Glucocorticoid(GC) /glucocorticoid receptor(GR) inhibits cell proliferation and protects cells from apoptosis induced by serum deprivation,hypoxia,irradiation or chemotherapy drugs in many cell types,thereby GC/GR can maintain cell number homeostasis,which is an important aspect of homeostasis regulation of GC/GR in higher organisms.This article reviews antiproliferative and antiapoptotic effects of GC/GR on cell and their molecular mechanism,mainly focusing on the molecular events and target genes downstream of GC/GR.

Objective To understand the current status of intestinal helminth infections in Dafeng City. Methods The resi?dents in 5 villages of Dafeng City were investigated and their stool samples were detected for the eggs of helminth with Kato?Katz technique and Enterobius vermicularis was detected by the cellophane anal swab method. Results The total infection rates of intestinal helminth were 5.77% 5.51% 4.60% 4.18% 3.41% and 1.38% from 2005 to 2010 respectively. The trend of total infection rates declined year by year. The infection rates in the 20?30 age?group and 60?80 age?group were higher than those in other age?groups. The infection rates of the male and female were 5.63 359/6 375 and 2.42 144/5 949 re?spectively and there was a significant difference χ2=74.81 P=0.00 . The infection rate 11.70% in the northern areas of Dafeng City was higher than that in other places and the trend of the infection rates decreased from the eastern and northern to the western and southern. The infection rate of E. vermicularis was 1.75%in children in 2010. Conclusions The infection rate of intestinal helminth is low but E. vermicularis infection is relatively general in the children in Dafeng City. Therefore the pre?vention and treatment still need to be strengthened.

Humans ; Multiple Myeloma ; Neoplasm Recurrence, Local

Objective To get a better understanding of the characteristic MRI appearances of cerebral MS lesions.Methods 61 patients with clinically diagnosed multiple sclerosis were examined with SE sequences,using 0.5T super-conducting scanner.The MRI features of MS were analyzed.Results All of the patients in 61 cases were found MS lesions in MRI.The lesions in cerebral,brainstem,and cerebellum were clearly visualized,but in optic nerves were not so good.The MS foci appeared low or middle signal intensity in T 1WI and high signal intensity in T 2WI.It was playing an important role in the diagnosis of the MS that the paraventricular lesions were perpendicular to the lateral ventricles and there were MRI abnormal signals in corpus callosum with shrinking. Conclusion MRI can show the characteristic appearances of MS lesions,demonstrate many more lesions that not visible on CT scan,provide informations about the number,size,location and extent of the lesions therefore MRI is the first method of choice in the diagnosis of MS.

Posterior scleritis,an inflammatory disease of the posterior sclera,is most commonly seen in middle-aged women and often associated with systemic immunological diseases.It presents with a variety of nonspecific signs and symptoms,and its clinical feature may be confused with ocular tumors,orbital inflammation,and retinochoroidopathy.Therefore,some auxiliary examinations are necessary for the diagnosis of posterior scleritis.With early proper diagnosis and treatment,severe complications of posterior scleritis can be avoided or lessened.In the paper,some advancement in the study of etiology,incidence,signs,symptoms,auxiliary examination,differential diagnosis and treatment of posterior scleritis were reviewed.

Brain injury is one of the most common diseases in PICU.Bedside electroencephalogram monitoring is the most commonly used to evaluate cerebral function.Bedside electroencephalogram monitoring includes continuous electroencephalogram,video electroencephalogram and cerebral function trends,such as amplitude integrated electroencephalogram,envelope and band power.

Primary intrahepatic stone is a common disease in China. It is difficult to treat this benign biliary tract disease because it has many complications and the surgery is difficult. Understanding the cause of this disease has important implications in prevention and treatment. This article reviewed the cause of primary intrahepatic stone from four aspects: imbalance of bile components, infection, bile protein, and macromolecular and metabolism of the cells.

Nosocomial infection of Pseudomonas aeruginosa is a dilemma in clinic,especially at ICU with high rate of antibiotic resistance,and lead to ventilator associated pneumonia,bloodstream infections, etc.There are difficulties in the treatment,lengthening of ICU stay,high mortality and increased treatment costs.Positive prevention,early diagnosis,reasonable antiboitics are the key to the benign prognosis of Pseud-omonas aeruginosa.

Peroxisome proliferators-activated receptor-gamma(PPAR?),one of members of the nuclear hormone receptor superfamily of ligand-activated transcription factors,may affect the ocurrence and development of atherosclerosis(AS) through effective modulate lipocyte differentiation,improve glucose and lipoprotein decompensation and control inflammation reaction and so on.This review will focus on the recently development that relation on PPAR? and AS.

Purpose:To investigate whether transforming growth factor ?1 (TGF ?1) pathway is involved in the mechanism of dexamethasone (Dex) mediated proliferation inhibition in ovarian cancer cell line HO 8910.Methods:To analyse cell proliferation and cell cycle distribution by cell counts and flow cytometric analysis, respectively ; to determine the expression levels of TGF ?1 and its two receptors, T?R Ⅰ and T?R Ⅱ , by quantative RT PCR, ELISA and(or) immunocytochemistry methods.Results:Dex induced a G 0 /G 1 cell cycle arrest in HO 8910 cells, and it up regulated T?R Ⅱ expression in a concentration dependent manner.The level of T?R Ⅱ mRNA was the highest after treatment with Dex for 8 hours, with 1.4 fold more than that of control at concentration of 10 -7 mol/L ( P