper layer with titanium powder and the lower layer with titanium/hydroxyapatite powder. The composite and functional y graded implant were processed by the three-dimensional printing and sintered. The sintered titanium/hydroxyapatite composite and titanium/hydroxyapatite functional y graded implant were observed for their microstructures, and the X-ray diffraction analysis and compressive strength testing were performed. RESULTS AND CONCLUSION:The sintered titanium/hydroxyapatite composite and titanium/hydroxyapatite functional y graded implant had uniform contraction and no obvious distortion. The sintered titanium/hydroxyapatite composite had the aperture size from 50 to 150μm. There occurred a chemical reaction between titanium and hydroxyapatite during the sintering process, obtaining the new creations of Ca3(PO4)2, CaTiO3, TiO2 and CaO. Its compressive strength was (184.3±27.1) MPa. The microstructure of titanium/hydroxyapatite functional y graded implant had graded structures with a visible line between the two layers. The results of the microstructure and mechanical properties of titanium/hydroxyapatite composite and titanium/hydroxyapatite functional y graded implant can meet the requirements of medical biological implant materials.

Resting energy expenditure is the main indicator to assess energy consu mpit on of ap tine ts. The ne eryg expenditure of critically ill children can be influenced by many factors.Different ts atse of diseases are followed by different values of resting energy expenditure.Right now,indirect calorimetry is the “golden standard” of measurement of energy metabolism.Indirect calorimetry can be used to accurately grasp energy expenditure of patients.And it is beneficial to optimization of nutrition support,also for individualized nutri-tion therapy.

Objective To investigate the changes of VCAM-1 and ICAM-1 levels in tumor and peripheral blood in pancreatic cancer patients. Methods 28 cases with pancreatic cancer were selected from August 2013 to Octorber 2014 as experiment group,28 cases with acute pancreatitis who needed removal of pancreas as control group,28 healthy people as normal group.ICAM-1 and VCAM-1 in tissue were compared and sVCAM-1 and sICAM-1 in serum were compared.Results ICAM-1 and VCAM-1 in tissue of experiment group were significantly higher than normal group(P<0.05), sICAM-1,sVCAM-1 in serum of experiment group were higher than control group and normal group(P<0.05),there were no correlation between CEA and sICAM-1,sVCAM-1 in serum of experiment group(r=0.116,P>0.05;r=0.093,P>0.05),there were positive correlation between CA19-9 and sICAM-1,sVCAM-1 in serum of experiment group(r=0.573,P<0.01;r=0.435,P<0.05).Compared with pre-operation, the serum concentrations of sVCAM-1 and sICAM-1 were lower(P<0.05).Conclusion ICAM-1 and VCAM-1in pancreatic cancer patients are significantly higher than that in acute pancreatitis patients and healthy people, the correlation of ICAM-1 and VCAM-1 expression in pancreatic cancer, early diagnosis and treatment of pancreatic cancer has important significance.

Objective To investigate regional cerebral blood flow (rCBF) in hypodense areas of the brain after severe traumatic brain injury (sTBI). Methods CT perfusion (CTP) was performed in 42 patients with sTBI during the period of 2011 to 2013. According to the findings of CT scans , hypodense lesions were divided into contusion- or infarction-associated regions. Regional cerebral blood volume (rCBV) of < 15 mL/(100 g·min) was used as the threshold of severe ischemia; rCBF, rCBV, and regional mean transit time (MTT) for the hypodense lesions were analyzed, and the incidence of severe ischemia was compared between the two groups. Results A total of 62 hypodense lesions were identified in the patients. 45 of the 62 hypodense lesions were associated with contusion, and 17 of the lesions were associated with infarction. The mean CT density was significantly lower in the hypodense regions than in the contralateral mirror regions (P<0.05), and there was no significant difference in the mean CT density between the two types of lesions (P > 0.05). Cerebral perfusion was significantly lower in the contusion-associated hypodense regions than in the contralateral mirror regions (P<0.05). In the contrast, cerebral perfusion in the hypodense areas associated with infarction did not significantly differ from that in the contralateral mirror regions (P>0.05). A reduction in rCBF<15 mL/(100 g·min) was found in 25 of the hypodense regions associated with contusion, but only one of those associated with infarction. Conclusions Cerebral perfusion in contusion-associated hypodense areas decreases significantly , but not in infarction-associated hypodense areas. Correct identification of cerebral perfusion in the hypodense areas is helpful for developing therapeutic strategies.