For stage Ⅱ colon cancer patients after surgery,the benefit of adjuvant chemotherapy remains controversial.Several studies indicate that the patients with high-risk stage Ⅱ colon cancer can benefit from adjuvant chemotherapy after surgery.According to the clinical and pathological features,the stage Ⅱcolon cancer patients including T4 lesion,perforation,peritumoral lymphovascular invasion can benefit from the adjuvant chemotherapy of oxaliplatin.In the horizontal of molecular and genetic levels,the stage Ⅱ colon cancer patients can express high microsatellite instability (MSI-H) and cannot benefit from the chemotherapy of Fluorouracil.The guiding functions of 18q loss of heterozygosity (18q LOH),Cx43 and gene expression profiling in adjuvant chemotherapy are still unclear,and need further study.

Crohn Disease ; epidemiology ; surgery ; Humans

China ; epidemiology ; Humans ; Mesentery ; surgery ; Rectal Neoplasms ; epidemiology ; surgery

There is a significant gap between China and the optimal international level in terms of the treatment outcomes of colorectal cancer. In recent years, progresses have been made while limitations still exist in the management of colorectal cancer. Advances are seen including use of multi-disciplinary therapy, neoadjuvant chemoradiation, laparoscopic surgery and management of liver metastasis. Individualized therapy is also applied in colorectal cancer. However, randomized controlled trials based on Chinese population are still lacking. Radiation therapy is inadequate and standardization of surgical technique is to be improved. Although standardization of management of colorectal cancer has gained attention from the government, there is a long way to go. The establishment of subspecialty training and practice has not been satisfactory. National efforts are needed to improve the treatment outcomes of colorectal cancer in China.
China ; Colorectal Neoplasms ; therapy ; Humans ; Laparoscopy ; Liver Neoplasms ; Neoadjuvant Therapy ; Treatment Outcome

To augment the levels of diagnosis and treatment for colorectal cancer and make them standardization in China, the Ministry of Health of the People's Republic of China released Chinese Standard for The Management of Colorectal Cancer (2010) in November 4, 2010. This standard incorporates the most recent progresses in colorectal cancer, and it provides standard guidelines with respect to diagnosis, pathologic examination, surgery, adjuvant therapy in the management of colorectal cancer in China.
China ; Colorectal Neoplasms ; diagnosis ; therapy ; Humans ; Practice Guidelines as Topic

Humans ; Neoplasm Recurrence, Local ; prevention & control ; Rectal Neoplasms ; pathology

Ascorbic Acid ; adverse effects ; immunology ; Child, Preschool ; Drug Hypersensitivity ; etiology ; Family ; Female ; Humans ; Male

Colorectal Neoplasms ; therapy ; Humans ; Neoadjuvant Therapy

Clinical Trials as Topic ; standards ; Humans ; Quality Control

Aluminum ; urine ; Humans ; Metallurgy ; Occupational Exposure ; analysis ; Reproducibility of Results ; Spectrophotometry ; methods